1PW6
Low Micromolar Small Molecule Inhibitor of IL-2
Summary for 1PW6
Entry DOI | 10.2210/pdb1pw6/pdb |
Descriptor | Interleukin-2, SULFATE ION, 2-CYCLOHEXYL-N-(2-{4-[5-(2,3-DICHLORO-PHENYL)-2H-PYRAZOL-3-YL]-PIPERIDIN-1-YL}-2-OXO-ETHYL)-2-GUANIDINO-ACETAMIDE (3 entities in total) |
Functional Keywords | il-2 interleukin 2 small molecule inhibitor, immune system |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P60568 |
Total number of polymer chains | 2 |
Total formula weight | 32036.98 |
Authors | Thanos, C.D.,Randal, M.,Wells, J.A. (deposition date: 2003-06-30, release date: 2004-01-13, Last modification date: 2018-02-14) |
Primary citation | Thanos, C.D.,Randal, M.,Wells, J.A. Potent small-molecule binding to a dynamic hot spot on IL-2. J.Am.Chem.Soc., 125:15280-15281, 2003 Cited by PubMed: 14664558DOI: 10.1021/ja0382617 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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