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1IRL
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1irl
THE SOLUTION STRUCTURE OF THE F42A MUTANT OF HUMAN INTERLEUKIN 2
Descriptor:INTERLEUKIN-2
Authors:Mott, H.R., Baines, B.S., Hall, R.M., Cooke, R.M., Driscoll, P.C., Weir, M.P., Campbell, I.D.
Deposit date:1995-08-25
Release date:1995-12-07
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:The solution structure of the F42A mutant of human interleukin 2.
J.Mol.Biol., 247, 1995
1M47
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1m47
CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN-2
Descriptor:interleukin-2
Authors:Arkin, M.A., Randal, M., DeLano, W.L., Hyde, J., Luong, T.N., Oslob, J.D., Raphael, D.R., Taylor, L., Wang, J., Wells, J.A., McDowell, R.S., Wells, J.A., Braisted, A.C.
Deposit date:2002-07-02
Release date:2002-07-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Binding of small molecules to an adaptive protein-protein interface
Proc.Natl.Acad.Sci.USA, 100, 2003
1M48
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1m48
CRYSTAL STRUCTURE OF HUMAN IL-2 COMPLEXED WITH (R)-N-[2-[1-(AMINOIMINOMETHYL)-3-PIPERIDINYL]-1-OXOETHYL]-4-(PHENYLETHYNYL)-L-PHENYLALANINE METHYL ESTER
Descriptor:interleukin-2
Authors:Arkin, M.A., Randal, M., DeLano, W.L., Hyde, J., Luong, T.N., Oslob, J.D., Raphael, D.R., Taylor, L., Wang, J., McDowell, R.S., Wells, J.A., Braisted, A.C.
Deposit date:2002-07-02
Release date:2002-07-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Binding of small molecules to an adaptive protein-protein interface
Proc.Natl.Acad.Sci.USA, 100, 2003
1M49
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1m49
CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN-2 COMPLEXED WITH SP-1985
Descriptor:interleukin-2
Authors:Arkin, M.A., Randal, M., DeLano, W.L., Hyde, J., Luong, T.N., Oslob, J.D., Raphael, D.R., Taylor, L., Wang, J., McDowell, R.S., Wells, J.A., Braisted, A.C.
Deposit date:2002-07-02
Release date:2002-07-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Binding of small molecules to an adaptive protein-protein interface
Proc.Natl.Acad.Sci.USA, 100, 2003
1M4A
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1m4a
CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN-2 Y31C COVALENTLY MODIFIED AT C31 WITH (1H-INDOL-3-YL)-(2-MERCAPTO-ETHOXYIMINO)-ACETIC ACID
Descriptor:interleukin-2
Authors:Arkin, M.A., Randal, M., DeLano, W.L., Hyde, J., Luong, T.N., Oslob, J.D., Raphael, D.R., Taylor, L., Wang, J., McDowell, R.S., Wells, J.A., Braisted, A.C.
Deposit date:2002-07-02
Release date:2002-07-31
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Binding of small molecules to an adaptive protein-protein interface
Proc.Natl.Acad.Sci.USA, 100, 2003
1M4B
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1m4b
CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN-2 K43C COVALENTLY MODIFIED AT C43 WITH 2-[2-(2-CYCLOHEXYL-2-GUANIDINO-ACETYLAMINO)-ACETYLAMINO]-N-(3-MERCAPTO-PROPYL)-PROPIONAMIDE
Descriptor:interleukin-2
Authors:Arkin, M.A., Randal, M., DeLano, W.L., Hyde, J., Luong, T.N., Oslob, J.D., Raphael, D.R., Taylor, L., Wang, J., McDowell, R.S., Wells, J.A., Braisted, A.C.
Deposit date:2002-07-02
Release date:2002-07-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Binding of small molecules to an adaptive protein-protein interface
Proc.Natl.Acad.Sci.USA, 100, 2003
1M4C
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1m4c
CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN-2
Descriptor:interleukin-2
Authors:Arkin, M.A., Randal, M., DeLano, W.L., Hyde, J., Luong, T.N., Oslob, J.D., Raphael, D.R., Taylor, L., Wang, J., McDowell, R.S., Wells, J.A., Braisted, A.C.
Deposit date:2002-07-02
Release date:2002-07-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Binding of small molecules to an adaptive protein-protein interface
Proc.Natl.Acad.Sci.USA, 100, 2003
1NBP
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1nbp
CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN-2 Y31C COVALENTLY MODIFIED AT C31 WITH 3-MERCAPTO-1-(1,3,4,9-TETRAHYDRO-B-CARBOLIN-2-YL)-PROPAN-1-ONE
Descriptor:Interleukin-2
Authors:Hyde, J., Braisted, A.C., Randal, M., Arkin, M.R.
Deposit date:2002-12-03
Release date:2002-12-18
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery and characterization of cooperative ligand binding in the adaptive region of interleukin-2
Biochemistry, 42, 2003
1PW6
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1pw6
LOW MICROMOLAR SMALL MOLECULE INHIBITOR OF IL-2
Descriptor:Interleukin-2
Authors:Thanos, C.D., Randal, M., Wells, J.A.
Deposit date:2003-06-30
Release date:2004-01-13
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Potent small-molecule binding to a dynamic hot spot on IL-2.
J.Am.Chem.Soc., 125, 2003
1PY2
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1py2
STRUCTURE OF A 60 NM SMALL MOLECULE BOUND TO A HOT SPOT ON IL-2
Descriptor:Interleukin-2
Authors:Thanos, C.D., Randal, M., Wells, J.A.
Deposit date:2003-07-07
Release date:2004-01-13
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Potent small-molecule binding to a dynamic hot spot on IL-2.
J.Am.Chem.Soc., 125, 2003
1QVN
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1qvn
STRUCTURE OF SP4160 BOUND TO IL-2 V69A
Descriptor:Interleukin-2
Authors:Thanos, C.D., Delano, W.L., Wells, J.A.
Deposit date:2003-08-28
Release date:2005-04-05
Modification date:2013-01-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Hot-spot mimicry of a cytokine receptor by a small molecule.
Proc.Natl.Acad.Sci.USA, 103, 2006
3INK
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3ink
UNRAVELING THE STRUCTURE OF INTERLEUKIN-2: REPLY
Descriptor:INTERLEUKIN 2 MUTANT WITH CYS 125 REPLACED BY ALA (C125A)
Authors:Mckay, D.B., Brandhuber, B.J.
Deposit date:1992-12-09
Release date:1993-10-31
Modification date:2013-09-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Response.
Science, 257, 1992
3QB1
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3qb1
INTERLEUKIN-2 MUTANT D10
Descriptor:Interleukin-2
Authors:Levin, A.M., Bates, D.L., Ring, A.M., Lin, J.T., Su, L., Krieg, C., Bowman, G.R., Novick, P., Pande, V.S., Khort, H.E., Boyman, O., Fathman, C.G., Garcia, K.C.
Deposit date:2011-01-12
Release date:2012-04-11
Modification date:2014-10-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'
Nature, 484, 2012
4NEJ
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4nej
SMALL MOLECULAR FRAGMENT BOUND TO CRYSTAL CONTACT INTERFACE OF INTERLEUKIN-2
Descriptor:Interleukin-2
Authors:Brenke, R., Jehle, S., Vajda, S., Allen, K.N., Kozakov, D.
Deposit date:2013-10-29
Release date:2014-11-19
Method:X-RAY DIFFRACTION (1.919 Å)
Cite:Small molecular fragments bound to binding energy hot-spot in crystal contact interface of Interleukin-2
To be Published
4NEM
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4nem
SMALL MOLECULAR FRAGMENT BOUND TO CRYSTAL CONTACT INTERFACE OF INTERLEUKIN-2
Descriptor:Interleukin-2
Authors:Jehle, S., Brenke, R., Vajda, S., Allen, K.N., Kozakov, D.
Deposit date:2013-10-29
Release date:2014-11-19
Method:X-RAY DIFFRACTION (1.934 Å)
Cite:Small molecular fragments bound to binding energy hot-spot in crystal contact interface of Interleukin-2
To be Published
1Z92
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1z92
STRUCTURE OF INTERLEUKIN-2 WITH ITS ALPHA RECEPTOR
Descriptor:Interleukin-2, Interleukin-2 receptor alpha chain
Authors:Rickert, M., Wang, X.Q., Goriatcheva, N., Boulanger, M.J., Garcia, K.C.
Deposit date:2005-03-31
Release date:2005-06-07
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The structure of interleukin-2 complexed with its alpha receptor.
Science, 308, 2005
2B5I
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2b5i
CYTOKINE RECEPTOR COMPLEX
Descriptor:Interleukin-2, Interleukin-2 receptor beta chain, Cytokine receptor common gamma chain, Interleukin-2 receptor alpha chain
Authors:Wang, X., Rickert, M., Garcia, K.C.
Deposit date:2005-09-28
Release date:2005-11-29
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors.
Science, 310, 2005
3QAZ
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3qaz
IL-2 MUTANT D10 TERNARY COMPLEX
Descriptor:Interleukin-2, Interleukin-2 receptor subunit beta, Cytokine receptor common subunit gamma
Authors:Levin, A.M., Bates, D.L., Ring, A.M., Lin, J.T., Su, L., Krieg, C., Bowman, G.R., Novick, P., Pande, V.S., Khort, H.E., Boyman, O., Gathman, C.G., Garcia, K.C.
Deposit date:2011-01-12
Release date:2012-04-11
Modification date:2014-10-15
Method:X-RAY DIFFRACTION (3.802 Å)
Cite:Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'
Nature, 484, 2012
2ERJ
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2erj
CRYSTAL STRUCTURE OF THE HETEROTRIMERIC INTERLEUKIN-2 RECEPTOR IN COMPLEX WITH INTERLEUKIN-2
Descriptor:Interleukin-2 receptor alpha chain, Interleukin-2 receptor beta chain, Cytokine receptor common gamma chain
Authors:Debler, E.W., Stauber, D.J., Wilson, I.A.
Deposit date:2005-10-25
Release date:2006-02-21
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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entries available on 2014-12-17
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