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5YX2

Crystal structure of DNMT3A-DNMT3L in complex with DNA containing two CpG sites

Summary for 5YX2
Entry DOI10.2210/pdb5yx2/pdb
DescriptorDNA (cytosine-5)-methyltransferase 3A, DNA (cytosine-5)-methyltransferase 3-like, DNA (25-MER), ... (6 entities in total)
Functional Keywordsdnmt3a, dnmt3l, dna methylation, transferase-transferase regulator-dna complex, transferase/transferase regulator/dna
Biological sourceHomo sapiens (Human)
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Cellular locationNucleus : Q9Y6K1 Q9UJW3
Total number of polymer chains6
Total formula weight130251.86
Authors
Zhang, Z.M.,Song, J. (deposition date: 2017-12-01, release date: 2018-01-31, Last modification date: 2023-11-22)
Primary citationZhang, Z.M.,Lu, R.,Wang, P.,Yu, Y.,Chen, D.,Gao, L.,Liu, S.,Ji, D.,Rothbart, S.B.,Wang, Y.,Wang, G.G.,Song, J.
Structural basis for DNMT3A-mediated de novo DNA methylation.
Nature, 554:387-391, 2018
Cited by
PubMed: 29414941
DOI: 10.1038/nature25477
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.653 Å)
Structure validation

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