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2C2K
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BU of 2c2k by Molmil
Crystal structures of caspase-3 in complex with aza-peptide Michael acceptor inhibitors.
Descriptor: AZA-PEPTIDE INHIBITOR (5S, 8R, 11S)-8-(2-CARBOXYETHYL)-5-(CARBOXYMETHYL)-14-(4-ETHOXY-4-OXOBUTANOYL)-11-(1-METHYLETHYL)-3,6,9,12-TETRAOXO-1-PHENYL-2-OXA-4,7,10,13,14-PENTAAZAHEXADECAN -16-OIC ACID, ...
Authors:Ganesan, R, Jelakovic, S, Ekici, O.D, Li, Z.Z, James, K.E, Asgian, J.L, Campbell, A.J, Mikolajczyk, J, Salvesen, G.S, Gruetter, M.G, Powers, J.C.
Deposit date:2005-09-29
Release date:2006-09-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Selective and Potent Inhibitors of Caspases-2, -3, -6, -7, -8, -9, and - 10.
J.Med.Chem., 49, 2006
2C2Z
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Crystal structure of caspase-8 in complex with aza-peptide Michael acceptor inhibitor
Descriptor: AZA-PEPTIDE INHIBITOR (5S, 8R, 11S)-8-(2-CARBOXYETHYL) -14-[4-(3,4-DIHYDROQUINOLIN-1(2H)-YL)-4-OXOBUTANOYL] -11-[(1R)-1-HYDROXYETHYL]-5-(2-METHYLPROPYL)-3,6,9,12-TETRAOXO -1-PHENYL-2-OXA-4,7,10,13,14-PENTAAZAHEXADECAN-16-OIC ACID, ...
Authors:Ganesan, R, Jelakovic, S, Ekici, O.D, Li, Z.Z, James, K.E, Asgian, J.L, Campbell, A.J, Mikolajczyk, J, Salvesen, G.S, Powers, J.C, Gruetter, M.G.
Deposit date:2005-10-02
Release date:2006-09-20
Last modified:2017-02-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Selective and Potent Inhibitors of Caspases-2, -3, -6, -7, -8, -9, and - 10.
J.Med.Chem., 49, 2006
2CJX
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BU of 2cjx by Molmil
Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis
Descriptor: CASPASE-3, PHQ-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE
Authors:Ganesan, R, Mittl, P.R.E, Jelakovic, S, Grutter, M.G.
Deposit date:2006-04-09
Release date:2006-06-27
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Extended Substrate Recognition in Caspase-3 Revealed by High Resolution X-Ray Structure Analysis
J.Mol.Biol., 359, 2006
2AR9
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BU of 2ar9 by Molmil
Crystal structure of a dimeric caspase-9
Descriptor: Caspase-9, D-MALATE
Authors:Chao, Y, Shiozaki, E.N, Srinivassula, S.M, Rigotti, D.J, Fairman, R, Shi, Y.
Deposit date:2005-08-19
Release date:2005-10-11
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Engineering a Dimeric Caspase-9: A Re-Evaluation of the Induced Proximity Model for Caspase Activation
PLOS BIOL., 3, 2005
2DKO
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BU of 2dko by Molmil
Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis
Descriptor: Caspase-3, PHQ-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE
Authors:Mittl, P.R.E, Ganesan, R, Jelakovic, S, Grutter, M.G.
Deposit date:2006-04-12
Release date:2006-07-04
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.06 Å)
Cite:Extended Substrate Recognition in Caspase-3 Revealed by High Resolution X-ray Structure Analysis
J.Mol.Biol., 359, 2006
2CNO
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BU of 2cno by Molmil
Crystal structures of caspase-3 in complex with aza-peptide epoxide inhibitors.
Descriptor: Aza-peptide epoxide, Caspase-3
Authors:Ganesan, R, Jelakovic, S, Campbell, A.J, Li, Z.Z, Asgian, J.L, Powers, J.C, Grutter, M.G.
Deposit date:2006-05-22
Release date:2007-05-22
Last modified:2024-07-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Exploring the S4 and S1 Prime Subsite Specificities in Caspase-3 with Aza-Peptide Epoxide Inhibitors
Biochemistry, 45, 2006
2CDR
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BU of 2cdr by Molmil
Crystal structures of caspase-3 in complex with aza-peptide epoxide inhibitors.
Descriptor: AZA-PEPTIDE EXPOXIDE, CASPASE-3 SUBUNIT P12, CASPASE-3 SUBUNIT P17
Authors:Ganesan, R, Jelakovic, S, Campbell, A.J, Li, Z.Z, Asgian, J.L, Powers, J.C, Gruetter, M.G.
Deposit date:2006-01-27
Release date:2007-03-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Exploring the S4 and S1 Prime Subsite Specificities in Caspase-3 with Aza-Peptide Epoxide Inhibitors.
Biochemistry, 45, 2006
2CNN
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BU of 2cnn by Molmil
Crystal structures of caspase-3 in complex with aza-peptide epoxide inhibitors.
Descriptor: AZA-PEPTIDE EXPOXIDE, Caspase-3
Authors:Ganesan, R, Jelakovic, S, Campbell, A.J, Li, Z.Z, Asgian, J.L, Powers, J.C, Grutter, M.G.
Deposit date:2006-05-22
Release date:2007-05-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Exploring the S4 and S1 Prime Subsite Specificities in Caspase-3 with Aza-Peptide Epoxide Inhibitors
Biochemistry, 45, 2006
2CNL
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BU of 2cnl by Molmil
Crystal structures of caspase-3 in complex with aza-peptide epoxide inhibitors.
Descriptor: AZA-PEPTIDE EPOXIDE, CASPASE-3 SUBUNIT P12, CASPASE-3 SUBUNIT P17
Authors:Ganesan, R, Jelakovic, S, Campbell, A.J, Li, Z.Z, Asgian, J.L, Grutter, M.G, Powers, J.C.
Deposit date:2006-05-22
Release date:2007-05-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Exploring the S4 and S1 Prime Subsite Specificities in Caspase-3 with Aza-Peptide Epoxide Inhibitors
Biochemistry, 45, 2006
2CNK
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BU of 2cnk by Molmil
Crystal structures of caspase-3 in complex with aza-peptide epoxide inhibitors.
Descriptor: AZA-PEPTIDE EXPOXIDE, CASPASE-3 P12 SUBUNIT, CASPASE-3 P17 SUBUNIT
Authors:Ganesan, R, Jelakovic, S, Campbell, A.J, Li, Z.Z, Asgian, J.L, Powers, J.C, Grutter, M.G.
Deposit date:2006-05-22
Release date:2007-05-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Exploring the S4 and S1 Prime Subsite Specificities in Caspase-3 with Aza-Peptide Epoxide Inhibitors
Biochemistry, 45, 2006
4HQR
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BU of 4hqr by Molmil
Crystal Structure of mutant form of Caspase-7
Descriptor: Ac-Asp-Glu-Val-Asp-Aldehyde, Caspase-7
Authors:Lee, Y, Kang, H.J, Bae, K.-H, Kim, S.J, Chung, S.J.
Deposit date:2012-10-26
Release date:2013-09-11
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural asymmetry of procaspase-7 bound to a specific inhibitor
Acta Crystallogr.,Sect.D, 69, 2013
4HQ0
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BU of 4hq0 by Molmil
Crystal Structure of mutant form of Caspase-7
Descriptor: Caspase-7
Authors:Lee, Y, Kang, H.J, Bae, K.-H, Kim, S.J, Chung, S.J.
Deposit date:2012-10-25
Release date:2013-09-11
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural asymmetry of procaspase-7 bound to a specific inhibitor
Acta Crystallogr.,Sect.D, 69, 2013
4HVA
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BU of 4hva by Molmil
Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6
Descriptor: Caspase-6, N-[(2R)-1-(3-cyanophenyl)-3-hydroxypropan-2-yl]-5-(3,4-dimethoxyphenyl)furan-3-carboxamide, VEID Inhibitor
Authors:Murray, J.M, Steffek, M.
Deposit date:2012-11-05
Release date:2013-03-20
Method:X-RAY DIFFRACTION (2.074 Å)
Cite:Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6.
Plos One, 7, 2012
4IYR
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BU of 4iyr by Molmil
Crystal structure of full-length caspase-6 zymogen
Descriptor: Caspase-6
Authors:Cao, Q, Wang, X.-J, Li, L.-F, Su, X.-D.
Deposit date:2013-01-29
Release date:2014-01-15
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.697 Å)
Cite:The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays.
Acta Crystallogr.,Sect.D, 70, 2014
4QUG
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BU of 4qug by Molmil
Caspase-3 M61A
Descriptor: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, ACETATE ION, AZIDE ION, ...
Authors:Cade, C, Swartz, P.D, MacKenzie, S.H, Clark, A.C.
Deposit date:2014-07-10
Release date:2014-11-05
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.917 Å)
Cite:Modifying caspase-3 activity by altering allosteric networks.
Biochemistry, 53, 2014
4QUL
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BU of 4qul by Molmil
Caspase-3 F55W
Descriptor: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, AZIDE ION, Caspase-3
Authors:Cade, C, Swartz, P.D, MacKenzie, S.H, Clark, A.C.
Deposit date:2014-07-10
Release date:2014-11-05
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.898 Å)
Cite:Modifying caspase-3 activity by altering allosteric networks.
Biochemistry, 53, 2014
4JB8
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BU of 4jb8 by Molmil
Caspase-7 in Complex with DARPin C7_16
Descriptor: Caspase-7 subunit p11, Caspase-7 subunit p20, DARPin C7_16
Authors:Fluetsch, A, Seeger, M.A, Gruetter, M.G.
Deposit date:2013-02-19
Release date:2013-08-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Design, construction, and characterization of a second-generation DARPin library with reduced hydrophobicity.
Protein Sci., 22, 2013
4QUD
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BU of 4qud by Molmil
Caspase-3 T140F
Descriptor: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3
Authors:Cade, C, Swartz, P.D, MacKenzie, S.H, Clark, A.C.
Deposit date:2014-07-10
Release date:2014-11-05
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.995 Å)
Cite:Modifying caspase-3 activity by altering allosteric networks.
Biochemistry, 53, 2014
4JJ8
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BU of 4jj8 by Molmil
Caspase-3 specific unnatural amino acid peptides
Descriptor: Caspase Inhibitor, Caspase-7
Authors:Vickers, C.J, Gonzalez-Paez, G.E, Wolan, D.W.
Deposit date:2013-03-07
Release date:2013-06-12
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.937 Å)
Cite:Selective Detection of Caspase-3 versus Caspase-7 Using Activity-Based Probes with Key Unnatural Amino Acids.
Acs Chem.Biol., 8, 2013
4QTY
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BU of 4qty by Molmil
Caspase-3 E190A
Descriptor: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, AZIDE ION, Caspase-3, ...
Authors:Cade, C, Swartz, P.D, MacKenzie, S.H, Clark, A.C.
Deposit date:2014-07-09
Release date:2014-11-05
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.602 Å)
Cite:Modifying caspase-3 activity by altering allosteric networks.
Biochemistry, 53, 2014
4QU5
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BU of 4qu5 by Molmil
Caspase-3 T140V
Descriptor: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3
Authors:Cade, C, Swartz, P.D, MacKenzie, S.H, Clark, A.C.
Deposit date:2014-07-10
Release date:2014-11-05
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.908 Å)
Cite:Modifying caspase-3 activity by altering allosteric networks.
Biochemistry, 53, 2014
4QUI
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BU of 4qui by Molmil
Caspase-3 F128AV266H
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, CHLORIDE ION, ...
Authors:Cade, C, Swartz, P.D, MacKenzie, S.H, Clark, A.C.
Deposit date:2014-07-10
Release date:2014-11-05
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.758 Å)
Cite:Modifying caspase-3 activity by altering allosteric networks.
Biochemistry, 53, 2014
4QUA
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BU of 4qua by Molmil
Caspase-3 Y195F
Descriptor: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3
Authors:Cade, C, Swartz, P.D, MacKenzie, S.H, Clark, A.C.
Deposit date:2014-07-10
Release date:2014-11-05
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.892 Å)
Cite:Modifying caspase-3 activity by altering allosteric networks.
Biochemistry, 53, 2014
4JJE
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BU of 4jje by Molmil
Caspase-3 specific unnatural amino acid peptides
Descriptor: Caspase inhibitor, Caspase-3
Authors:Vickers, C.J, Gonzalez-Paez, G.E, Wolan, D.W.
Deposit date:2013-03-07
Release date:2013-06-12
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.481 Å)
Cite:Selective Detection of Caspase-3 versus Caspase-7 Using Activity-Based Probes with Key Unnatural Amino Acids.
Acs Chem.Biol., 8, 2013
4QUB
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BU of 4qub by Molmil
Caspase-3 K137A
Descriptor: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, AZIDE ION, Caspase-3
Authors:Cade, C, Swartz, P.D, MacKenzie, S.H, Clark, A.C.
Deposit date:2014-07-10
Release date:2014-11-05
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.689 Å)
Cite:Modifying caspase-3 activity by altering allosteric networks.
Biochemistry, 53, 2014

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