7JZV

Cryo-EM structure of the BRCA1-UbcH5c/BARD1 E3-E2 module bound to a nucleosome

Summary for 7JZV

Entry DOI	10.2210/pdb7jzv/pdb
EMDB information	22581
Descriptor	BRCA1,Ubiquitin-conjugating enzyme E2 D3, BRCA1-associated RING domain protein 1, Histone H2A type 2-A, ... (9 entities in total)
Functional Keywords	complex, ubiquitin, nucleosome, ring, ligase, ligase-dna complex, ligase/dna
Biological source	Homo sapiens (Human) More
Total number of polymer chains	12
Total formula weight	245918.93
Authors	Witus, S.R.,Burrell, A.L.,Hansen, J.M.,Farrell, D.P.,Dimaio, F.,Kollman, J.M.,Klevit, R.E. (deposition date: 2020-09-02, release date: 2021-02-17, Last modification date: 2024-03-06)
Primary citation	Witus, S.R.,Burrell, A.L.,Farrell, D.P.,Kang, J.,Wang, M.,Hansen, J.M.,Pravat, A.,Tuttle, L.M.,Stewart, M.D.,Brzovic, P.S.,Chatterjee, C.,Zhao, W.,DiMaio, F.,Kollman, J.M.,Klevit, R.E. BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1. Nat.Struct.Mol.Biol., 28:268-277, 2021 Cited by PubMed: 33589814 DOI: 10.1038/s41594-020-00556-4 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.9 Å)

Structure validation