3LVP

Crystal structure of bisphosphorylated IGF1-R Kinase domain (2P) in complex with a bis-azaindole inhibitor

Summary for 3LVP

Entry DOI	10.2210/pdb3lvp/pdb
Descriptor	Insulin-like growth factor 1 receptor, 3-(4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (5 entities in total)
Functional Keywords	protein kinase, tyrosine kinase, tyrosine phosphorylation, protein-substrate complex, transferase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P08069
Total number of polymer chains	4
Total formula weight	155678.17
Authors	Maignan, S.,Marquette, J.P.,Guilloteau, J.P. (deposition date: 2010-02-22, release date: 2010-07-21, Last modification date: 2023-11-01)
Primary citation	Nemecek, C.,Metz, W.A.,Wentzler, S.,Ding, F.X.,Venot, C.,Souaille, C.,Dagallier, A.,Maignan, S.,Guilloteau, J.P.,Bernard, F.,Henry, A.,Grapinet, S.,Lesuisse, D. Design of Potent IGF1-R Inhibitors Related to Bis-azaindoles Chem.Biol.Drug Des., 76:100-106, 2010 Cited by PubMed: 20545947 DOI: 10.1111/j.1747-0285.2010.00991.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation