8TQ0
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with (R)-Lipoic Acid
Summary for 8TQ0
| Entry DOI | 10.2210/pdb8tq0/pdb |
| Descriptor | Hdac6 protein, DIHYDROLIPOIC ACID, ZINC ION, ... (5 entities in total) |
| Functional Keywords | hydrolase, histone deacetylase, inhibitor, metallohydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
| Biological source | Danio rerio (zebrafish) |
| Total number of polymer chains | 2 |
| Total formula weight | 81274.86 |
| Authors | Watson, P.R.,Christianson, D.W. (deposition date: 2023-08-06, release date: 2023-09-20, Last modification date: 2024-04-03) |
| Primary citation | Watson, P.R.,Stollmaier, J.G.,Christianson, D.W. Crystal structure of histone deacetylase 6 complexed with (R)-lipoic acid, an essential cofactor in central carbon metabolism. J.Biol.Chem., 299:105228-105228, 2023 Cited by PubMed: 37703993DOI: 10.1016/j.jbc.2023.105228 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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