3O23
Human unphosphorylated IGF1-R Kinase domain in complex with an hydantoin inhibitor
Summary for 3O23
Entry DOI | 10.2210/pdb3o23/pdb |
Related | 3LVP |
Descriptor | Insulin-like growth factor 1 receptor, (5S)-5-methyl-1-(quinolin-4-ylmethyl)-3-{4-[(trifluoromethyl)sulfonyl]phenyl}imidazolidine-2,4-dione (3 entities in total) |
Functional Keywords | protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P08069 |
Total number of polymer chains | 1 |
Total formula weight | 35258.34 |
Authors | Maignan, S.,Guilloteau, J.P.,Dupuy, A. (deposition date: 2010-07-22, release date: 2011-05-04, Last modification date: 2023-11-01) |
Primary citation | Lesuisse, D.,Mauger, J.,Nemecek, C.,Maignan, S.,Boiziau, J.,Harlow, G.,Hittinger, A.,Ruf, S.,Strobel, H.,Nair, A.,Ritter, K.,Malleron, J.L.,Dagallier, A.,El-Ahmad, Y.,Guilloteau, J.P.,Guizani, H.,Bouchard, H.,Venot, C. Discovery of the first non-ATP competitive IGF-1R kinase inhibitors: Advantages in comparison with competitive inhibitors Bioorg.Med.Chem.Lett., 21:2224-2228, 2011 Cited by PubMed: 21441024DOI: 10.1016/j.bmcl.2011.03.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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