PDB: 336 件ウェブページステータス検索Chemie searchBIRD

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8TQ0	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with (R)-Lipoic Acid 分子名称: DIHYDROLIPOIC ACID, Hdac6 protein, POTASSIUM ION, ... 著者 Watson, P.R, Christianson, D.W. 登録日 2023-08-06 公開日 2023-09-20 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of histone deacetylase 6 complexed with (R)-lipoic acid, an essential cofactor in central carbon metabolism. J.Biol.Chem., 299, 2023
8TOF	Rpd3S bound to an H3K36Cme3 modified nucleosome 分子名称: Chromatin modification-related protein EAF3, DNA (176-MER), Histone H2A, ... 著者 Markert, J.W, Vos, S.M, Farnung, L. 登録日 2023-08-03 公開日 2024-01-17 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structure of the complete Saccharomyces cerevisiae Rpd3S-nucleosome complex. Nat Commun, 14, 2023
8SZU	Structure of Kdac1-Citarinostat complex from Acinetobacter baumannii 分子名称: Citarinostat, Histone deacetylase domain-containing protein, POTASSIUM ION, ... 著者 Watson, P.R, Christianson, D.W. 登録日 2023-05-30 公開日 2023-09-06 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structure and Function of Kdac1, a Class II Deacetylase from the Multidrug-Resistant Pathogen Acinetobacter baumannii . Biochemistry, 62, 2023
8SZT	Structure of Kdac1 from Acinetobacter baumannii 分子名称: CHLORIDE ION, Histone deacetylase domain-containing protein, POTASSIUM ION, ... 著者 Watson, P.R, Christianson, D.W. 登録日 2023-05-30 公開日 2023-09-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure and Function of Kdac1, a Class II Deacetylase from the Multidrug-Resistant Pathogen Acinetobacter baumannii . Biochemistry, 62, 2023
8KD7	Rpd3S in complex with nucleosome with H3K36MLA modification and 167bp DNA 分子名称: 167bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... 著者 Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Chang, X, Chao, W.C.H, He, J. 登録日 2023-08-09 公開日 2023-09-13 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3.09 Å) 主引用文献 Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
8KD6	Rpd3S in complex with nucleosome with H3K36MLA modification and 187bp DNA, class3 分子名称: 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... 著者 Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J. 登録日 2023-08-09 公開日 2023-09-13 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3.07 Å) 主引用文献 Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
8KD5	Rpd3S in complex with nucleosome with H3K36MLA modification and 187bp DNA, class2 分子名称: 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... 著者 Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Chang, X, Chao, W.C.H, He, J. 登録日 2023-08-09 公開日 2023-09-13 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
8KD4	Rpd3S in complex with nucleosome with H3K36MLA modification and 187bp DNA, class1 分子名称: 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... 著者 Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J. 登録日 2023-08-09 公開日 2023-09-13 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (2.93 Å) 主引用文献 Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
8KD3	Rpd3S in complex with nucleosome with H3K36MLA modification, H3K9Q mutation and 187bp DNA 分子名称: 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... 著者 Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J. 登録日 2023-08-09 公開日 2023-09-13 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
8KD2	Rpd3S in complex with 187bp nucleosome 分子名称: 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... 著者 Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J. 登録日 2023-08-09 公開日 2023-09-13 最終更新日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3.02 Å) 主引用文献 Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
8KC7	Rpd3S histone deacetylase complex 分子名称: Chromatin modification-related protein EAF3, Histone deacetylase RPD3, Transcriptional regulatory protein RCO1, ... 著者 Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J. 登録日 2023-08-06 公開日 2023-09-13 最終更新日 2023-10-18 実験手法 ELECTRON MICROSCOPY (3.46 Å) 主引用文献 Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
8JHO	Cryo-EM structure of the histone deacetylase complex Rpd3S in complex with di-nucleosome 分子名称: Chromatin modification-related protein EAF3, Di-nucleosome template foward, Di-nucleosome template reverse, ... 著者 Wang, H. 登録日 2023-05-25 公開日 2023-09-27 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (7.6 Å) 主引用文献 Structure of histone deacetylase complex Rpd3S bound to nucleosome. Nat.Struct.Mol.Biol., 30, 2023
8IHT	Rpd3S bound to the nucleosome 分子名称: CALCIUM ION, Chromatin modification-related protein EAF3, DNA (164-MER), ... 著者 Zhang, Y, Gang, C. 登録日 2023-02-23 公開日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.72 Å) 主引用文献 Structural basis for nucleosome binding and catalysis by the yeast Rpd3S/HDAC holoenzyme. Cell Res., 33, 2023
8IHN	Cryo-EM structure of the Rpd3S core complex 分子名称: CALCIUM ION, Chromatin modification-related protein EAF3, Histone H3, ... 著者 Zhang, Y, Gang, C. 登録日 2023-02-23 公開日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.37 Å) 主引用文献 Structural basis for nucleosome binding and catalysis by the yeast Rpd3S/HDAC holoenzyme. Cell Res., 33, 2023
8IFG	Cryo-EM structure of the Clr6S (Clr6-HDAC) complex from S. pombe 分子名称: Chromatin modification-related protein eaf3, Cph1, Cph2, ... 著者 Zhang, H.Q, Wang, X, Wang, Y.N, Liu, S.M, Zhang, Y, Xu, K, Ji, L.T, Kornberg, R.D. 登録日 2023-02-17 公開日 2024-01-03 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Class I histone deacetylase complex: Structure and functional correlates. Proc Natl Acad Sci U S A, 120, 2023
8I03	Cryo-EM structure of the SIN3L complex from S. pombe 分子名称: Chromatin modification-related protein png2, Histone deacetylase clr6, POTASSIUM ION, ... 著者 Wang, C, Guo, Z, Zhan, X. 登録日 2023-01-10 公開日 2023-05-03 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Two assembly modes for SIN3 histone deacetylase complexes. Cell Discov, 9, 2023
8I02	Cryo-EM structure of the SIN3S complex from S. pombe 分子名称: Chromatin modification-related protein eaf3, Cph1, Histone deacetylase clr6, ... 著者 Wang, C, Guo, Z, Zhan, X. 登録日 2023-01-10 公開日 2023-05-03 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Two assembly modes for SIN3 histone deacetylase complexes. Cell Discov, 9, 2023
8HY0	Composite cryo-EM structure of the histone deacetylase complex Rpd3S in complex with nucleosome 分子名称: Chromatin modification-related protein EAF3, DNA (352-MER), Histone H2A, ... 著者 Cui, H, Wang, H. 登録日 2023-01-05 公開日 2023-09-27 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structure of histone deacetylase complex Rpd3S bound to nucleosome. Nat.Struct.Mol.Biol., 30, 2023
8HXY	Cryo-EM structure of the histone deacetylase complex Rpd3S in complex with nucleosome 分子名称: Chromatin modification-related protein EAF3, DNA (352-MER), Histone H2A, ... 著者 Cui, H, Wang, H. 登録日 2023-01-05 公開日 2023-09-27 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structure of histone deacetylase complex Rpd3S bound to nucleosome. Nat.Struct.Mol.Biol., 30, 2023
8HXX	Cryo-EM structure of the histone deacetylase complex Rpd3S 分子名称: Chromatin modification-related protein EAF3, Histone H3, Histone deacetylase RPD3, ... 著者 Cui, H, Wang, H. 登録日 2023-01-05 公開日 2023-09-27 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structure of histone deacetylase complex Rpd3S bound to nucleosome. Nat.Struct.Mol.Biol., 30, 2023
8HPO	Cryo-EM structure of a SIN3/HDAC complex from budding yeast 分子名称: Histone deacetylase RPD3, PHOSPHOTHREONINE, POTASSIUM ION, ... 著者 Guo, Z, Zhan, X, Wang, C. 登録日 2022-12-12 公開日 2023-05-03 最終更新日 2023-07-05 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Structure of a SIN3-HDAC complex from budding yeast. Nat.Struct.Mol.Biol., 30, 2023
8GD4	Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with DMFO Inhibitor 6 分子名称: 2-(benzylamino)-N'-(difluoroacetyl)pyrimidine-5-carbohydrazide, Hdac6 protein, POTASSIUM ION, ... 著者 Watson, P.R, Craigin, A.D, Christianson, D.W. 登録日 2023-03-03 公開日 2023-10-04 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Difluoromethyl-1,3,4-oxadiazoles Are Selective, Mechanism-Based, and Essentially Irreversible Inhibitors of Histone Deacetylase 6 . J.Med.Chem., 66, 2023
8GA8	Structure of the yeast (HDAC) Rpd3L complex 分子名称: Histone deacetylase RPD3, Transcriptional regulatory protein DEP1, Transcriptional regulatory protein PHO23, ... 著者 Patel, A.B, Radhakrishnan, I, He, Y. 登録日 2023-02-22 公開日 2023-07-12 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Cryo-EM structure of the Saccharomyces cerevisiae Rpd3L histone deacetylase complex. Nat Commun, 14, 2023
8G20	Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with inhibitor Mz327 分子名称: 1,2-ETHANEDIOL, 4-[(N-butylpentanamido)methyl]-N-hydroxybenzamide, ETHANOL, ... 著者 Tararina, M.A, Christianson, D.W. 登録日 2023-02-03 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.766 Å) 主引用文献 Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation. J.Med.Chem., 66, 2023
8G1Z	Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with inhibitor Mz317 分子名称: 1,2-ETHANEDIOL, 4-(acetamidomethyl)-N-hydroxybenzamide, Hdac6 protein, ... 著者 Tararina, M.A, Christianson, D.W. 登録日 2023-02-03 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation. J.Med.Chem., 66, 2023

 

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