1BJ1
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VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH A NEUTRALIZING ANTIBODY
Descriptor:FAB FRAGMENT, VASCULAR ENDOTHELIAL GROWTH FACTOR
Authors:Muller, Y.A., Christinger, H.W., De Vos, A.M.
Deposit date:1998-06-30
Release date:1999-01-13
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface.
Structure, 6, 1998
1CZ8
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VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY
Descriptor:VASCULAR ENDOTHELIAL GROWTH FACTOR/LIGHT CHAIN OF NEUTRALIZING ANTIBODY/HEAVY CHAIN OF NEUTRALIZING ANTIBODY COMPLEX
Authors:Chen, Y., Wiesmann, C., Fuh, G., Li, B., Christinger, H.W., McKay, P., de Vos, A.M., Lowman, H.B.
Deposit date:1999-09-01
Release date:2000-03-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen.
J.Mol.Biol., 293, 1999
1FLT
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VEGF IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR
Descriptor:VASCULAR ENDOTHELIAL GROWTH FACTOR, FMS-LIKE TYROSINE KINASE 1
Authors:Wiesmann, C., De Vos, A.M.
Deposit date:1997-11-20
Release date:1999-01-13
Modification date:2012-05-02
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor.
Cell(Cambridge,Mass.), 91, 1997
1FZV
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THE CRYSTAL STRUCTURE OF HUMAN PLACENTA GROWTH FACTOR-1 (PLGF-1), AN ANGIOGENIC PROTEIN AT 2.0A RESOLUTION
Descriptor:PLACENTA GROWTH FACTOR
Authors:Iyer, S., Leonidas, D.D., Swaminathan, G.J., Maglione, D., Battisti, M., Tucci, M., Persico, M.G., Acharya, K.R.
Deposit date:2000-10-04
Release date:2001-05-09
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution.
J.Biol.Chem., 276, 2001
1KAT
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SOLUTION STRUCTURE OF A PHAGE-DERIVED PEPTIDE ANTAGONIST IN COMPLEX WITH VASCULAR ENDOTHELIAL GROWTH FACTOR
Descriptor:Vascular Endothelial Growth Factor/Phage-Derived Peptide Antagonist
Authors:Pan, B., Li, B., Russell, S.J., Tom, J.Y.K., Cochran, A.G., Fairbrother, W.J.
Deposit date:2001-11-02
Release date:2002-11-02
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution Structure of a Phage-derived Peptide Antagonist in Complex with Vascular Endothelial Growth Factor
J.Mol.Biol., 316, 2002
1MJV
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DISULFIDE DEFICIENT MUTANT OF VASCULAR ENDOTHELIAL GROWTH FACTOR A (C51A AND C60A)
Descriptor:Vascular Endothelial Growth Factor A
Authors:Muller, Y.A., Heiring, C., Misselwitz, R., Welfle, K., Welfle, H.
Deposit date:2002-08-28
Release date:2002-12-11
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor
J.Biol.Chem., 277, 2002
1MKG
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DISULFIDE DEFICIENT MUTANT OF VASCULAR ENDOTHELIAL GROWTH FACTOR A (C57A AND C102A)
Descriptor:Vascular Endothelial Growth Factor A
Authors:Muller, Y.A., Heiring, C., Misselwitz, R., Welfle, K., Welfle, H.
Deposit date:2002-08-29
Release date:2002-12-11
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor
J.Biol.Chem., 277, 2002
1MKK
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DISULFIDE DEFICIENT MUTANT OF VASCULAR ENDOTHELIAL GROWTH FACTOR A (C61A AND C104A)
Descriptor:Vascular Endothelial Growth Factor A
Authors:Muller, Y.A., Heiring, C., Misselwitz, R., Welfle, K., Welfle, H.
Deposit date:2002-08-29
Release date:2002-12-11
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor
J.Biol.Chem., 277, 2002
1QTY
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VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR
Descriptor:VASCULAR ENDOTHELIAL GROWTH FACTOR
Authors:Wiesmann, C., de Vos, A.M.
Deposit date:1999-06-29
Release date:2000-01-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states.
J.Mol.Biol., 293, 1999
1RV6
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CRYSTAL STRUCTURE OF PLGF IN COMPLEX WITH DOMAIN 2 OF VEGFR1
Descriptor:placenta growth factor (PlGF), FLT1 protein
Authors:Christinger, H.W., Fuh, G., de Vos, A.M., Wiesmann, C.
Deposit date:2003-12-12
Release date:2004-01-20
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1.
J.Biol.Chem., 279, 2004
1TZH
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CRYSTAL STRUCTURE OF THE FAB YADS1 COMPLEXED WITH H-VEGF
Descriptor:Vascular endothelial growth factor A, Fab YADS1 Light Chain, Fab YADS1 Heavy Chain
Authors:Fellouse, F.A., Wiesmann, C., Sidhu, S.S.
Deposit date:2004-07-09
Release date:2004-08-31
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Synthetic antibodies from a four-amino-acid code: A dominant role for tyrosine in antigen recognition
Proc.Natl.Acad.Sci.USA, 101, 2004
1TZI
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CRYSTAL STRUCTURE OF THE FAB YADS2 COMPLEXED WITH H-VEGF
Descriptor:Fab YADS2 Light Chain, Fab YADS2 Heavy Chain, Vascular endothelial growth factor A
Authors:Fellouse, F.A., Wiesmann, C., Sidhu, S.S.
Deposit date:2004-07-10
Release date:2004-08-31
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Synthetic antibodies from a four-amino-acid code: A dominant role for tyrosine in antigen recognition
Proc.Natl.Acad.Sci.USA, 101, 2004
1VPF
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STRUCTURE OF HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR
Descriptor:VASCULAR ENDOTHELIAL GROWTH FACTOR
Authors:Muller, Y.A., De Vos, A.M.
Deposit date:1997-04-08
Release date:1998-04-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site.
Proc.Natl.Acad.Sci.USA, 94, 1997
1VPP
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COMPLEX BETWEEN VEGF AND A RECEPTOR BLOCKING PEPTIDE
Descriptor:PROTEIN (VASCULAR ENDOTHELIAL GROWTH FACTOR)
Authors:Wiesmann, C., Christinger, H.W., Cochran, A.G., Cunningham, B.C., Fairbrother, W.J., Keenan, C.J., Meng, G., de Vos, A.M.
Deposit date:1998-10-09
Release date:1999-02-23
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the complex between VEGF and a receptor-blocking peptide.
Biochemistry, 37, 1998
2C7W
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CRYSTAL STRUCTURE OF HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR-B: IDENTIFICATION OF AMINO ACIDS IMPORTANT FOR ANGIOGENINC ACTIVITY
Descriptor:VASCULAR ENDOTHELIAL GROWTH FACTOR B PRECURSOR
Authors:Iyer, S., Scotney, P.D., Nash, A.D., Acharya, K.R.
Deposit date:2005-11-29
Release date:2007-01-30
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Crystal Structure of Human Vascular Endothelial Growth Factor-B: Identification of Amino Acids Important for Receptor Binding
J.Mol.Biol., 359, 2006
2FJG
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STRUCTURE OF THE G6 FAB, A PHAGE DERIVED FAB FRAGMENT, IN COMPLEX WITH VEGF
Descriptor:Vascular endothelial growth factor A, Fab light chain, Fab heavy chain
Authors:Wiesmann, C.
Deposit date:2006-01-02
Release date:2006-02-07
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.
J.Biol.Chem., 281, 2006
2FJH
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STRUCTURE OF THE B20-4 FAB, A PHAGE DERIVED FAB FRAGMENT, IN COMPLEX WITH VEGF
Descriptor:Vascular endothelial growth factor A, Fab fragment light chain, Fab fragment heavy chain
Authors:Wiesmann, C.
Deposit date:2006-01-02
Release date:2006-02-07
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.
J.Biol.Chem., 281, 2006
2QR0
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STRUCTURE OF VEGF COMPLEXED TO A FAB CONTAINING TYR AND SER IN THE CDRS
Descriptor:Fab-Fragment Light and Heavy Chains, Vascular endothelial growth factor A
Authors:Wiesmann, C.
Deposit date:2007-07-27
Release date:2007-08-14
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries
J.Mol.Biol., 373, 2007
2VPF
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VASCULAR ENDOTHELIAL GROWTH FACTOR REFINED TO 1.93 ANGSTROMS RESOLUTION
Descriptor:VASCULAR ENDOTHELIAL GROWTH FACTOR
Authors:Muller, Y.A., De Vos, A.M.
Deposit date:1997-07-29
Release date:1998-07-29
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 A resolution: multiple copy flexibility and receptor binding.
Structure, 5, 1997
2VWE
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CRYSTAL STRUCTURE OF VASCULAR ENDOTHELIAL GROWTH FACTOR-B IN COMPLEX WITH A NEUTRALIZING ANTIBODY FAB FRAGMENT
Descriptor:VASCULAR ENDOTHELIAL GROWTH FACTOR B, ANTI-VEGF-B MONOCLONAL ANTIBODY
Authors:Leonard, P., Scotney, P.D., Jabeen, T., Iyer, S., Fabri, L.J., Nash, A.D., Acharya, K.R.
Deposit date:2008-06-23
Release date:2008-11-04
Modification date:2008-12-16
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal Structure of Vascular Endothelial Growth Factor-B in Complex with a Neutralising Antibody Fab Fragment.
J.Mol.Biol., 384, 2008
2XAC
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STRUCTURAL INSIGHTS INTO THE BINDING OF VEGF-B BY VEGFR-1D2: RECOGNITION AND SPECIFICITY
Descriptor:VASCULAR ENDOTHELIAL GROWTH FACTOR B, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1 (E.C.2.7.10.1)
Authors:Iyer, S., Darley, P., Acharya, K.R.
Deposit date:2010-03-30
Release date:2010-05-19
Modification date:2010-08-04
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structural Insights Into the Binding of Vegf-B by Vegfr-1D2: Recognition and Specificity
J.Biol.Chem., 285, 2010
2XV7
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CRYSTAL STRUCTURE OF VASCULAR ENDOTHELIAL GROWTH FACTOR D
Descriptor:VASCULAR ENDOTHELIAL GROWTH FACTOR D
Authors:Leppanen, V.-M., Jeltsch, M., Anisimov, A., Tvorogov, D., Aho, K., Kalkkinen, N., Toivanen, P., Yla-Herttuala, S., Ballmer-Hofer, K., Alitalo, K.
Deposit date:2010-10-23
Release date:2011-01-12
Modification date:2011-04-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Determinants of Vascular Endothelial Growth Factor-D - Receptor Binding and Specificity.
Blood, 117, 2011
3BDY
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DUAL SPECIFIC BH1 FAB IN COMPLEX WITH VEGF
Descriptor:VEGF, Fab Fragment -Heavy Chain, Vascular endothelial growth factor A
Authors:Bostrom, J.M., Wiesmann, C., Appleton, B.A.
Deposit date:2007-11-15
Release date:2008-11-18
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site
Science, 323, 2009
3P9W
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CRYSTAL STRUCTURE OF AN ENGINEERED HUMAN AUTONOMOUS VH DOMAIN IN COMPLEX WITH VEGF
Descriptor:Vascular endothelial growth factor, human VEGF-A
Authors:Ma, X., Wiesmann, C.
Deposit date:2010-10-18
Release date:2012-04-18
Modification date:2013-06-19
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Design of Synthetic Autonomous VH Domain Libraries and Structural Analysis of a VH Domain Bound to Vascular Endothelial Growth Factor.
J.Mol.Biol., 425, 2013
3QTK
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THE CRYSTAL STRUCTURE OF CHEMICALLY SYNTHESIZED VEGF-A
Descriptor:Vascular endothelial growth factor A
Authors:Mandal, K., Kent, S.B.H.
Deposit date:2011-02-22
Release date:2011-07-27
Modification date:2012-10-17
Method:X-RAY DIFFRACTION (1.849 Å)
Cite:Total chemical synthesis of biologically active vascular endothelial growth factor.
Angew.Chem.Int.Ed.Engl., 50, 2011
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