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2DKO	Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis Descriptor: Caspase-3, PHQ-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE Authors: Mittl, P.R.E, Ganesan, R, Jelakovic, S, Grutter, M.G. Deposit date: 2006-04-12 Release date: 2006-07-04 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.06 Å) Cite: Extended Substrate Recognition in Caspase-3 Revealed by High Resolution X-ray Structure Analysis J.Mol.Biol., 359, 2006
2CJY	Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis Descriptor: CASPASE-3, PHQ-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE Authors: Ganesan, R, Mittl, P.R.E, Jelakovic, S, Grutter, M.G. Deposit date: 2006-04-09 Release date: 2006-06-27 Last modified: 2017-06-28 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Extended Substrate Recognition in Caspase-3 Revealed by High Resolution X-Ray Structure Analysis J.Mol.Biol., 359, 2006
4EHD	Allosteric Modulation of Caspase-3 through Mutagenesis Descriptor: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 Authors: Walters, J, Schipper, J.L, Swartz, P, Mattos, C, Clark, A.C. Deposit date: 2012-04-02 Release date: 2012-06-06 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (1.581 Å) Cite: Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32, 2012
4EHN	Allosteric Modulation of Caspase-3 through Mutagenesis Descriptor: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 Authors: Walters, J, Schipper, J.L, Swartz, P.D, Mattos, C, Clark, A.C. Deposit date: 2012-04-02 Release date: 2012-06-06 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (1.69 Å) Cite: Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32, 2012
4EHF	Allosteric Modulation of Caspase-3 through Mutagenesis Descriptor: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 Authors: Walters, J, Schipper, J.L, Swartz, P.D, Mattos, C, Clark, A.C. Deposit date: 2012-04-02 Release date: 2012-06-06 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (1.655 Å) Cite: Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32, 2012
4EJF	Allosteric peptides that bind to a caspase zymogen and mediate caspase tetramerization Descriptor: Caspase-6, PHOSPHATE ION, phage-derived peptide 419 Authors: Murray, J.M. Deposit date: 2012-04-06 Release date: 2012-06-20 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.6465 Å) Cite: Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization. Nat.Chem.Biol., 8, 2012
4EHK	Allosteric Modulation of Caspase-3 through Mutagenesis Descriptor: ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR, Caspase-3 Authors: Walters, J, Schipper, J.L, Swartz, P.D, Mattos, C, Clark, A.C. Deposit date: 2012-04-02 Release date: 2012-06-06 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (1.668 Å) Cite: Allosteric modulation of caspase 3 through mutagenesis. Biosci.Rep., 32, 2012
4F6P	Crystal structure of the yeast metacaspase Yca1 C276A mutant Descriptor: 1,1-diphenylethanol, Metacaspase-1 Authors: Wong, A.H, Yan, C.Y, Shi, Y.G. Deposit date: 2012-05-15 Release date: 2013-03-27 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.619 Å) Cite: Crystal structure of the metacaspase Yca1 To be Published
4F6O	Crystal structure of the yeast metacaspase Yca1 Descriptor: 1,1-diphenylethanol, Metacaspase-1 Authors: Wong, A.H, Yan, C.Y, Shi, Y.G. Deposit date: 2012-05-15 Release date: 2012-07-11 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.681 Å) Cite: Crystal structure of the yeast metacaspase Yca1. J.Biol.Chem., 287, 2012
4FEA	Crystal structure of CASPASE-7 in Complex with allosteric inhibitor Descriptor: Caspase-7, chloro{methyl hydrogenato(3-)-kappa~2~N,S [pyridin-2-yl(pyridin-2(1H)-ylidene-kappaN)methyl]carbonodithiohydrazonate}copper Authors: Kabaleeswaran, V. Deposit date: 2012-05-29 Release date: 2012-08-01 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.79 Å) Cite: A class of allosteric caspase inhibitors identified by high-throughput screening. Mol.Cell, 47, 2012
4FXO	Zinc-mediated allosteric inhibiton of caspase-6 Descriptor: Caspase-6, ZINC ION Authors: Velazquez-Delgado, E.M, Hardy, J.A. Deposit date: 2012-07-03 Release date: 2012-08-22 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Zinc-mediated Allosteric Inhibition of Caspase-6. J.Biol.Chem., 287, 2012
4FDL	Crystal structure of Caspase-7 Descriptor: Caspase-7 Authors: Kabaleeswaran, V. Deposit date: 2012-05-28 Release date: 2012-08-01 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.801 Å) Cite: A class of allosteric caspase inhibitors identified by high-throughput screening. Mol.Cell, 47, 2012
4HQR	Crystal Structure of mutant form of Caspase-7 Descriptor: Ac-Asp-Glu-Val-Asp-Aldehyde, Caspase-7 Authors: Lee, Y, Kang, H.J, Bae, K.-H, Kim, S.J, Chung, S.J. Deposit date: 2012-10-26 Release date: 2013-09-11 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural asymmetry of procaspase-7 bound to a specific inhibitor Acta Crystallogr.,Sect.D, 69, 2013
4HQ0	Crystal Structure of mutant form of Caspase-7 Descriptor: Caspase-7 Authors: Lee, Y, Kang, H.J, Bae, K.-H, Kim, S.J, Chung, S.J. Deposit date: 2012-10-25 Release date: 2013-09-11 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural asymmetry of procaspase-7 bound to a specific inhibitor Acta Crystallogr.,Sect.D, 69, 2013
4HVA	Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6 Descriptor: Caspase-6, N-[(2R)-1-(3-cyanophenyl)-3-hydroxypropan-2-yl]-5-(3,4-dimethoxyphenyl)furan-3-carboxamide, VEID Inhibitor Authors: Murray, J.M, Steffek, M. Deposit date: 2012-11-05 Release date: 2013-03-20 Method: X-RAY DIFFRACTION (2.074 Å) Cite: Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. Plos One, 7, 2012
5IAB	Caspase 3 V266D Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ACE-ASP-GLU-VAL-ASK, Caspase-3 Authors: Maciag, J.J, Mackenzie, S.H, Tucker, M.B, Schipper, J.L, Swartz, P.D, Clark, A.C. Deposit date: 2016-02-21 Release date: 2016-10-26 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection. Proc.Natl.Acad.Sci.USA, 113, 2016
5IC6	Crystal structure of caspase-7 DEVE peptide complex Descriptor: Caspase-7 subunit p11, Caspase-7 subunit p20, DEVE peptide Authors: Seaman, J.E, Julien, O, Lee, P.S, Rettenmaier, T.J, Thomsen, N.D, Wells, J.A. Deposit date: 2016-02-22 Release date: 2016-07-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues. Cell Death Differ., 23, 2016
5I9T	Caspase 3 V266C Descriptor: ACE-ASP-GLU-VAL-ASK, ACETATE ION, Caspase-3 Authors: Maciag, J.J, Mackenzie, S.H, Tucker, M.B, Schipper, J.L, Swartz, P.D, Clark, A.C. Deposit date: 2016-02-20 Release date: 2016-10-26 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection. Proc.Natl.Acad.Sci.USA, 113, 2016
5IAR	Caspase 3 V266W Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ACE-ASP-GLU-VAL-ASK, Caspase-3, ... Authors: Maciag, J.J, Mackenzie, S.H, Tucker, M.B, Schipper, J.L, Swartz, P.D, Clark, A.C. Deposit date: 2016-02-21 Release date: 2016-10-26 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection. Proc.Natl.Acad.Sci.USA, 113, 2016
5IAN	Caspase 3 V266N Descriptor: ACE-ASP-GLU-VAL-ASK, Caspase-3, LEU-SER-SER, ... Authors: Maciag, J.J, Mackenzie, S.H, Tucker, M.B, Schipper, J.L, Swartz, P.D, Clark, A.C. Deposit date: 2016-02-21 Release date: 2016-10-26 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection. Proc.Natl.Acad.Sci.USA, 113, 2016
5IBR	Caspase 3 V266K Descriptor: ACE-ASP-GLU-VAL-ASK, Caspase-3 Authors: Maciag, J.J, Mackenzie, S.H, Tucker, M.B, Schipper, J.L, Swartz, P.D, Clark, A.C. Deposit date: 2016-02-22 Release date: 2016-10-26 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection. Proc.Natl.Acad.Sci.USA, 113, 2016
6BFJ	Caspase-3 Mutant - T245D,S249D Descriptor: AZIDE ION, Ac-Asp-Glu-Val-Asp-CMK, Caspase-3 Authors: Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C. Deposit date: 2017-10-26 Release date: 2018-02-21 Last modified: 2018-04-25 Method: X-RAY DIFFRACTION (1.543 Å) Cite: Modifications to a common phosphorylation network provide individualized control in caspases. J. Biol. Chem., 293, 2018
6BG0	Caspase-3 Mutant - D9A,D28A,S150D Descriptor: AC-ASP-GLU-VAL-ASP-CMK, AZIDE ION, Caspase-3, ... Authors: Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C. Deposit date: 2017-10-27 Release date: 2018-02-21 Last modified: 2018-04-25 Method: X-RAY DIFFRACTION (2.125 Å) Cite: Modifications to a common phosphorylation network provide individualized control in caspases. J. Biol. Chem., 293, 2018
5IAJ	Caspase 3 V266L Descriptor: ACE-ASP-GLU-VAL-ASK, Caspase-3, SODIUM ION Authors: Maciag, J.J, Mackenzie, S.H, Tucker, M.B, Schipper, J.L, Swartz, P.D, Clark, A.C. Deposit date: 2016-02-21 Release date: 2016-10-26 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection. Proc.Natl.Acad.Sci.USA, 113, 2016
6BFL	Caspase-3 Mutant- D9A,D28A,T245D Descriptor: AC-ASP-GLU-VAL-ASP-CMK, AZIDE ION, Caspase-3 Authors: Thomas, M.E, Grinshpon, R, Swartz, P.D, Clark, A.C. Deposit date: 2017-10-26 Release date: 2018-02-21 Last modified: 2018-04-25 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Modifications to a common phosphorylation network provide individualized control in caspases. J. Biol. Chem., 293, 2018

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