Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4HVA

Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6

Summary for 4HVA
Entry DOI10.2210/pdb4hva/pdb
Related PRD IDPRD_000960
DescriptorCaspase-6, VEID Inhibitor, N-[(2R)-1-(3-cyanophenyl)-3-hydroxypropan-2-yl]-5-(3,4-dimethoxyphenyl)furan-3-carboxamide, ... (4 entities in total)
Functional Keywordscaspase-6, active, veid, uncompetitive inhibition, ternary complex, caspase, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P55212
Total number of polymer chains4
Total formula weight63327.06
Authors
Murray, J.M.,Steffek, M. (deposition date: 2012-11-05, release date: 2013-03-20)
Primary citationHeise, C.E.,Murray, J.,Augustyn, K.E.,Bravo, B.,Chugha, P.,Cohen, F.,Giannetti, A.M.,Gibbons, P.,Hannoush, R.N.,Hearn, B.R.,Jaishankar, P.,Ly, C.Q.,Shah, K.,Stanger, K.,Steffek, M.,Tang, Y.,Zhao, X.,Lewcock, J.W.,Renslo, A.R.,Flygare, J.,Arkin, M.R.
Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6.
Plos One, 7:e50864-e50864, 2012
Cited by
PubMed: 23227217
DOI: 10.1371/journal.pone.0050864
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.074 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon