4HQX
CRYSTAL STRUCTURE OF HUMAN PDGF-BB IN COMPLEX WITH A Modified nucleotide aptamer (SOMAmer SL4)
Summary for 4HQX
Entry DOI | 10.2210/pdb4hqx/pdb |
Related | 3MJG 4HQU |
Descriptor | Platelet-derived growth factor subunit B, SOMAmer SL4, SODIUM ION, ... (5 entities in total) |
Functional Keywords | growth factor, selex, aptamer, 5-modified deoxyuridine, hormone-dna complex, hormone/dna |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P01127 |
Total number of polymer chains | 2 |
Total formula weight | 20222.96 |
Authors | Davies, D.R.,Edwards, T.E.,Janjic, N.,Gelinas, A.D.,Zhang, C.,Jarvis, T.C. (deposition date: 2012-10-26, release date: 2012-11-21, Last modification date: 2023-09-20) |
Primary citation | Davies, D.R.,Gelinas, A.D.,Zhang, C.,Rohloff, J.C.,Carter, J.D.,O'Connell, D.,Waugh, S.M.,Wolk, S.K.,Mayfield, W.S.,Burgin, A.B.,Edwards, T.E.,Stewart, L.J.,Gold, L.,Janjic, N.,Jarvis, T.C. Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets. Proc.Natl.Acad.Sci.USA, 109:19971-19976, 2012 Cited by PubMed: 23139410DOI: 10.1073/pnas.1213933109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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