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4GUM	Cystal structure of locked-trimer of human MIF Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor Authors: Fan, C, Lolis, E. Deposit date: 2012-08-29 Release date: 2013-07-03 Last modified: 2020-11-18 Method: X-RAY DIFFRACTION (2.33 Å) Cite: MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations. Proc.Natl.Acad.Sci.USA, 110, 2013
7KQX	MIF Y99C homotrimeric mutant Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Manjula, R, Georgios, P, Lolis, E.J. Deposit date: 2020-11-18 Release date: 2022-01-19 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.6 Å) Cite: A Cysteine Variant at an Allosteric Site Alters MIF Dynamics and Biological Function in Homo- and Heterotrimeric Assemblies. Front Mol Biosci, 9, 2022
4Z15	MIF in complex with 3-(2-furylmethyl)-2-thioxo-1,3-thiazolan-4-one Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, SULFATE ION Authors: Cho, T.Y. Deposit date: 2015-03-26 Release date: 2016-09-28 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural basis for decreased induction of class IB PI3-kinases expression by MIF inhibitors. J. Cell. Mol. Med., 21, 2017
4Z1T	MIF in complex with 4-[(4-oxo-2-thioxo-1,3-thiazolan-3-yl)methyl]benzonitrile Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, SULFATE ION Authors: Cho, T.Y. Deposit date: 2015-03-27 Release date: 2016-09-28 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structural basis for decreased induction of class IB PI3-kinases expression by MIF inhibitors. J. Cell. Mol. Med., 21, 2017
4Z1U	MIF in complex with 1-(4-methylphenyl)-3-phenylprop-2-yn-1-one Descriptor: GLYCEROL, Macrophage migration inhibitory factor, SULFATE ION Authors: Cho, T.Y. Deposit date: 2015-03-27 Release date: 2016-09-28 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structural basis for decreased induction of class IB PI3-kinases expression by MIF inhibitors. J. Cell. Mol. Med., 21, 2017
3L5V	Crystal structure of macrophage migration inhibitory factor (MIF) with glycerol at 1.70A resolution Descriptor: GLYCEROL, Macrophage migration inhibitory factor, SULFATE ION Authors: McLean, L, Zhang, Y. Deposit date: 2009-12-22 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010
3L5P	Crystal structure of macrophage migration inhibitory factor (MIF) with imidazopyridazinol inhibitor at 1.80A resolution Descriptor: 2-(1-methylethyl)imidazo[1,2-b]pyridazin-6-ol, GLYCEROL, Macrophage migration inhibitory factor, ... Authors: McLean, L, Zhang, Y. Deposit date: 2009-12-22 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010
7E4B	Crystal structure of MIF bound to compound 5 Descriptor: 2-[2,4-bis(oxidanyl)phenyl]-3,5,7-tris(oxidanyl)chromen-4-one, CHLORIDE ION, Macrophage migration inhibitory factor Authors: Fan, C.P, Guo, D.Y, Yang, L. Deposit date: 2021-02-11 Release date: 2023-02-15 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.772 Å) Cite: Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors. J.Agric.Food Chem., 69, 2021
7E49	Crystal structure of MIF bound to compound10 Descriptor: 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, CHLORIDE ION, Macrophage migration inhibitory factor Authors: Fan, C.P, Guo, D.Y, Yang, L. Deposit date: 2021-02-11 Release date: 2023-02-15 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.574 Å) Cite: Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors. J.Agric.Food Chem., 69, 2021
7E47	Crystal structure of compound 6 bound to MIF Descriptor: (2S,3R,4R,5R,6R)-2-[(2S,3R,4S,5R,6S)-6-(hydroxymethyl)-2-[[(2R,4R)-2-(4-hydroxyphenyl)-4,5-bis(oxidanyl)-3,4-dihydro-2H-chromen-7-yl]oxy]-4,5-bis(oxidanyl)oxan-3-yl]oxy-6-methyl-oxane-3,4,5-triol, CHLORIDE ION, Macrophage migration inhibitory factor Authors: Fan, C.P, Yang, L, Guo, D.Y. Deposit date: 2021-02-10 Release date: 2023-02-15 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.38 Å) Cite: Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors. J.Agric.Food Chem., 69, 2021
7E45	Crystal structure of compound 7 bound to MIF Descriptor: (2R)-7-[(2R,3R,4R,5S,6S)-6-(hydroxymethyl)-3-[(2R,3R,4R,5R,6S)-6-methyl-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-4,5-bis(oxidanyl)oxan-2-yl]oxy-2-(4-methoxy-3-oxidanyl-phenyl)-5-oxidanyl-2,3-dihydrochromen-4-one, CHLORIDE ION, Macrophage migration inhibitory factor Authors: Fan, C.P, Yang, L. Deposit date: 2021-02-10 Release date: 2023-02-15 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.433 Å) Cite: Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors. J.Agric.Food Chem., 69, 2021
7E4A	Crystal structure of MIF bound to compound 13 Descriptor: CHLORIDE ION, Flavoxate, Macrophage migration inhibitory factor, ... Authors: Fa, C.P, Guo, D.Y, Yang, L. Deposit date: 2021-02-11 Release date: 2023-02-15 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.475 Å) Cite: Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors. J.Agric.Food Chem., 69, 2021
7E4C	Crystal structure of MIF bound to compound11 Descriptor: 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol, CHLORIDE ION, Macrophage migration inhibitory factor, ... Authors: Fan, C.P, Guo, D.Y, Yang, L. Deposit date: 2021-02-11 Release date: 2023-02-15 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.644 Å) Cite: Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors. J.Agric.Food Chem., 69, 2021
3L5T	Crystal structure of macrophage migration inhibitory factor (MIF) with thiophenepiperazinylquinolinone inhibitor at 1.86A resolution Descriptor: 1-methyl-2-oxo-4-[4-(thiophen-2-ylcarbonyl)piperazin-1-yl]-1,2-dihydroquinoline-3-carbonitrile, Macrophage migration inhibitory factor, SULFATE ION Authors: McLean, L, Zhang, Y. Deposit date: 2009-12-22 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010
3L5R	Crystal structure of macrophage migration inhibitory factor (MIF) with phenylchromenone inhibitor at 1.94A resolution Descriptor: 3-(3,4-dihydroxyphenyl)-7-hydroxy-4H-chromen-4-one, GLYCEROL, Macrophage migration inhibitory factor, ... Authors: McLean, L, Zhang, Y. Deposit date: 2009-12-22 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010
3L5U	Crystal structure of macrophage migration inhibitory factor (MIF) with benzothiazole inhibitor at 1.90A resolution Descriptor: 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE, Macrophage migration inhibitory factor, SULFATE ION Authors: McLean, L, Zhang, Y. Deposit date: 2009-12-22 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010
3L5S	Crystal structure of macrophage migration inhibitory factor (MIF) with imidazopyrimidinylphenyl inhibitor at 1.86A resolution Descriptor: 5-ethyl-2-(phenylcarbonyl)imidazo[1,2-a]pyrimidin-7(1H)-one, Macrophage migration inhibitory factor, SULFATE ION Authors: McLean, L, Zhang, Y. Deposit date: 2009-12-22 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010
3JSF	Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 638 at 1.93a resolution Descriptor: 7-(2-fluorobenzyl)quinolin-8-ol, Macrophage migration inhibitory factor, SULFATE ION Authors: Mclean, L, Zhang, Y. Deposit date: 2009-09-10 Release date: 2009-11-10 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.93 Å) Cite: Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening. Bioorg.Med.Chem.Lett., 19, 2009
3JSG	Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 707 at 1.58a resolution Descriptor: 7-(pyridin-3-ylmethyl)quinolin-8-ol, Macrophage migration inhibitory factor, SULFATE ION Authors: Mclean, L, Zhang, Y. Deposit date: 2009-09-10 Release date: 2009-11-10 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening. Bioorg.Med.Chem.Lett., 19, 2009
3JTU	Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 708 at 1.86a resolution Descriptor: 7-(pyridin-2-ylmethyl)quinolin-8-ol, Macrophage migration inhibitory factor, SULFATE ION Authors: Mclean, L, Zhang, Y. Deposit date: 2009-09-14 Release date: 2009-11-10 Last modified: 2017-11-01 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening. Bioorg.Med.Chem.Lett., 19, 2009
4TRF	Crystal structure of Macrophage Migration Inhibitory Factor in complex with N-(pyridin-3-ylmethyl)thioformamide Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2014-06-16 Release date: 2015-09-30 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.63 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
4TRU	Crystal structure of Q24A Q25A mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2014-06-17 Release date: 2015-09-30 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.81 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
8CA0	Macrophage inhibitory factor (MIF) in complex with small molecule PAV174 Descriptor: 1-ethyl-9-methyl-3,7-dipyrrolidin-1-yl-phenothiazine, Macrophage migration inhibitory factor Authors: Mueller, A, Torres, F, Roland, R, Korth, C. Deposit date: 2023-01-24 Release date: 2024-02-07 Method: SOLUTION NMR Cite: Oxidized MIF is a drug target at the molecular intersection between immune activation and tau cellular pathology To Be Published
6OYB	Crystal structure of H62G mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2019-05-14 Release date: 2020-04-22 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel. Cell Chem Biol, 27, 2020
6OYE	Crystal structure of Y99F mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2019-05-14 Release date: 2020-04-29 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel. Cell Chem Biol, 27, 2020

 

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