2RHS

PheRS from Staphylococcus haemolyticus- rational protein engineering and inhibitor studies

Summary for 2RHS

Entry DOI	10.2210/pdb2rhs/pdb
Related	2RHQ
Descriptor	Phenylalanyl-tRNA synthetase alpha chain, Phenylalanyl-tRNA synthetase beta chain, 1-{3-[(4-pyridin-2-ylpiperazin-1-yl)sulfonyl]phenyl}-3-(1,3-thiazol-2-yl)urea, ... (6 entities in total)
Functional Keywords	heterotetramer, phenylalanine, trna, aminoacyl-trna synthetase, atp-binding, cytoplasm, ligase, magnesium, metal-binding, nucleotide-binding, protein biosynthesis, rna-binding, trna-binding
Biological source	Staphylococcus haemolyticus More
Cellular location	Cytoplasm : Q4L5E3 Q4L5E4
Total number of polymer chains	4
Total formula weight	245446.04
Authors	Evdokimov, A.G.,Mekel, M. (deposition date: 2007-10-09, release date: 2007-11-06, Last modification date: 2024-02-21)
Primary citation	Evdokimov, A.G.,Mekel, M.,Hutchings, K.,Narasimhan, L.,Holler, T.,McGrath, T.,Beattie, B.,Fauman, E.,Yan, C.,Heaslet, H.,Walter, R.,Finzel, B.,Ohren, J.,McConnell, P.,Braden, T.,Sun, F.,Spessard, C.,Banotai, C.,Al-Kassim, L.,Ma, W.,Wengender, P.,Kole, D.,Garceau, N.,Toogood, P.,Liu, J. Rational protein engineering in action: the first crystal structure of a phenylalanine tRNA synthetase from Staphylococcus haemolyticus. J.Struct.Biol., 162:152-169, 2008 Cited by PubMed: 18086534 DOI: 10.1016/j.jsb.2007.11.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation