PDB: 117 件ウェブページステータス検索Chemie searchBIRD

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7MHT	CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI/DNA COMPLEX 分子名称: 5'-D(P*CP*CP*AP*TP*GP*AP*GP*CP*TP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3', CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI, ... 著者 O'Gara, M, Horton, J.R, Roberts, R.J, Cheng, X. 登録日 1998-08-05 公開日 1998-11-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.87 Å) 主引用文献 Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base. Nat.Struct.Biol., 5, 1998
10MH	TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH ADOHCY AND HEMIMETHYLATED DNA CONTAINING 5,6-DIHYDRO-5-AZACYTOSINE AT THE TARGET 分子名称: DNA (5'-D(P*CP*CP*AP*TP*GP*(5CM)P*GP*CP*TP*GP*AP*C)-3'), DNA (5'-D(P*GP*TP*CP*AP*GP*5NCP*GP*CP*AP*TP*GP*G)-3'), PROTEIN (CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI), ... 著者 Sheikhnejad, G, Brank, A, Christman, J.K, Goddard, A, Alvarez, E, Ford Junior, H, Marquez, V.E, Marasco, C.J, Sufrin, J.R, O'Gara, M, Cheng, X. 登録日 1998-08-10 公開日 1999-02-09 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine. J.Mol.Biol., 285, 1999
1SVU	Structure of the Q237W mutant of HhaI DNA methyltransferase: an insight into protein-protein interactions 分子名称: Modification methylase HhaI, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... 著者 Dong, A, Zhou, L, Zhang, X, Stickel, S, Roberts, R.J, Cheng, X. 登録日 2004-03-30 公開日 2004-06-29 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.66 Å) 主引用文献 Structure of the Q237W mutant of HhaI DNA methyltransferase: an insight into protein-protein interactions Biol.Chem., 385, 2004
3G7U	Crystal structure of putative DNA modification methyltransferase encoded within prophage Cp-933R (E.coli) 分子名称: CHLORIDE ION, Cytosine-specific methyltransferase, GLYCEROL 著者 Patskovsky, Y, Ramagopal, U.A, Toro, R, Gilmore, M, Iizuka, M, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) 登録日 2009-02-10 公開日 2009-02-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Crystal Structure of DNA Modification Methyltransferase Encoded within Prophage Cp-933R (E.coli) To be Published
5CIY	Structural basis of the recognition of H3K36me3 by DNMT3B PWWP domain 分子名称: DNA (5'-D(P*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3'), DNA (5'-D(P*GP*TP*CP*AP*GP*(3DR)P*GP*CP*AP*TP*GP*G)-3'), Modification methylase HhaI, ... 著者 Rondelet, G, DAL MASO, T, Willems, L, Wouters, J. 登録日 2015-07-13 公開日 2016-03-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.594 Å) 主引用文献 Structural basis for recognition of histone H3K36me3 nucleosome by human de novo DNA methyltransferases 3A and 3B. J.Struct.Biol., 194, 2016
8MHT	CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI/DNA COMPLEX 分子名称: 5'-D(P*CP*CP*AP*TP*GP*UP*GP*CP*TP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3', CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI, ... 著者 O'Gara, M, Horton, J.R, Roberts, R.J, Cheng, X. 登録日 1998-08-06 公開日 1998-11-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.76 Å) 主引用文献 Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base. Nat.Struct.Biol., 5, 1998
2QRV	Structure of Dnmt3a-Dnmt3L C-terminal domain complex 分子名称: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE 著者 Jia, D, Cheng, X. 登録日 2007-07-29 公開日 2007-12-04 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature, 449, 2007
1SKM	HhaI methyltransferase in complex with DNA containing an abasic south carbocyclic sugar at its target site 分子名称: 5'-D(*T*GP*TP*CP*AP*GP*(HCX)P*GP*CP*AP*TP*GP*G)-3', 5'-D(*TP*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3', Modification methylase HhaI, ... 著者 Horton, J.R, Ratner, G, Banavali, N, Huang, N, Marquez, V.E, MacKerell, A.D, Cheng, X. 登録日 2004-03-05 公開日 2004-08-24 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Caught in the act: visualization of an intermediate in the DNA base-flipping pathway induced by HhaI methyltransferase Nucleic Acids Res., 32, 2004
5LOD	Crystal structure of HhaI DNA methyltransferase in APO form 分子名称: Modification methylase HhaI, SULFATE ION 著者 Rondelet, G, Wouters, J. 登録日 2016-08-09 公開日 2017-08-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors. Future Med Chem, 9, 2017
5YX2	Crystal structure of DNMT3A-DNMT3L in complex with DNA containing two CpG sites 分子名称: DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, ... 著者 Zhang, Z.M, Song, J. 登録日 2017-12-01 公開日 2018-01-31 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.653 Å) 主引用文献 Structural basis for DNMT3A-mediated de novo DNA methylation. Nature, 554, 2018
5MHT	TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH HEMIMETHYLATED DNA AND ADOHCY 分子名称: DNA (5'-D(*CP*CP*AP*TP*GP*(5CM)P*GP*CP*TP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3'), PROTEIN (HHAI METHYLTRANSFERASE), ... 著者 Cheng, X. 登録日 1996-10-22 公開日 1997-07-23 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 A structural basis for the preferential binding of hemimethylated DNA by HhaI DNA methyltransferase. J.Mol.Biol., 263, 1996
3UBT	Crystal Structure of C71S Mutant of DNA Cytosine-5 Methyltransferase M.HaeIII Bound to DNA 分子名称: 5'-D(*TP*GP*GP*CP*CP*A)-3', ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... 著者 Verdine, G.L, Didovyk, A. 登録日 2011-10-24 公開日 2012-10-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.502 Å) 主引用文献 Structural origins of DNA target selection and nucleobase extrusion by a DNA Cytosine methyltransferase. J.Biol.Chem., 287, 2012
6FDF	Crystal structure of S. pombe Dnmt2 methyltransferase 分子名称: GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, tRNA (cytosine(38)-C(5))-methyltransferase 著者 Johannsson, S, Neumann, P, Ficner, R. 登録日 2017-12-22 公開日 2018-06-20 実験手法 X-RAY DIFFRACTION (1.697 Å) 主引用文献 Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine. Sci Rep, 8, 2018
6F57	Crystal structure of DNMT3A-DNMT3L in complex with single CpG-containing DNA 分子名称: DNA (5'-D(*AP*GP*AP*GP*CP*GP*CP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*GP*ZP*GP*CP*TP*CP*T)-3'), DNA (cytosine-5)-methyltransferase 3-like, ... 著者 Zhang, Z.M, Song, J. 登録日 2017-12-01 公開日 2018-01-31 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.098 Å) 主引用文献 Structural basis for DNMT3A-mediated de novo DNA methylation. Nature, 554, 2018
4DKJ	CpG specific methyltransferase in complex with target DNA 分子名称: Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(C37)P*GP*CP*TP*GP*AP*A)-3'), DNA (5'-D(*GP*TP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*TP*G)-3'), ... 著者 Wojciechowski, M, Czapinska, H, Bochtler, M. 登録日 2012-02-03 公開日 2012-12-05 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 CpG underrepresentation and the bacterial CpG-specific DNA methyltransferase M.MpeI. Proc.Natl.Acad.Sci.USA, 110, 2013
6BRR	Crystal structure of DNMT3A (R836A)-DNMT3L in complex with DNA containing two CpG sites 分子名称: DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, ... 著者 Zhang, Z.M, Song, J. 登録日 2017-11-30 公開日 2018-01-31 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.97 Å) 主引用文献 Structural basis for DNMT3A-mediated de novo DNA methylation. Nature, 554, 2018
1HMY	CRYSTAL STRUCTURE OF THE HHAI DNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYL-L-METHIONINE 分子名称: HaeIII METHYLTRANSFERASE, S-ADENOSYLMETHIONINE 著者 Cheng, X. 登録日 1993-08-05 公開日 1993-10-31 最終更新日 2012-02-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine. Cell(Cambridge,Mass.), 74, 1993
1DCT	DNA (CYTOSINE-5) METHYLASE FROM HAEIII COVALENTLY BOUND TO DNA 分子名称: CALCIUM ION, DNA (5'-D(*AP*CP*CP*AP*GP*CP*AP*GP*GP*(C49)P*CP*AP*CP*CP*AP*GP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*CP*TP*GP*GP*TP*GP*GP*(C5M)P*CP*TP*GP*CP*TP*GP*G)-3'), ... 著者 Reinisch, K.M, Chen, L, Verdine, G.L, Lipscomb, W.N. 登録日 1995-05-17 公開日 1995-09-15 最終更新日 2019-11-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The crystal structure of HaeIII methyltransferase convalently complexed to DNA: an extrahelical cytosine and rearranged base pairing. Cell(Cambridge,Mass.), 82, 1995
4MHT	TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH NATIVE DNA AND ADOHCY 分子名称: DNA (5'-D(*GP*AP*TP*AP*GP*(5CM)P*GP*CP*TP*AP*TP*C)-3'), DNA (5'-D(*TP*GP*AP*TP*AP*GP*(5CM)P*GP*CP*TP*AP*TP*C)-3'), PROTEIN (HHAI METHYLTRANSFERASE (E.C.2.1.1.73)), ... 著者 Cheng, X. 登録日 1996-07-24 公開日 1997-01-27 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Enzymatic C5-cytosine methylation of DNA: mechanistic implications of new crystal structures for HhaL methyltransferase-DNA-AdoHcy complexes. J.Mol.Biol., 261, 1996
7X9D	DNMT3B in complex with harmine 分子名称: 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE, DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3B 著者 Cho, C.-C, Yuan, H.S. 登録日 2022-03-15 公開日 2023-03-15 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 Mechanistic Insights into Harmine-Mediated Inhibition of Human DNA Methyltransferases and Prostate Cancer Cell Growth. Acs Chem.Biol., 18, 2023
2HMY	BINARY COMPLEX OF HHAI METHYLTRANSFERASE WITH ADOMET FORMED IN THE PRESENCE OF A SHORT NONPSECIFIC DNA OLIGONUCLEOTIDE 分子名称: PROTEIN (CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI), S-ADENOSYLMETHIONINE 著者 O'Gara, M, Zhang, X, Roberts, R.J, Cheng, X. 登録日 1999-02-08 公開日 1999-03-19 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Structure of a binary complex of HhaI methyltransferase with S-adenosyl-L-methionine formed in the presence of a short non-specific DNA oligonucleotide. J.Mol.Biol., 287, 1999
2HR1	Ternary structure of WT M.HhaI C5-Cytosine DNA methyltransferase with unmodified DNA and AdoHcy 分子名称: 5'-D(*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3', 5'-D(*TP*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3', Modification methylase HhaI, ... 著者 Shieh, F. 登録日 2006-07-19 公開日 2006-09-19 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 The Role of Arg165 Towards Base Flipping, Base Stabilization and Catalysis in M.HhaI. J.Mol.Biol., 362, 2006
1FJX	STRUCTURE OF TERNARY COMPLEX OF HHAI METHYLTRANSFERASE MUTANT (T250G) IN COMPLEX WITH DNA AND ADOHCY 分子名称: DNA (5'-D(*TP*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3'), HHAI DNA METHYLTRANSFERASE, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Vilkaitis, G, Dong, A, Weinhold, E, Cheng, X, Klimasauskas, S. 登録日 2000-08-08 公開日 2000-12-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Functional roles of the conserved threonine 250 in the target recognition domain of HhaI DNA methyltransferase. J.Biol.Chem., 275, 2000
2I9K	Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA Methyltransferase M.HhaI 分子名称: 5'-D(*T*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3', Modification methylase HhaI, S-ADENOSYL-L-HOMOCYSTEINE 著者 Youngblood, B, Shieh, F.K, De Los Rios, S, Perona, J.J, Reich, N.O. 登録日 2006-09-05 公開日 2006-10-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA Methyltransferase M.HhaI J.Mol.Biol., 362, 2006
1G55	Structure of human DNMT2, an enigmatic DNA methyltransferase homologue 分子名称: BETA-MERCAPTOETHANOL, DNA CYTOSINE METHYLTRANSFERASE DNMT2, GLYCEROL, ... 著者 Dong, A, Yoder, J.A, Zhang, X, Zhou, L, Bestor, T.H, Cheng, X. 登録日 2000-10-30 公開日 2001-01-17 最終更新日 2018-06-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA. Nucleic Acids Res., 29, 2001

 

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