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3LVP
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BU of 3lvp by Molmil
Crystal structure of bisphosphorylated IGF1-R Kinase domain (2P) in complex with a bis-azaindole inhibitor
Descriptor: 3-(4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Insulin-like growth factor 1 receptor, ...
Authors:Maignan, S, Marquette, J.P, Guilloteau, J.P.
Deposit date:2010-02-22
Release date:2010-07-21
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3 Å)
Cite:Design of Potent IGF1-R Inhibitors Related to Bis-azaindoles
Chem.Biol.Drug Des., 76, 2010
7YRR
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BU of 7yrr by Molmil
Cryo-EM structure of IGF1R with two IGF1 complex
Descriptor: Insulin-like growth factor 1 receptor, Isoform 3 of Insulin-like growth factor I
Authors:Xi, Z, Cang, W.
Deposit date:2022-08-10
Release date:2023-08-16
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Cryo-EM structure of IGF1R with two IGF1 complex at 4.3 angstroms resolution
To Be Published
3D94
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BU of 3d94 by Molmil
Crystal structure of the insulin-like growth factor-1 receptor kinase in complex with PQIP
Descriptor: 3-[cis-3-(4-methylpiperazin-1-yl)cyclobutyl]-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-amine, CALCIUM ION, Insulin-like growth factor 1 receptor beta chain
Authors:Wu, J, Li, W, Miller, W.T, Hubbard, S.R.
Deposit date:2008-05-26
Release date:2008-07-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor
Embo J., 27, 2008
7XGD
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BU of 7xgd by Molmil
Cryo-EM structure of Apo-IGF1R map 1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor 1 receptor
Authors:Zhang, X, Wu, C.
Deposit date:2022-04-04
Release date:2023-04-12
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structure of Apo-IGF1R
To Be Published
7XLC
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BU of 7xlc by Molmil
conformation II of apo-IGF1R states
Descriptor: Insulin-like growth factor 1 receptor
Authors:Xi, Z, Cang, W.
Deposit date:2022-04-21
Release date:2023-04-26
Method:ELECTRON MICROSCOPY (5 Å)
Cite:conformation II of apo-IGF1R states
To Be Published
7V3P
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BU of 7v3p by Molmil
Cryo-EM structure of the IGF1R/insulin complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ...
Authors:Zhang, J, Liu, C, Zhang, X, Wei, T, Wu, C.
Deposit date:2021-08-11
Release date:2022-08-17
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of the IGF1R/insulin complex
To Be Published
8PYI
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BU of 8pyi by Molmil
Human IGF1R with inhibitor 6
Descriptor: 3-[8-azanyl-1-(4-ethoxy-8-fluoranyl-2-phenyl-quinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl-cyclobutan-1-ol, Insulin-like growth factor 1 receptor beta chain
Authors:Dreyer, M.K, Wang, J, Elkins, J.M.
Deposit date:2023-07-25
Release date:2023-09-20
Method:X-RAY DIFFRACTION (3.06 Å)
Cite:Human IGF1R with inhibitor 6
To Be Published
8PYJ
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BU of 8pyj by Molmil
Human IGF1R with inhibitor 8
Descriptor: 5,5-dimethyl-1-(quinolin-4-ylmethyl)-3-[4-(trifluoromethylsulfonyl)phenyl]imidazolidine-2,4-dione, CADMIUM ION, Insulin-like growth factor 1 receptor beta chain, ...
Authors:Dreyer, M.K, Wang, J, Elkins, J.M.
Deposit date:2023-07-25
Release date:2023-09-20
Method:X-RAY DIFFRACTION (2.702 Å)
Cite:Human IGF1R with inhibitor 8
To Be Published
8PYK
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BU of 8pyk by Molmil
Human IGF1R with inhibitor 47
Descriptor: 5,5-dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dione, Insulin-like growth factor 1 receptor beta chain, NICKEL (II) ION
Authors:Dreyer, M.K, Wang, J, Elkins, J.M.
Deposit date:2023-07-25
Release date:2023-09-20
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Human IGF1R with inhibitor 47
To Be Published
8PYN
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BU of 8pyn by Molmil
Human IGF1R with inhibitor 56
Descriptor: 5,5-dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfonyl)phenyl]imidazolidine-2,4-dione, CADMIUM ION, Insulin-like growth factor 1 receptor beta chain, ...
Authors:Dreyer, M.K, Wang, J, Elkins, J.M.
Deposit date:2023-07-25
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Human IGF1R with inhibitor 56
To Be Published
8PYL
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BU of 8pyl by Molmil
Human IGF1R with inhibitor 53
Descriptor: (5S)-5-methyl-1-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dione, CADMIUM ION, Insulin-like growth factor 1 receptor beta chain, ...
Authors:Dreyer, M.K, Wang, J, Elkins, J.M.
Deposit date:2023-07-25
Release date:2023-09-20
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Human IGF1R with inhibitor 53
To Be Published
8PYM
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BU of 8pym by Molmil
Human IGF1R with inhibitor 54
Descriptor: 5,5-dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dione, CADMIUM ION, Insulin-like growth factor 1 receptor beta chain, ...
Authors:Dreyer, M.K, Wang, J, Elkins, J.M.
Deposit date:2023-07-25
Release date:2023-09-20
Method:X-RAY DIFFRACTION (2.652 Å)
Cite:Human IGF1R with inhibitor 54
To Be Published
8TAN
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BU of 8tan by Molmil
CryoEM structure of MFRV-VILP bound to IGF1Rzip
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor, ...
Authors:Kirk, N.S.
Deposit date:2023-06-27
Release date:2024-01-17
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression.
Mol Metab, 80, 2024
6PYH
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BU of 6pyh by Molmil
Cryo-EM structure of full-length IGF1R-IGF1 complex. Only the extracellular region of the complex is resolved.
Descriptor: Insulin-like growth factor 1 receptor, Insulin-like growth factor I
Authors:Li, J, Choi, E, Yu, H.T, Bai, X.C.
Deposit date:2019-07-29
Release date:2019-10-23
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural basis of the activation of type 1 insulin-like growth factor receptor.
Nat Commun, 10, 2019
8EYR
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BU of 8eyr by Molmil
Cryo-EM structure of two IGF1 bound full-length mouse IGF1R mutant (four glycine residues inserted in the alpha-CT; IGF1R-P674G4): symmetric conformation
Descriptor: Insulin-like growth factor 1 receptor, Insulin-like growth factor I
Authors:Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E.
Deposit date:2022-10-28
Release date:2022-11-09
Last modified:2022-12-07
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor.
Elife, 11, 2022
4XLV
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BU of 4xlv by Molmil
Crystal structure of the activated insulin receptor tyrosine kinase dimer
Descriptor: Insulin receptor, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Hubbard, S.R, Li, S.
Deposit date:2015-01-13
Release date:2015-03-25
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The insulin and IGF1 receptor kinase domains are functional dimers in the activated state.
Nat Commun, 6, 2015
5E1S
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BU of 5e1s by Molmil
The Crystal structure of INSR Tyrosine Kinase in complex with the Inhibitor BI 885578
Descriptor: (5R)-N-(1-{2-[4-(2-methoxyethyl)piperazin-1-yl]ethyl}-1H-pyrazol-3-yl)-5,8-dimethyl-9-phenyl-6,8-dihydro-5H-pyrazolo[3,4-h]quinazolin-2-amine, Insulin receptor
Authors:Kessler, D, Zahn, S, Sanderson, M, Wolkerstorfer, B.
Deposit date:2015-09-30
Release date:2015-10-14
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.264 Å)
Cite:BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis.
Mol.Cancer Ther., 14, 2015
1K3A
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BU of 1k3a by Molmil
Structure of the Insulin-like Growth Factor 1 Receptor Kinase
Descriptor: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, insulin receptor substrate 1, insulin-like growth factor 1 receptor
Authors:Favelyukis, S, Till, J.H, Hubbard, S.R, Miller, W.T.
Deposit date:2001-10-02
Release date:2001-11-28
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and autoregulation of the insulin-like growth factor 1 receptor kinase.
Nat.Struct.Biol., 8, 2001
3O23
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BU of 3o23 by Molmil
Human unphosphorylated IGF1-R Kinase domain in complex with an hydantoin inhibitor
Descriptor: (5S)-5-methyl-1-(quinolin-4-ylmethyl)-3-{4-[(trifluoromethyl)sulfonyl]phenyl}imidazolidine-2,4-dione, Insulin-like growth factor 1 receptor
Authors:Maignan, S, Guilloteau, J.P, Dupuy, A.
Deposit date:2010-07-22
Release date:2011-05-04
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of the first non-ATP competitive IGF-1R kinase inhibitors: Advantages in comparison with competitive inhibitors
Bioorg.Med.Chem.Lett., 21, 2011
7U23
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BU of 7u23 by Molmil
Single-chain LCDV-1 viral insulin-like peptide bound to IGF-1R ectodomain, leucine-zippered form
Descriptor: Insulin-like growth factor 1 receptor, single-chain LCDV-1 viral insulin-like peptide
Authors:Kirk, N.S, Lawrence, M.C.
Deposit date:2022-02-22
Release date:2022-11-16
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist.
Nat Commun, 13, 2022
7WRQ
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BU of 7wrq by Molmil
Structure of Human IGF1/IGFBP3/ALS Ternary Complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor-binding protein 3, Insulin-like growth factor-binding protein complex acid labile subunit, ...
Authors:Kim, H, Fu, Y, Kim, H.M.
Deposit date:2022-01-27
Release date:2022-08-10
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex
Nat Commun, 13, 2022
2DSQ
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BU of 2dsq by Molmil
Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins
Descriptor: Insulin-like growth factor IB, Insulin-like growth factor-binding protein 1, Insulin-like growth factor-binding protein 4
Authors:Sitar, T, Popowicz, G.M, Siwanowicz, I, Huber, R, Holak, T.A.
Deposit date:2006-07-05
Release date:2006-08-22
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2DSR
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BU of 2dsr by Molmil
Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins
Descriptor: Insulin-like growth factor IB, Insulin-like growth factor-binding protein 4
Authors:Sitar, T, Popowicz, G.M, Siwanowicz, I, Huber, R, Holak, T.A.
Deposit date:2006-07-05
Release date:2006-08-22
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2DSP
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BU of 2dsp by Molmil
Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins
Descriptor: Insulin-like growth factor IB, Insulin-like growth factor-binding protein 4
Authors:Sitar, T, Popowicz, G.M, Siwanowicz, I, Huber, R, Holak, T.A.
Deposit date:2006-07-05
Release date:2006-08-22
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.
Proc.Natl.Acad.Sci.Usa, 103, 2006
7S0Q
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BU of 7s0q by Molmil
Head region of a complex of IGF-I with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor, ...
Authors:Xu, Y, Lawrence, M.C.
Deposit date:2021-08-30
Release date:2022-07-06
Last modified:2022-08-17
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor.
Structure, 30, 2022

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