2FJG
Structure of the G6 Fab, a phage derived Fab fragment, in complex with VEGF
Summary for 2FJG
Entry DOI | 10.2210/pdb2fjg/pdb |
Related | 1FLT 2FJF 2FJH |
Descriptor | Vascular endothelial growth factor A, Fab light chain, Fab heavy chain, ... (4 entities in total) |
Functional Keywords | protein fab complex, fab, vegf, cystine knot, hormone-growth factor-immune system complex, hormone/growth factor/immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: Q96NW5 |
Total number of polymer chains | 6 |
Total formula weight | 119405.57 |
Authors | Wiesmann, C. (deposition date: 2006-01-02, release date: 2006-02-07, Last modification date: 2023-08-30) |
Primary citation | Fuh, G.,Wu, P.,Liang, W.C.,Ultsch, M.,Lee, C.V.,Moffat, B.,Wiesmann, C. Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab. J.Biol.Chem., 281:6625-6631, 2006 Cited by PubMed: 16373345DOI: 10.1074/jbc.M507783200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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