5LQB

Complex structure of human IL2 mutant, Proleukin, with Fab fragment of NARA1 antibody

Summary for 5LQB

• Entry DOI: 10.2210/pdb5lqb/pdb
• Descriptor: Interleukin-2, anti-hIL2 FAB fragment heavy chain, anti-hIL2 FAB fragment light chain, ... (4 entities in total)
• Functional Keywords: il2, proleukin, nara1, anti-il2, cytokine
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted: P60568
• Total number of polymer chains: 3
• Total formula weight: 63049.49

Authors

Zou, C.,Wirth, E. (deposition date: 2016-08-16, release date: 2016-12-14, Last modification date: 2024-01-10)

• Primary citation: Arenas-Ramirez, N.,Zou, C.,Popp, S.,Zingg, D.,Brannetti, B.,Wirth, E.,Calzascia, T.,Kovarik, J.,Sommer, L.,Zenke, G.,Woytschak, J.,Regnier, C.H.,Katopodis, A.,Boyman, O.; Improved cancer immunotherapy by a CD25-mimobody conferring selectivity to human interleukin-2.; Sci Transl Med, 8:367ra166-367ra166, 2016; PubMed: 27903862; DOI: 10.1126/scitranslmed.aag3187

Experimental method

X-RAY DIFFRACTION (1.95 Å)