4GLN

Crystal Structure of Chemically Synthesized Heterochiral {D-Protein Antagonist plus VEGF-A} Protein Complex in space group P21/n

Summary for 4GLN

Entry DOI	10.2210/pdb4gln/pdb
Related	3QTK 4GLS 4GLU
Descriptor	D-RFX001, Vascular endothelial growth factor A (3 entities in total)
Functional Keywords	heterochiral protein-protein complex, d-protein antagonist, growth factor-inhibitor complex, growth factor/inhibitor
Biological source	synthetic construct More
Total number of polymer chains	4
Total formula weight	36649.11
Authors	Mandal, K.,Uppalapati, M.,Ault-Riche, D.,Kenney, J.,Lowitz, J.,Sidhu, S.,Kent, S.B.H. (deposition date: 2012-08-14, release date: 2012-09-05, Last modification date: 2019-04-24)
Primary citation	Mandal, K.,Uppalapati, M.,Ault-Riche, D.,Kenney, J.,Lowitz, J.,Sidhu, S.S.,Kent, S.B. Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography. Proc.Natl.Acad.Sci.USA, 109:14779-14784, 2012 Cited by PubMed: 22927390 DOI: 10.1073/pnas.1210483109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation