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4Y18
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Structure of BRCA1 BRCT domains in complex with Abraxas double phosphorylated peptide
Descriptor: BRCA1-A complex subunit Abraxas, Breast cancer type 1 susceptibility protein
Authors:Wu, Q, Blundell, T.L.
Deposit date:2015-02-06
Release date:2016-01-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites.
Mol.Cell, 61, 2016
4Y2G
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BU of 4y2g by Molmil
Structure of BRCA1 BRCT domains in complex with Abraxas single phosphorylated peptide
Descriptor: BRCA1-A complex subunit Abraxas, Breast cancer type 1 susceptibility protein
Authors:Wu, Q, Blundell, T.L.
Deposit date:2015-02-09
Release date:2016-01-27
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites.
Mol.Cell, 61, 2016
1L0B
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BU of 1l0b by Molmil
Crystal Structure of rat Brca1 tandem-BRCT region
Descriptor: BRCA1
Authors:Joo, W.S, Jeffrey, P.D, Cantor, S.B, Finnin, M.S, Livingston, D.M, Pavletich, N.P.
Deposit date:2002-02-08
Release date:2002-03-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure.
Genes Dev., 16, 2002
1T15
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BU of 1t15 by Molmil
Crystal Structure of the Brca1 BRCT Domains in Complex with the Phosphorylated Interacting Region from Bach1 Helicase
Descriptor: BRCA1 interacting protein C-terminal helicase 1, Breast cancer type 1 susceptibility protein
Authors:Clapperton, J.A, Manke, I.A, Lowery, D.M, Ho, T, Haire, L.F, Yaffe, M.B, Smerdon, S.J.
Deposit date:2004-04-15
Release date:2004-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer
Nat.Struct.Mol.Biol., 11, 2004
7JZV
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BU of 7jzv by Molmil
Cryo-EM structure of the BRCA1-UbcH5c/BARD1 E3-E2 module bound to a nucleosome
Descriptor: BRCA1,Ubiquitin-conjugating enzyme E2 D3, BRCA1-associated RING domain protein 1, Histone H2A type 2-A, ...
Authors:Witus, S.R, Burrell, A.L, Hansen, J.M, Farrell, D.P, Dimaio, F, Kollman, J.M, Klevit, R.E.
Deposit date:2020-09-02
Release date:2021-02-17
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1.
Nat.Struct.Mol.Biol., 28, 2021
7LYB
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BU of 7lyb by Molmil
Cryo-EM structure of the human nucleosome core particle in complex with BRCA1-BARD1-UbcH5c
Descriptor: BRCA1-associated RING domain protein 1, DNA (146-MER), DNA (147-MER), ...
Authors:Hu, Q, Botuyan, M.V, Zhao, D, Cui, D, Mer, E, Mer, G.
Deposit date:2021-03-06
Release date:2021-07-28
Last modified:2021-09-01
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation.
Nature, 596, 2021
1JM7
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BU of 1jm7 by Molmil
Solution structure of the BRCA1/BARD1 RING-domain heterodimer
Descriptor: BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1, BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN, ZINC ION
Authors:Brzovic, P.S, Rajagopal, P, Hoyt, D.W, King, M.-C, Klevit, R.E.
Deposit date:2001-07-17
Release date:2001-10-03
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.
Nat.Struct.Biol., 8, 2001
1OQA
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BU of 1oqa by Molmil
Solution structure of the BRCT-c domain from human BRCA1
Descriptor: Breast cancer type 1 susceptibility protein
Authors:Gaiser, O.J, Ball, L.J, Schmieder, P, Leitner, D, Strauss, H, Wahl, M, Kuhne, R, Oschkinat, H, Heinemann, U.
Deposit date:2003-03-07
Release date:2004-06-15
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution structure, backbone dynamics, and association behavior of the C-terminal BRCT domain from the breast cancer-associated protein BRCA1.
Biochemistry, 43, 2004
4U4A
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BU of 4u4a by Molmil
Complex Structure of BRCA1 BRCT with singly phospho Abraxas
Descriptor: BRCA1-A complex subunit Abraxas, Breast cancer type 1 susceptibility protein
Authors:Badgujar, D, Hosur, M.V, Varma, A.K.
Deposit date:2014-07-23
Release date:2015-08-26
Method:X-RAY DIFFRACTION (3.51 Å)
Cite:Complex Structure of BRCA1 BRCT with singly phospho Abraxas
To Be Published
4JLU
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BU of 4jlu by Molmil
Crystal structure of BRCA1 BRCT with doubly phosphorylated Abraxas
Descriptor: BRCA1-A complex subunit Abraxas, Breast cancer type 1 susceptibility protein
Authors:Badgujar, D, Varma, A.K.
Deposit date:2013-03-13
Release date:2014-09-10
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structure of BRCA1 BRCT with doubly phosphorylated Abraxas
To be Published
7E8I
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BU of 7e8i by Molmil
Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin
Descriptor: BRCA1-associated RING domain protein 1, DNA (145-MER), Histone H2A, ...
Authors:Dai, Y, Dai, L, Zhou, Z.
Deposit date:2021-03-01
Release date:2021-06-30
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin.
Mol.Cell, 81, 2021
1Y98
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BU of 1y98 by Molmil
Structure of the BRCT repeats of BRCA1 bound to a CtIP phosphopeptide.
Descriptor: Breast cancer type 1 susceptibility protein, COBALT (II) ION, CtIP PHOSPHORYLATED PEPTIDE, ...
Authors:Varma, A.K, Brown, R.S, Birrane, G, Ladias, J.A.A.
Deposit date:2004-12-14
Release date:2005-08-30
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for Cell Cycle Checkpoint Control by the BRCA1-CtIP Complex.
Biochemistry, 44, 2005
7K3S
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BU of 7k3s by Molmil
Solution NMR Structure of the Coiled-coil BRCA1-PALB2 Heterodimer
Descriptor: Breast cancer type 1 susceptibility protein homolog, Partner and localizer of BRCA2
Authors:Daigham, N.S, Liu, G, Bunting, S.F, Montelione, G.T.
Deposit date:2020-09-13
Release date:2021-09-29
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:The Structural Basis for Interactions Between PALB2 and BRCA1 that Mediate the Homologous Recombination DNA Damage Repair Process
To Be Published
1N5O
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BU of 1n5o by Molmil
Structural consequences of a cancer-causing BRCA1-BRCT missense mutation
Descriptor: Breast cancer type 1 susceptibility protein, COBALT (II) ION, SULFATE ION
Authors:Williams, R.S, Glover, J.N.M.
Deposit date:2002-11-06
Release date:2002-12-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural consequences of a cancer-causing BRCA1-BRCT missense mutation
J.Biol.Chem., 278, 2003
1T29
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BU of 1t29 by Molmil
Crystal structure of the BRCA1 BRCT repeats bound to a phosphorylated BACH1 peptide
Descriptor: BACH1 phosphorylated peptide, Breast cancer type 1 susceptibility protein
Authors:Shiozaki, E.N, Gu, L, Yan, N, Shi, Y.
Deposit date:2004-04-20
Release date:2004-05-11
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling.
Mol.Cell, 14, 2004
4OFB
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BU of 4ofb by Molmil
Crystal structure of human BRCA1 BRCT in complex with nonphosphopeptide inhibitor
Descriptor: Breast cancer type 1 susceptibility protein, nonphosphopeptide inhibitor
Authors:Sun, L, Edwards, R.A, Glover, J.N.M.
Deposit date:2014-01-14
Release date:2015-04-15
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Peptide Library Approach to Uncover Phosphomimetic Inhibitors of the BRCA1 C-Terminal Domain.
Acs Chem.Biol., 10, 2015
1T2U
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BU of 1t2u by Molmil
Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1: structure of BRCA1 missense variant V1809F
Descriptor: Breast cancer type 1 susceptibility protein, COBALT (II) ION, SULFATE ION
Authors:Williams, R.S, Lee, M.S, Duong, D.D, Glover, J.N.M.
Deposit date:2004-04-22
Release date:2004-05-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis of Phosphopeptide recognition by the BRCT domain of BRCA1
Nat.Struct.Mol.Biol., 11, 2004
3PXE
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BU of 3pxe by Molmil
Impact of BRCA1 BRCT domain missense substitutions on phospho-peptide recognition: E1836K
Descriptor: Breast cancer type 1 susceptibility protein, phospho peptide
Authors:Coquelle, N, Green, R, Glover, J.N.M.
Deposit date:2010-12-09
Release date:2011-04-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition.
Biochemistry, 50, 2011
1T2V
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BU of 1t2v by Molmil
Structural basis of phospho-peptide recognition by the BRCT domain of BRCA1, structure with phosphopeptide
Descriptor: BRCTide-7PS, Breast cancer type 1 susceptibility protein
Authors:Williams, R.S, Lee, M.S, Hau, D.D, Glover, J.N.M.
Deposit date:2004-04-22
Release date:2004-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1
Nat.Struct.Mol.Biol., 11, 2004
3PXB
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BU of 3pxb by Molmil
Impact of BRCA1 BRCT domain missense substitutions on phospho-peptide recognition: T1700A
Descriptor: Breast cancer type 1 susceptibility protein, NICKEL (II) ION, SULFATE ION
Authors:Coquelle, N, Green, R, Glover, J.N.M.
Deposit date:2010-12-09
Release date:2011-04-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition.
Biochemistry, 50, 2011
3PXD
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BU of 3pxd by Molmil
Impact of BRCA1 BRCT domain missense substitutions on phospho-peptide recognition: R1835P
Descriptor: Breast cancer type 1 susceptibility protein, NICKEL (II) ION, SULFATE ION
Authors:Coquelle, N, Green, R, Glover, J.N.M.
Deposit date:2010-12-09
Release date:2011-04-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition.
Biochemistry, 50, 2011
3PXA
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BU of 3pxa by Molmil
Impact of BRCA1 BRCT domain missense substitutions on phospho-peptide recognition: G1656D
Descriptor: Breast cancer type 1 susceptibility protein, NICKEL (II) ION, SULFATE ION
Authors:Coquelle, N, Green, R, Glover, J.N.M.
Deposit date:2010-12-09
Release date:2011-04-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition.
Biochemistry, 50, 2011
3PXC
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BU of 3pxc by Molmil
Impact of BRCA1 BRCT domain missense substitutions on phospho-peptide recognition: R1699Q
Descriptor: Breast cancer type 1 susceptibility protein, NICKEL (II) ION, SULFATE ION
Authors:Coquelle, N, Green, R, Glover, J.N.M.
Deposit date:2010-12-09
Release date:2011-04-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition.
Biochemistry, 50, 2011
8OFF
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BU of 8off by Molmil
Structure of BARD1 ARD-BRCTs in complex with H2AKc15ub nucleosomes (Map1)
Descriptor: BRCA1 associated RING domain 1, DNA (142-MER), Histone H2A type 1, ...
Authors:Foglizzo, M, Burdett, H, Wilson, M.D, Zeqiraj, E.
Deposit date:2023-03-15
Release date:2023-10-11
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:BRCA1-BARD1 combines multiple chromatin recognition modules to bridge nascent nucleosomes.
Nucleic Acids Res., 51, 2023
2ING
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BU of 2ing by Molmil
X-ray Structure of the BRCA1 BRCT mutant M1775K
Descriptor: Breast cancer type 1 susceptibility protein, COBALT (II) ION, SULFATE ION
Authors:Birrane, G, Soni, A, Ladias, J.A.A.
Deposit date:2006-10-07
Release date:2007-09-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach.
Eur.J.Hum.Genet., 16, 2008

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