5YX2
Crystal structure of DNMT3A-DNMT3L in complex with DNA containing two CpG sites
Summary for 5YX2
Entry DOI | 10.2210/pdb5yx2/pdb |
Descriptor | DNA (cytosine-5)-methyltransferase 3A, DNA (cytosine-5)-methyltransferase 3-like, DNA (25-MER), ... (6 entities in total) |
Functional Keywords | dnmt3a, dnmt3l, dna methylation, transferase-transferase regulator-dna complex, transferase/transferase regulator/dna |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : Q9Y6K1 Q9UJW3 |
Total number of polymer chains | 6 |
Total formula weight | 130251.86 |
Authors | Zhang, Z.M.,Song, J. (deposition date: 2017-12-01, release date: 2018-01-31, Last modification date: 2023-11-22) |
Primary citation | Zhang, Z.M.,Lu, R.,Wang, P.,Yu, Y.,Chen, D.,Gao, L.,Liu, S.,Ji, D.,Rothbart, S.B.,Wang, Y.,Wang, G.G.,Song, J. Structural basis for DNMT3A-mediated de novo DNA methylation. Nature, 554:387-391, 2018 Cited by PubMed: 29414941DOI: 10.1038/nature25477 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.653 Å) |
Structure validation
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