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8B9Q
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Molecular structure of Cu(II)-bound amyloid-beta monomer implicated in inhibition of peptide self-assembly in Alzheimer's disease
Descriptor: Amyloid-beta A4 protein, COPPER (II) ION
Authors:Abelein, A, Ciofi-Baffoni, S, Kumar, R, Giachetti, A, Piccioli, M, Biverstal, H.
Deposit date:2022-10-06
Release date:2023-02-08
Last modified:2024-06-05
Method:SOLUTION NMR
Cite:Molecular Structure of Cu(II)-Bound Amyloid-beta Monomer Implicated in Inhibition of Peptide Self-Assembly in Alzheimer's Disease.
Jacs Au, 2, 2022
7B3J
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BU of 7b3j by Molmil
Dynamic complex between all-D-enantiomeric peptide D3 with wild-type amyloid precursor protein 672-726 fragment (amyloid beta 1-55)
Descriptor: D3 all D-enantimeric peptide, Isoform L-APP677 of Amyloid-beta precursor protein
Authors:Bocharov, E.V, Volynsky, P.E, Okhrimenko, I.S, Urban, A.S.
Deposit date:2020-12-01
Release date:2021-01-13
Last modified:2021-12-08
Method:SOLUTION NMR
Cite:All - d - Enantiomeric Peptide D3 Designed for Alzheimer's Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-beta Precursors.
J.Med.Chem., 64, 2021
1NMJ
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BU of 1nmj by Molmil
The Solution Structure of Rat Ab-(1-28) and its Interaction with Zinc: Insights into the Scarity of Amyloid Deposition in Aged Rat Brain
Descriptor: amyloid beta-peptide from Alzheimer's disease amyloid A4 protein homolog
Authors:Huang, J, Yao, Y, Tang, W.X.
Deposit date:2003-01-10
Release date:2003-01-28
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:The solution structure of rat Abeta-(1-28) and its interaction with zinc ion: insights into the scarcity of amyloid deposition in aged rat brain
J.Biol.Inorg.Chem., 9, 2004
2BEG
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BU of 2beg by Molmil
3D Structure of Alzheimer's Abeta(1-42) fibrils
Descriptor: Amyloid beta A4 protein
Authors:Luhrs, T, Ritter, C, Adrian, M, Riek-Loher, D, Bohrmann, B, Dobeli, H, Schubert, D, Riek, R.
Deposit date:2005-10-24
Release date:2005-11-22
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:3D structure of Alzheimer's amyloid-{beta}(1-42) fibrils.
Proc.Natl.Acad.Sci.Usa, 102, 2005
7RTZ
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BU of 7rtz by Molmil
X-ray crystallographic structure of a beta-hairpin peptide derived from amyloid beta 14-40
Descriptor: Amyloid-beta protein 40, CHLORIDE ION
Authors:Samdin, T.D, Kreutzer, A.G, Nowick, J.S.
Deposit date:2021-08-16
Release date:2022-08-31
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A beta-Barrel-Like Tetramer Formed by a beta-Hairpin Derived From A beta
Chem Sci, 2023
3IFN
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BU of 3ifn by Molmil
X-ray structure of amyloid beta peptide:antibody (Abeta1-40:12A11) complex
Descriptor: 12A11 FAB antibody heavy chain, 12A11 FAB antibody light chain, Amyloid beta A4 protein
Authors:Weis, W.I, Feinberg, H, Basi, G.S, Schenk, D.
Deposit date:2009-07-24
Release date:2009-11-17
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease.
J.Biol.Chem., 285, 2010
5KK3
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BU of 5kk3 by Molmil
Atomic Resolution Structure of Monomorphic AB42 Amyloid Fibrils
Descriptor: Beta-amyloid protein 42
Authors:Colvin, M.T, Silvers, R, Zhe Ni, Q, Can, T.V, Sergeyev, I, Rosay, M, Donovan, K.J, Michael, B, Wall, J, Linse, S, Griffin, R.G.
Deposit date:2016-06-20
Release date:2016-07-13
Last modified:2024-05-01
Method:SOLID-STATE NMR
Cite:Atomic Resolution Structure of Monomorphic A beta 42 Amyloid Fibrils.
J.Am.Chem.Soc., 138, 2016
7U4P
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Covalently stabilized triangular trimer composed of Abeta17-36 beta-hairpins
Descriptor: Amyloid-beta 17-36 peptide
Authors:Kreutzer, A.G, Haerianardakani, S, Nowick, J.S.
Deposit date:2022-02-28
Release date:2023-03-15
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.803 Å)
Cite:Antibodies Raised Against an A beta Oligomer Mimic Recognize Pathological Features in Alzheimer's Disease and Associated Amyloid-Disease Brain Tissue.
Acs Cent.Sci., 10, 2024
1Z0Q
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BU of 1z0q by Molmil
Aqueous Solution Structure of the Alzheimer's Disease Abeta Peptide (1-42)
Descriptor: Alzheimer's disease amyloid
Authors:Tomaselli, S, Esposito, V, Vangone, P, van Nuland, N.A, Bonvin, A.M, Guerrini, R, Tancredi, T, Temussi, P.A, Picone, D.
Deposit date:2005-03-02
Release date:2006-05-23
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:The alpha-to-beta Conformational Transition of Alzheimer's Abeta-(1-42) Peptide in Aqueous Media is Reversible: A Step by Step Conformational Analysis Suggests the Location of beta Conformation Seeding
Chembiochem, 7, 2006
6RHY
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BU of 6rhy by Molmil
Structure of pore-forming amyloid-beta tetramers
Descriptor: Amyloid beta A4 protein
Authors:Bardiaux, B, Ciudad, S, Carulla, N.
Deposit date:2019-04-23
Release date:2019-09-25
Last modified:2024-06-19
Method:SOLUTION NMR
Cite:A beta (1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage.
Nat Commun, 11, 2020
7Q4M
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BU of 7q4m by Molmil
Type II beta-amyloid 42 Filaments from Human Brain
Descriptor: Amyloid-beta precursor protein, UNKNOWN ATOM OR ION
Authors:Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M.
Deposit date:2021-11-01
Release date:2021-11-24
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Cryo-EM structures of amyloid-beta 42 filaments from human brains.
Science, 375, 2022
7Q4B
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Type I beta-amyloid 42 Filaments from Human Brain
Descriptor: Amyloid-beta precursor protein, UNKNOWN ATOM OR ION
Authors:Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M.
Deposit date:2021-10-30
Release date:2021-11-24
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Cryo-EM structures of amyloid-beta 42 filaments from human brains.
Science, 375, 2022
1HZ3
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BU of 1hz3 by Molmil
ALZHEIMER'S DISEASE AMYLOID-BETA PEPTIDE (RESIDUES 10-35)
Descriptor: A-BETA AMYLOID
Authors:Zhang, S, Iwata, K, Lachenmann, M.J, Peng, J.W, Li, S, Stimson, E.R, Lu, Y, Felix, A.M, Maggio, J.E, Lee, J.P.
Deposit date:2001-01-23
Release date:2001-01-31
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:The Alzheimer's peptide a beta adopts a collapsed coil structure in water.
J.Struct.Biol., 130, 2000
2LLM
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BU of 2llm by Molmil
Structure of amyloid precursor protein's transmembrane domain
Descriptor: Amyloid beta A4 protein
Authors:Nadezhdin, K.D, Bocharova, O.V, Bocharov, E.V, Arseniev, A.S.
Deposit date:2011-11-15
Release date:2012-06-20
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structural and dynamic study of the transmembrane domain of the amyloid precursor protein.
Acta Naturae, 3, 2011
2LMP
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BU of 2lmp by Molmil
Structural Model for a 40-residue Beta-Amyloid Fibril with Three-Fold Symmetry, Positive Stagger
Descriptor: Beta-amyloid protein 40
Authors:Tycko, R, Paravastu, A.
Deposit date:2011-12-08
Release date:2011-12-28
Last modified:2024-05-01
Method:SOLID-STATE NMR
Cite:Molecular structural basis for polymorphism in Alzheimer's beta-amyloid fibrils
Proc.Natl.Acad.Sci.USA, 105, 2008
1IYT
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BU of 1iyt by Molmil
Solution structure of the Alzheimer's disease amyloid beta-peptide (1-42)
Descriptor: Alzheimer's disease amyloid
Authors:Crescenzi, O, Tomaselli, S, Guerrini, R, Salvadori, S, D'Ursi, A.M, Temussi, P.A, Picone, D.
Deposit date:2002-09-06
Release date:2003-02-11
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Solution structure of the Alzheimer amyloid beta-peptide (1-42) in an apolar microenvironment. Similarity with a virus fusion domain.
EUR.J.BIOCHEM., 269, 2002
8H8Q
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BU of 8h8q by Molmil
Fab-amyloid beta fragment complex at neutral pH
Descriptor: CHLORIDE ION, Fab, GLN-LYS-CYS-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-CYS-GLY, ...
Authors:Kita, A, Irie, K, Irie, Y, Matsushima, Y, Miki, K.
Deposit date:2022-10-24
Release date:2023-10-25
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Fab-amyloid beta fragment complex at neutral pH
To Be Published
8I4O
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BU of 8i4o by Molmil
Design of a split green fluorescent protein for sensing and tracking an beta-amyloid
Descriptor: Beta-amyloid, Split Green flourescent protein
Authors:Taegeun, Y, Jinsu, L, Jungmin, Y, Jungmin, C, Wondo, H, Song, J.J, Haksung, K.
Deposit date:2023-01-20
Release date:2023-11-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Engineering of a Fluorescent Protein for a Sensing of an Intrinsically Disordered Protein through Transition in the Chromophore State.
Jacs Au, 3, 2023
7B3K
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BU of 7b3k by Molmil
Dynamic complex between all-D-enantiomeric peptide D3 with L723P mutant of amyloid precursor protein (APP) 672-726 fragment (amyloid beta 1-55)
Descriptor: D3 all D-enantimeric peptide, Isoform L-APP677 of Amyloid-beta precursor protein
Authors:Bocharov, E.V, Volynsky, P.E, Okhrimenko, I.S, Urban, A.S.
Deposit date:2020-12-01
Release date:2021-01-13
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:All - d - Enantiomeric Peptide D3 Designed for Alzheimer's Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-beta Precursors.
J.Med.Chem., 64, 2021
5AEF
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BU of 5aef by Molmil
Electron cryo-microscopy of an Abeta(1-42)amyloid fibril
Descriptor: AMYLOID BETA A4 PROTEIN
Authors:Schmidt, M, Rohou, A, Lasker, K, Yadav, J.K, Schiene-Fischer, C, Fandrich, M, Grigorieff, N.
Deposit date:2015-08-29
Release date:2015-10-14
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (5 Å)
Cite:Peptide Dimer Structure in an Abeta(1-42) Fibril Visualized with Cryo-Em
Proc.Natl.Acad.Sci.USA, 112, 2015
7Y8Q
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BU of 7y8q by Molmil
Amyloid-beta assemblage on GM1-containing membranes
Descriptor: Amyloid-beta protein 40
Authors:Yagi-Utsumi, M, Itoh, S.G, Okumura, H, Yanagisawa, K, Kato, K, Nishimura, K.
Deposit date:2022-06-24
Release date:2023-07-05
Last modified:2024-05-15
Method:SOLID-STATE NMR
Cite:The Double-Layered Structure of Amyloid-beta Assemblage on GM1-Containing Membranes Catalytically Promotes Fibrillization.
Acs Chem Neurosci, 14, 2023
7E6P
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BU of 7e6p by Molmil
Fab-amyloid beta fragment complex
Descriptor: 1,2-ETHANEDIOL, Amyloid beta fragment with an intramolecular disulfide bond at positions 17 and 28, DI(HYDROXYETHYL)ETHER, ...
Authors:Kita, A, Irie, K, Irie, Y, Miki, K.
Deposit date:2021-02-23
Release date:2022-01-05
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Characterization of a Conformation-Restricted Amyloid beta Peptide and Immunoreactivity of Its Antibody in Human AD brain.
Acs Chem Neurosci, 12, 2021
6W0O
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Amyloid-beta(1-40) fibril derived from Alzheimer's disease cortical tissue
Descriptor: Amyloid-beta precursor protein
Authors:Ghosh, U, Thurber, K.R, Tycko, R.
Deposit date:2020-03-02
Release date:2021-01-13
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (2.77 Å), SOLID-STATE NMR
Cite:Molecular structure of a prevalent amyloid-beta fibril polymorph from Alzheimer's disease brain tissue.
Proc.Natl.Acad.Sci.USA, 118, 2021
8SEJ
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BU of 8sej by Molmil
Type I beta-amyloid 42 Filaments from Down syndrome
Descriptor: Amyloid-beta protein 42
Authors:Hoq, M.R, Bharath, S.R, Vago, F.S, Jiang, W.
Deposit date:2023-04-10
Release date:2024-04-03
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Cryo-EM structures of amyloid-beta and tau filaments in Down syndrome.
Nat.Struct.Mol.Biol., 31, 2024
8SEK
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BU of 8sek by Molmil
Type IIIa beta-amyloid 40 Filaments from Down syndrome
Descriptor: Type IIIb beta-amyloid 40 Filament
Authors:Hoq, M.R, Vago, F.S, Bharath, S.R, Jiang, W.
Deposit date:2023-04-10
Release date:2024-04-03
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structures of amyloid-beta and tau filaments in Down syndrome.
Nat.Struct.Mol.Biol., 31, 2024

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數據於2024-09-18公開中

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