4Y2G
Structure of BRCA1 BRCT domains in complex with Abraxas single phosphorylated peptide
Summary for 4Y2G
| Entry DOI | 10.2210/pdb4y2g/pdb |
| Descriptor | Breast cancer type 1 susceptibility protein, BRCA1-A complex subunit Abraxas (3 entities in total) |
| Functional Keywords | dna damage response, brct, phosphopeptide, ligase-peptide complex, antitumor protein |
| Biological source | Homo sapiens (Human) More |
| Cellular location | Nucleus . Isoform 3: Cytoplasm. Isoform 5: Cytoplasm : P38398 Nucleus : Q6UWZ7 |
| Total number of polymer chains | 2 |
| Total formula weight | 26734.58 |
| Authors | Wu, Q.,Blundell, T.L. (deposition date: 2015-02-09, release date: 2016-01-27, Last modification date: 2016-02-17) |
| Primary citation | Wu, Q.,Paul, A.,Su, D.,Mehmood, S.,Foo, T.K.,Ochi, T.,Bunting, E.L.,Xia, B.,Robinson, C.V.,Wang, B.,Blundell, T.L. Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites. Mol.Cell, 61:434-448, 2016 Cited by PubMed: 26778126DOI: 10.1016/j.molcel.2015.12.017 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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