6P8T
| Acinetobacter baumannii tRNA synthetase in complex with compound 1 | 分子名称: | MAGNESIUM ION, N-benzyl-2-(cyclohex-1-en-1-yl)ethan-1-amine, Phenylalanine--tRNA ligase alpha subunit, ... | 著者 | Kahne, D, Baidin, V, Owens, T.W. | 登録日 | 2019-06-07 | 公開日 | 2020-11-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase. J.Am.Chem.Soc., 143, 2021
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5MGV
| Kinetic and Structural Changes in HsmtPheRS, Induced by Pathogenic Mutations in Human FARS2 | 分子名称: | Phenylalanine--tRNA ligase, mitochondrial | 著者 | Kartvelishvili, E, Tworowski, D, Vernon, H, Chrzanowska-Lightowlers, Z, Moor, N, Wang, J, Wong, L.-J, Safro, M. | 登録日 | 2016-11-22 | 公開日 | 2017-05-03 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Kinetic and structural changes in HsmtPheRS, induced by pathogenic mutations in human FARS2. Protein Sci., 26, 2017
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1EIY
| THE CRYSTAL STRUCTURE OF PHENYLALANYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH COGNATE TRNAPHE | 分子名称: | PHENYLALANYL-TRNA SYNTHETASE, TRNA(PHE) | 著者 | Goldgur, Y, Mosyak, L, Reshetnikova, L, Ankilova, V, Safro, M. | 登録日 | 2000-02-29 | 公開日 | 2000-03-06 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | The crystal structure of phenylalanyl-tRNA synthetase from thermus thermophilus complexed with cognate tRNAPhe. Structure, 5, 1997
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3PCO
| crystal structure of E. coli phenylalanine-tRNA synthetase complexed with phenylalanine and AMP | 分子名称: | ADENOSINE MONOPHOSPHATE, PHENYLALANINE, Phenylalanyl-tRNA synthetase, ... | 著者 | Mermershtain, I, Finarov, I, Klipcan, L, Kessler, N, Rozenberg, H, Safro, M.G. | 登録日 | 2010-10-21 | 公開日 | 2011-03-02 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.02 Å) | 主引用文献 | Idiosyncrasy and identity in the prokaryotic phe-system: crystal structure of E. coli phenylalanyl-tRNA synthetase complexed with phenylalanine and AMP. Protein Sci., 20, 2011
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8P8X
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2IY5
| PHENYLALANYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS complexed with tRNA and a phenylalanyl-adenylate analog | 分子名称: | ADENOSINE-5'-[PHENYLALANINOL-PHOSPHATE], MAGNESIUM ION, PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN, ... | 著者 | Moor, N, Kotik-Kogan, O, Tworowski, D, Sukhanova, M, Safro, M. | 登録日 | 2006-07-12 | 公開日 | 2006-09-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | The crystal structure of the ternary complex of phenylalanyl-tRNA synthetase with tRNAPhe and a phenylalanyl-adenylate analogue reveals a conformational switch of the CCA end. Biochemistry, 45, 2006
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3CMQ
| Crystal structure of human mitochondrial phenylalanine tRNA synthetase | 分子名称: | ADENOSINE-5'-[PHENYLALANINYL-PHOSPHATE], MAGNESIUM ION, Phenylalanyl-tRNA synthetase, ... | 著者 | Klipcan, L, Levin, I.L, Kessler, N, Moor, N, Finarov, I, Safro, M. | 登録日 | 2008-03-24 | 公開日 | 2008-07-01 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The tRNA-Induced Conformational Activation of Human Mitochondrial Phenylalanyl-tRNA Synthetase. Structure, 16, 2008
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7N8Y
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4TVA
| Universal Pathway for Post-Transfer Editing Reactions: Insight from Crystal structure of TthPheRS with Puromycine | 分子名称: | PHENYLALANINE, PUROMYCIN, Phenylalanine--tRNA ligase alpha subunit, ... | 著者 | Safro, M, Klipcan, L, Tworowski, D, Peretz, M. | 登録日 | 2014-06-26 | 公開日 | 2015-03-18 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.597 Å) | 主引用文献 | Universal pathway for posttransfer editing reactions: Insights from the crystal structure of TtPheRS with puromycin. Proc.Natl.Acad.Sci.USA, 112, 2015
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1JJC
| Crystal structure at 2.6A resolution of phenylalanyl-tRNA synthetase complexed with phenylalanyl-adenylate in the presence of manganese | 分子名称: | ADENOSINE-5'-[PHENYLALANINYL-PHOSPHATE], MANGANESE (II) ION, PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN, ... | 著者 | Safro, M.G, Fishman, R, Moor, N, Ankilova, V. | 登録日 | 2001-07-04 | 公開日 | 2001-11-02 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure at 2.6 A resolution of phenylalanyl-tRNA synthetase complexed with phenylalanyl-adenylate in the presence of manganese. Acta Crystallogr.,Sect.D, 57, 2001
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1PYS
| PHENYLALANYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS | 分子名称: | MAGNESIUM ION, PHENYLALANYL-TRNA SYNTHETASE | 著者 | Safro, M, Mosyak, L, Goldgur, Y, Reshetnikova, L, Delarue, M. | 登録日 | 1996-11-14 | 公開日 | 1997-11-19 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure of phenylalanyl-tRNA synthetase from Thermus thermophilus. Nat.Struct.Biol., 2, 1995
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2RHS
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2RHQ
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1B70
| PHENYLALANYL TRNA SYNTHETASE COMPLEXED WITH PHENYLALANINE | 分子名称: | MAGNESIUM ION, PHENYLALANINE, PHENYLALANYL-TRNA SYNTHETASE | 著者 | Reshetnikova, L, Moor, N, Lavrik, O, Vassylyev, D.G. | 登録日 | 1999-01-26 | 公開日 | 2000-02-09 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structures of phenylalanyl-tRNA synthetase complexed with phenylalanine and a phenylalanyl-adenylate analogue J.Mol.Biol., 287, 1999
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1B7Y
| PHENYLALANYL TRNA SYNTHETASE COMPLEXED WITH PHENYLALANINYL-ADENYLATE | 分子名称: | ADENOSINE-5'-[PHENYLALANINOL-PHOSPHATE], MAGNESIUM ION, PROTEIN (PHENYLALANYL-TRNA SYNTHETASE) | 著者 | Reshetnikova, L, Moor, N, Lavrik, O, Vassylyev, D.G. | 登録日 | 1999-01-26 | 公開日 | 2000-01-26 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structures of phenylalanyl-tRNA synthetase complexed with phenylalanine and a phenylalanyl-adenylate analogue. J.Mol.Biol., 287, 1999
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3HFV
| Crystal structure of human mitochondrial phenylalanyl-tRNA synthetase complexed with m-tyrosine | 分子名称: | META-TYROSINE, Phenylalanyl-tRNA synthetase, mitochondrial | 著者 | Klipcan, L, Moor, N, Kessler, N, Safro, M.G. | 登録日 | 2009-05-12 | 公開日 | 2009-07-21 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Eukaryotic cytosolic and mitochondrial phenylalanyl-tRNA synthetases catalyze the charging of tRNA with the meta-tyrosine Proc.Natl.Acad.Sci.USA, 106, 2009
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3HFZ
| Crystal structure of Thermus thermophilus Phenylalanyl-tRNA synthetase complexed with m-tyrosine | 分子名称: | META-TYROSINE, Phenylalanyl-tRNA synthetase alpha chain, Phenylalanyl-tRNA synthetase beta chain | 著者 | Klipcan, L, Moor, N, Kessler, N, Safro, M.G. | 登録日 | 2009-05-13 | 公開日 | 2009-07-21 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Eukaryotic cytosolic and mitochondrial phenylalanyl-tRNA synthetases catalyze the charging of tRNA with the meta-tyrosine Proc.Natl.Acad.Sci.USA, 106, 2009
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5MGW
| Kinetic and Structural Changes in HsmtPheRS, Induced by Pathogenic Mutations in Human FARS2 | 分子名称: | PHENYLALANINE, Phenylalanine--tRNA ligase, mitochondrial | 著者 | Kartvelishvili, E, Tworowski, D, Vernon, H, Chrzanowska-Lightowlers, Z, Moor, N, Wang, J, Wong, L.-J, Safro, M. | 登録日 | 2016-11-22 | 公開日 | 2017-05-03 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Kinetic and structural changes in HsmtPheRS, induced by pathogenic mutations in human FARS2. Protein Sci., 26, 2017
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6P26
| Escherichia coli tRNA synthetase in complex with compound 1 | 分子名称: | N-benzyl-2-(cyclohex-1-en-1-yl)ethan-1-amine, Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit | 著者 | Kahne, D, Baidin, V, Owens, T.W. | 登録日 | 2019-05-21 | 公開日 | 2020-11-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.16 Å) | 主引用文献 | Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase. J.Am.Chem.Soc., 143, 2021
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5MGU
| Kinetic and Structural Changes in HsmtPheRS, Induced by Pathogenic Mutations in Human FARS2 | 分子名称: | PHENYLALANINE, Phenylalanine--tRNA ligase, mitochondrial | 著者 | Kartvelishvili, E, Tworowski, D, Vernon, H, Chrzanowska-Lightowlers, Z, Moor, N, Wang, J, Wong, L.-J, Safro, M. | 登録日 | 2016-11-22 | 公開日 | 2017-05-03 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Kinetic and structural changes in HsmtPheRS, induced by pathogenic mutations in human FARS2. Protein Sci., 26, 2017
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6P24
| Escherichia coli tRNA synthetase | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | 著者 | Kahne, D, Baidin, V, Owens, T.W. | 登録日 | 2019-05-20 | 公開日 | 2020-11-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase. J.Am.Chem.Soc., 143, 2021
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6OZ5
| Escherichia coli tRNA synthetase in complex with compound 3 | 分子名称: | 1,2-ETHANEDIOL, 2-({[(2S)-1-cyclohexylpropan-2-yl]amino}methyl)phenol, DI(HYDROXYETHYL)ETHER, ... | 著者 | Kahne, D, Baidin, V, Owens, T.W. | 登録日 | 2019-05-15 | 公開日 | 2020-11-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase. J.Am.Chem.Soc., 143, 2021
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3TUP
| Crystal structure of human mitochondrial PheRS complexed with tRNAPhe in the active open state | 分子名称: | Phenylalanyl-tRNA synthetase, mitochondrial, Thermus thermophilus tRNAPhe | 著者 | Safro, M, Klipcan, L, Moor, N, Finarov, I, Kessler, N, Sukhanova, M. | 登録日 | 2011-09-17 | 公開日 | 2011-11-23 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Crystal Structure of Human Mitochondrial PheRS Complexed with tRNA(Phe) in the Active "Open" State. J.Mol.Biol., 415, 2012
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7DAW
| Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase | 分子名称: | Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit, SULFATE ION | 著者 | Xu, M, Zhang, X, Xu, L, Chen, S. | 登録日 | 2020-10-18 | 公開日 | 2021-01-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis . J.Biol.Chem., 2021
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7DB8
| Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase in complex with compound PF-3845 | 分子名称: | N-pyridin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methyl]piperidine-1-carboxamide, Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit, ... | 著者 | Xu, M, Zhang, X, Xu, L, Chen, S. | 登録日 | 2020-10-19 | 公開日 | 2021-01-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis . J.Biol.Chem., 2021
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