4HQU

Crystal structure of human PDGF-BB in complex with a modified nucleotide aptamer (SOMAmer SL5)

Summary for 4HQU

• Entry DOI: 10.2210/pdb4hqu/pdb
• Related: 3MJG 4HQX
• Descriptor: Platelet-derived growth factor subunit B, SOMAmer SL5, SODIUM ION, ... (5 entities in total)
• Functional Keywords: growth factor, selex, aptamer, 5-modified deoxyuridine, hormone-dna complex, hormone/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P01127
• Total number of polymer chains: 2
• Total formula weight: 20924.76

Authors

Davies, D.R.,Edwards, T.E.,Janjic, N.,Gelinas, A.D.,Zhang, C.,Jarvis, T.C. (deposition date: 2012-10-26, release date: 2012-11-21, Last modification date: 2023-09-20)

• Primary citation: Davies, D.R.,Gelinas, A.D.,Zhang, C.,Rohloff, J.C.,Carter, J.D.,O'Connell, D.,Waugh, S.M.,Wolk, S.K.,Mayfield, W.S.,Burgin, A.B.,Edwards, T.E.,Stewart, L.J.,Gold, L.,Janjic, N.,Jarvis, T.C.; Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets.; Proc.Natl.Acad.Sci.USA, 109:19971-19976, 2012; PubMed: 23139410; DOI: 10.1073/pnas.1213933109

Experimental method

X-RAY DIFFRACTION (2.2 Å)