3QB1

Interleukin-2 mutant D10

Summary for 3QB1

• Entry DOI: 10.2210/pdb3qb1/pdb
• Related: 1M47 3INK 3QAZ
• Descriptor: Interleukin-2 (1 entity in total)
• Functional Keywords: high affinity il-2 cytokine, cytokine
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P60568
• Total number of polymer chains: 8
• Total formula weight: 125817.22

Authors

Levin, A.M.,Bates, D.L.,Ring, A.M.,Lin, J.T.,Su, L.,Krieg, C.,Bowman, G.R.,Novick, P.,Pande, V.S.,Khort, H.E.,Boyman, O.,Fathman, C.G.,Garcia, K.C. (deposition date: 2011-01-12, release date: 2012-04-11, Last modification date: 2023-09-13)

• Primary citation: Levin, A.M.,Bates, D.L.,Ring, A.M.,Krieg, C.,Lin, J.T.,Su, L.,Moraga, I.,Raeber, M.E.,Bowman, G.R.,Novick, P.,Pande, V.S.,Fathman, C.G.,Boyman, O.,Garcia, K.C.; Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'; Nature, 484:529-533, 2012; PubMed: 22446627; DOI: 10.1038/nature10975

Experimental method

X-RAY DIFFRACTION (3.1 Å)