7U4P

Covalently stabilized triangular trimer composed of Abeta17-36 beta-hairpins

This is a non-PDB format compatible entry.

Summary for 7U4P

• Entry DOI: 10.2210/pdb7u4p/pdb
• Descriptor: Amyloid-beta 17-36 peptide (2 entities in total)
• Functional Keywords: abeta oligomer, beta-hairpin, trimer, dodecamer, alzheimer's disease, de novo protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 6643.88

Authors

Kreutzer, A.G.,Haerianardakani, S.,Nowick, J.S. (deposition date: 2022-02-28, release date: 2023-03-15, Last modification date: 2024-03-27)

• Primary citation: Kreutzer, A.G.,Parrocha, C.M.T.,Haerianardakani, S.,Guaglianone, G.,Nguyen, J.T.,Diab, M.N.,Yong, W.,Perez-Rosendahl, M.,Head, E.,Nowick, J.S.; Antibodies Raised Against an A beta Oligomer Mimic Recognize Pathological Features in Alzheimer's Disease and Associated Amyloid-Disease Brain Tissue.; Acs Cent.Sci., 10:104-121, 2024; PubMed: 38292607; DOI: 10.1021/acscentsci.3c00592

Experimental method

X-RAY DIFFRACTION (1.803 Å)