6BVB

Crystal structure of HIF-2alpha-pVHL-elongin B-elongin C

Summary for 6BVB

Entry DOI	10.2210/pdb6bvb/pdb
Descriptor	von Hippel-Lindau disease tumor suppressor, Elongin-B, Elongin-C, ... (5 entities in total)
Functional Keywords	e3 ubiquitin ligase, gene regulation
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	44890.91
Authors	Tarade, D.,Ohh, M.,Lee, J.E. (deposition date: 2017-12-12, release date: 2018-08-01, Last modification date: 2023-10-04)
Primary citation	Tarade, D.,Robinson, C.M.,Lee, J.E.,Ohh, M. HIF-2 alpha-pVHL complex reveals broad genotype-phenotype correlations in HIF-2 alpha-driven disease. Nat Commun, 9:3359-3359, 2018 Cited by PubMed: 30135421 DOI: 10.1038/s41467-018-05554-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.002 Å)

Structure validation