4Y18
Structure of BRCA1 BRCT domains in complex with Abraxas double phosphorylated peptide
Summary for 4Y18
Entry DOI | 10.2210/pdb4y18/pdb |
Descriptor | Breast cancer type 1 susceptibility protein, BRCA1-A complex subunit Abraxas (3 entities in total) |
Functional Keywords | dna damage response, brct, phosphopeptide, ligase-peptide complex, antitumor protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 16 |
Total formula weight | 217639.58 |
Authors | Wu, Q.,Blundell, T.L. (deposition date: 2015-02-06, release date: 2016-01-27, Last modification date: 2024-01-10) |
Primary citation | Wu, Q.,Paul, A.,Su, D.,Mehmood, S.,Foo, T.K.,Ochi, T.,Bunting, E.L.,Xia, B.,Robinson, C.V.,Wang, B.,Blundell, T.L. Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites. Mol.Cell, 61:434-448, 2016 Cited by PubMed: 26778126DOI: 10.1016/j.molcel.2015.12.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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