3L5T
Crystal structure of macrophage migration inhibitory factor (MIF) with thiophenepiperazinylquinolinone inhibitor at 1.86A resolution
Summary for 3L5T
Entry DOI | 10.2210/pdb3l5t/pdb |
Related | 3L5P 3L5R 3L5S 3L5U 3L5V |
Descriptor | Macrophage migration inhibitory factor, 1-methyl-2-oxo-4-[4-(thiophen-2-ylcarbonyl)piperazin-1-yl]-1,2-dihydroquinoline-3-carbonitrile, SULFATE ION, ... (4 entities in total) |
Functional Keywords | protein-ligand complex, cytokine, cytoplasm, immune response, inflammatory response, innate immunity, isomerase, phosphoprotein, secreted, acetylation |
Biological source | Homo sapiens (human) |
Cellular location | Secreted : P14174 |
Total number of polymer chains | 3 |
Total formula weight | 40849.20 |
Authors | McLean, L.,Zhang, Y. (deposition date: 2009-12-22, release date: 2010-03-09, Last modification date: 2023-09-06) |
Primary citation | McLean, L.R.,Zhang, Y.,Li, H.,Choi, Y.M.,Han, Z.,Vaz, R.J.,Li, Y. Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20:1821-1824, 2010 Cited by PubMed: 20185308DOI: 10.1016/j.bmcl.2010.02.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.86 Å) |
Structure validation
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