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1FLT
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1flt
VEGF IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR
Descriptor:VASCULAR ENDOTHELIAL GROWTH FACTOR, FMS-LIKE TYROSINE KINASE 1
Authors:Wiesmann, C., De Vos, A.M.
Deposit date:1997-11-20
Release date:1999-01-13
Modification date:2012-05-02
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor.
Cell(Cambridge,Mass.), 91, 1997
1FZV
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1fzv
THE CRYSTAL STRUCTURE OF HUMAN PLACENTA GROWTH FACTOR-1 (PLGF-1), AN ANGIOGENIC PROTEIN AT 2.0A RESOLUTION
Descriptor:PLACENTA GROWTH FACTOR
Authors:Iyer, S., Leonidas, D.D., Swaminathan, G.J., Maglione, D., Battisti, M., Tucci, M., Persico, M.G., Acharya, K.R.
Deposit date:2000-10-04
Release date:2001-05-09
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution.
J.Biol.Chem., 276, 2001
1KAT
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1kat
SOLUTION STRUCTURE OF A PHAGE-DERIVED PEPTIDE ANTAGONIST IN COMPLEX WITH VASCULAR ENDOTHELIAL GROWTH FACTOR
Descriptor:Vascular Endothelial Growth Factor/Phage-Derived Peptide Antagonist
Authors:Pan, B., Li, B., Russell, S.J., Tom, J.Y.K., Cochran, A.G., Fairbrother, W.J.
Deposit date:2001-11-02
Release date:2002-11-02
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution Structure of a Phage-derived Peptide Antagonist in Complex with Vascular Endothelial Growth Factor
J.Mol.Biol., 316, 2002
1MJV
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1mjv
DISULFIDE DEFICIENT MUTANT OF VASCULAR ENDOTHELIAL GROWTH FACTOR A (C51A AND C60A)
Descriptor:Vascular Endothelial Growth Factor A
Authors:Muller, Y.A., Heiring, C., Misselwitz, R., Welfle, K., Welfle, H.
Deposit date:2002-08-28
Release date:2002-12-11
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor
J.Biol.Chem., 277, 2002
1MKG
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1mkg
DISULFIDE DEFICIENT MUTANT OF VASCULAR ENDOTHELIAL GROWTH FACTOR A (C57A AND C102A)
Descriptor:Vascular Endothelial Growth Factor A
Authors:Muller, Y.A., Heiring, C., Misselwitz, R., Welfle, K., Welfle, H.
Deposit date:2002-08-29
Release date:2002-12-11
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor
J.Biol.Chem., 277, 2002
1MKK
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1mkk
DISULFIDE DEFICIENT MUTANT OF VASCULAR ENDOTHELIAL GROWTH FACTOR A (C61A AND C104A)
Descriptor:Vascular Endothelial Growth Factor A
Authors:Muller, Y.A., Heiring, C., Misselwitz, R., Welfle, K., Welfle, H.
Deposit date:2002-08-29
Release date:2002-12-11
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor
J.Biol.Chem., 277, 2002
1PDG
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1pdg
CRYSTAL STRUCTURE OF HUMAN PLATELET-DERIVED GROWTH FACTOR BB
Descriptor:PLATELET-DERIVED GROWTH FACTOR BB
Authors:Oefner, C., Darcy, A.D., Winkler, F.K., Eggimann, B., Hosnag, M.
Deposit date:1992-07-14
Release date:1994-01-31
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of human platelet-derived growth factor BB.
EMBO J., 11, 1992
1QTY
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1qty
VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR
Descriptor:VASCULAR ENDOTHELIAL GROWTH FACTOR
Authors:Wiesmann, C., de Vos, A.M.
Deposit date:1999-06-29
Release date:2000-01-12
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states.
J.Mol.Biol., 293, 1999
1RV6
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1rv6
CRYSTAL STRUCTURE OF PLGF IN COMPLEX WITH DOMAIN 2 OF VEGFR1
Descriptor:placenta growth factor (PlGF), FLT1 protein
Authors:Christinger, H.W., Fuh, G., de Vos, A.M., Wiesmann, C.
Deposit date:2003-12-12
Release date:2004-01-20
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1.
J.Biol.Chem., 279, 2004
1VPF
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1vpf
STRUCTURE OF HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR
Descriptor:VASCULAR ENDOTHELIAL GROWTH FACTOR
Authors:Muller, Y.A., De Vos, A.M.
Deposit date:1997-04-08
Release date:1998-04-08
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site.
Proc.Natl.Acad.Sci.USA, 94, 1997
1VPP
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1vpp
COMPLEX BETWEEN VEGF AND A RECEPTOR BLOCKING PEPTIDE
Descriptor:PROTEIN (VASCULAR ENDOTHELIAL GROWTH FACTOR)
Authors:Wiesmann, C., Christinger, H.W., Cochran, A.G., Cunningham, B.C., Fairbrother, W.J., Keenan, C.J., Meng, G., de Vos, A.M.
Deposit date:1998-10-09
Release date:1999-02-23
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the complex between VEGF and a receptor-blocking peptide.
Biochemistry, 37, 1998
1WQ8
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1wq8
CRYSTAL STRUCTURE OF VAMMIN, A VEGF-F FROM A SNAKE VENOM
Descriptor:Vascular endothelial growth factor toxin
Authors:Suto, K., Yamazaki, Y., Morita, T., Mizuno, H.
Deposit date:2004-09-23
Release date:2004-12-07
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of novel vascular endothelial growth factors (VEGF) from snake venoms: insight into selective VEGF binding to kinase insert domain-containing receptor but not to fms-like tyrosine kinase-1.
J.Biol.Chem., 280, 2005
2C7W
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2c7w
CRYSTAL STRUCTURE OF HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR-B: IDENTIFICATION OF AMINO ACIDS IMPORTANT FOR ANGIOGENINC ACTIVITY
Descriptor:VASCULAR ENDOTHELIAL GROWTH FACTOR B PRECURSOR
Authors:Iyer, S., Scotney, P.D., Nash, A.D., Acharya, K.R.
Deposit date:2005-11-29
Release date:2007-01-30
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Crystal Structure of Human Vascular Endothelial Growth Factor-B: Identification of Amino Acids Important for Receptor Binding
J.Mol.Biol., 359, 2006
2GNN
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2gnn
CRYSTAL STRUCTURE OF THE ORF VIRUS NZ2 VARIANT OF VEGF-E
Descriptor:Vascular endothelial growth factor homolog
Authors:Prota, A.E., Pieren, M., Wagner, A., Kostrewa, D., Winkler, F.K., Ballmer-Hofer, K.
Deposit date:2006-04-10
Release date:2006-05-09
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the Orf virus NZ2 variant of vascular endothelial growth factor-E. Implications for receptor specificity.
J.Biol.Chem., 281, 2006
2VPF
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2vpf
VASCULAR ENDOTHELIAL GROWTH FACTOR REFINED TO 1.93 ANGSTROMS RESOLUTION
Descriptor:VASCULAR ENDOTHELIAL GROWTH FACTOR
Authors:Muller, Y.A., De Vos, A.M.
Deposit date:1997-07-29
Release date:1998-07-29
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 A resolution: multiple copy flexibility and receptor binding.
Structure, 5, 1997
2XAC
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2xac
STRUCTURAL INSIGHTS INTO THE BINDING OF VEGF-B BY VEGFR-1D2: RECOGNITION AND SPECIFICITY
Descriptor:VASCULAR ENDOTHELIAL GROWTH FACTOR B, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1 (E.C.2.7.10.1)
Authors:Iyer, S., Darley, P., Acharya, K.R.
Deposit date:2010-03-30
Release date:2010-05-19
Modification date:2010-08-04
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structural Insights Into the Binding of Vegf-B by Vegfr-1D2: Recognition and Specificity
J.Biol.Chem., 285, 2010
2XV7
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2xv7
CRYSTAL STRUCTURE OF VASCULAR ENDOTHELIAL GROWTH FACTOR D
Descriptor:VASCULAR ENDOTHELIAL GROWTH FACTOR D
Authors:Leppanen, V.-M., Jeltsch, M., Anisimov, A., Tvorogov, D., Aho, K., Kalkkinen, N., Toivanen, P., Yla-Herttuala, S., Ballmer-Hofer, K., Alitalo, K.
Deposit date:2010-10-23
Release date:2011-01-12
Modification date:2011-04-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Determinants of Vascular Endothelial Growth Factor-D - Receptor Binding and Specificity.
Blood, 117, 2011
3QTK
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3qtk
THE CRYSTAL STRUCTURE OF CHEMICALLY SYNTHESIZED VEGF-A
Descriptor:Vascular endothelial growth factor A
Authors:Mandal, K., Kent, S.B.H.
Deposit date:2011-02-22
Release date:2011-07-27
Modification date:2012-10-17
Method:X-RAY DIFFRACTION (1.849 Å)
Cite:Total chemical synthesis of biologically active vascular endothelial growth factor.
Angew.Chem.Int.Ed.Engl., 50, 2011
3S1B
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3s1b
THE DEVELOPMENT OF PEPTIDE-BASED TOOLS FOR THE ANALYSIS OF ANGIOGENESIS
Descriptor:Vascular endothelial growth factor A, mini-Z
Authors:Murray, J.M., Wiesmann, C.
Deposit date:2011-05-14
Release date:2011-08-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The development of Peptide-based tools for the analysis of angiogenesis.
Chem.Biol., 18, 2011
4GLN
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4gln
CRYSTAL STRUCTURE OF CHEMICALLY SYNTHESIZED HETEROCHIRAL {D-PROTEIN ANTAGONIST PLUS VEGF-A} PROTEIN COMPLEX IN SPACE GROUP P21/N
Descriptor:D-RFX001, Vascular endothelial growth factor A
Authors:Mandal, K., Uppalapati, M., Ault-Riche, D., Kenney, J., Lowitz, J., Sidhu, S., Kent, S.B.H.
Deposit date:2012-08-14
Release date:2012-09-05
Modification date:2013-11-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography.
Proc.Natl.Acad.Sci.USA, 109, 2012
4HQU
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4hqu
CRYSTAL STRUCTURE OF HUMAN PDGF-BB IN COMPLEX WITH A MODIFIED NUCLEOTIDE APTAMER (SOMAMER SL5)
Descriptor:Platelet-derived growth factor subunit B/DNA complex
Authors:Davies, D.R., Edwards, T.E., Janjic, N., Gelinas, A.D., Zhang, C., Jarvis, T.C.
Deposit date:2012-10-26
Release date:2012-11-21
Modification date:2012-12-19
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets.
Proc.Natl.Acad.Sci.USA, 109, 2012
4HQX
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4hqx
CRYSTAL STRUCTURE OF HUMAN PDGF-BB IN COMPLEX WITH A MODIFIED NUCLEOTIDE APTAMER (SOMAMER SL4)
Descriptor:Platelet-derived growth factor subunit B/DNA complex
Authors:Davies, D.R., Edwards, T.E., Janjic, N., Gelinas, A.D., Zhang, C., Jarvis, T.C.
Deposit date:2012-10-26
Release date:2012-11-21
Modification date:2012-12-19
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets.
Proc.Natl.Acad.Sci.USA, 109, 2012
1WQ9
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1wq9
CRYSTAL STRUCTURE OF VR-1, A VEGF-F FROM A SNAKE VENOM
Descriptor:Vascular endothelial growth factor
Authors:Suto, K., Yamazaki, Y., Morita, T., Mizuno, H.
Deposit date:2004-09-24
Release date:2004-12-07
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of novel vascular endothelial growth factors (VEGF) from snake venoms: insight into selective VEGF binding to kinase insert domain-containing receptor but not to fms-like tyrosine kinase-1.
J.Biol.Chem., 280, 2005
1CZ8
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1cz8
VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY
Descriptor:VASCULAR ENDOTHELIAL GROWTH FACTOR/LIGHT CHAIN OF NEUTRALIZING ANTIBODY/HEAVY CHAIN OF NEUTRALIZING ANTIBODY COMPLEX
Authors:Chen, Y., Wiesmann, C., Fuh, G., Li, B., Christinger, H.W., McKay, P., de Vos, A.M., Lowman, H.B.
Deposit date:1999-09-01
Release date:2000-03-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen.
J.Mol.Biol., 293, 1999
1TZH
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1tzh
CRYSTAL STRUCTURE OF THE FAB YADS1 COMPLEXED WITH H-VEGF
Descriptor:Vascular endothelial growth factor A, Fab YADS1 Light Chain, Fab YADS1 Heavy Chain
Authors:Fellouse, F.A., Wiesmann, C., Sidhu, S.S.
Deposit date:2004-07-09
Release date:2004-08-31
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Synthetic antibodies from a four-amino-acid code: A dominant role for tyrosine in antigen recognition
Proc.Natl.Acad.Sci.USA, 101, 2004
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