6GFX

pVHL:EloB:EloC in complex with modified HIF-1a CODD peptide containing (3R,4S)-3-fluoro-4-hydroxyproline (ligand 13a)

Summary for 6GFX

Entry DOI	10.2210/pdb6gfx/pdb
Descriptor	Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (5 entities in total)
Functional Keywords	protein-peptide complex, ubiquitin ligase, hypoxia inducible factor, ligase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	43543.63
Authors	Castro, G.V.,Testa, A.,Ciulli, A. (deposition date: 2018-05-02, release date: 2018-07-11, Last modification date: 2018-08-01)
Primary citation	Testa, A.,Lucas, X.,Castro, G.V.,Chan, K.H.,Wright, J.E.,Runcie, A.C.,Gadd, M.S.,Harrison, W.T.A.,Ko, E.J.,Fletcher, D.,Ciulli, A. 3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation. J. Am. Chem. Soc., 140:9299-9313, 2018 Cited by PubMed: 29949369 DOI: 10.1021/jacs.8b05807 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.83 Å)

Structure validation