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4XCR
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Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant I35A
分子名称: Superoxide dismutase [Cu-Zn]
著者Wang, H, Logan, D.T, Danielsson, J, Mu, X, Binolfi, A, Theillet, F, Bekei, B, Lang, L, Wennerstrom, H, Selenko, P, Oliveberg, M.
登録日2014-12-18
公開日2016-01-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.602 Å)
主引用文献Thermodynamics of protein destabilization in live cells.
Proc. Natl. Acad. Sci. U.S.A., 112, 2015
2K4W
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BU of 2k4w by Molmil
The Solution Structure of the Monomeric Copper, Zinc Superoxide Dismutase from Salmonella enterica
分子名称: COPPER (I) ION, Superoxide dismutase [Cu-Zn], ZINC ION
著者Mori, M, Jimenez, B, Piccioli, M, Battistoni, A, Sette, M, Structural Proteomics in Europe (SPINE)
登録日2008-06-20
公開日2008-11-18
最終更新日2021-10-20
実験手法SOLUTION NMR
主引用文献The Solution Structure of the Monomeric Copper, Zinc Superoxide Dismutase from Salmonella enterica: Structural Insights To Understand the Evolution toward the Dimeric Structure.
Biochemistry, 47, 2008
8CCX
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BU of 8ccx by Molmil
Human SOD1 in complex with S-XL6 cross-linker
分子名称: COPPER (II) ION, DIMETHYL SULFOXIDE, SULFATE ION, ...
著者Antonyuk, S.V, Hossain, A, Agar, J.N, Hasnain, S.S.
登録日2023-01-27
公開日2023-12-13
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.665 Å)
主引用文献Evaluating protein cross-linking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS.
Plos Biol., 22, 2024
4MCM
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BU of 4mcm by Molmil
Human SOD1 C57S Mutant, As-isolated
分子名称: SULFATE ION, Superoxide dismutase [Cu-Zn], ZINC ION
著者Sea, K, Sohn, S.H, Durazo, A, Sheng, Y, Shaw, B, Cao, X, Taylor, A.B, Whitson, L.J, Holloway, S.P, Hart, P.J, Cabelli, D.E, Gralla, E.B, Valentine, J.S.
登録日2013-08-21
公開日2014-08-27
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Insights into the role of the unusual disulfide bond in copper-zinc superoxide dismutase.
J.Biol.Chem., 290, 2015
7NXX
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BU of 7nxx by Molmil
Structure of Superoxide Dismutase 1 (SOD1) in complex with nanobody 2 (Nb2).
分子名称: COPPER (II) ION, Superoxide dismutase [Cu-Zn], ZINC ION, ...
著者Gallardo, R, Rousseau, F, Schymkowitz, J, Ulens, C.
登録日2021-03-19
公開日2022-09-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.189 Å)
主引用文献Identification and rational improvement of a nanobody that suppresses aggregation of mutant SOD1
To Be Published
5CU9
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BU of 5cu9 by Molmil
CANDIDA ALBICANS SUPEROXIDE DISMUTASE 5 (SOD5), APO
分子名称: Cell surface Cu-only superoxide dismutase 5, SULFATE ION
著者Waninger-Saroni, J.J, Taylor, A.B, Hart, P.J, Galaleldeen, A.
登録日2015-07-24
公開日2016-07-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献CANDIDA ALBICANS SUPEROXIDE DISMUTASE 5 (SOD5), APO
To Be Published
8GSQ
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Structure based studies reveal an atypical antipsychotic drug candidate - Paliperidone as a potent hSOD1 modulator with implications in ALS treatment.
分子名称: (9~{R})-3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-9-oxidanyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one, GLYCEROL, Superoxide dismutase [Cu-Zn], ...
著者Aouti, S, Padmanabhan, B.
登録日2022-09-06
公開日2023-06-14
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure-based discovery of an antipsychotic drug, paliperidone, as a modulator of human superoxide dismutase 1: a potential therapeutic target in amyotrophic lateral sclerosis.
Acta Crystallogr D Struct Biol, 79, 2023
5IN2
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BU of 5in2 by Molmil
Crystal structure of extra cellular Cu/Zn Superoxide Dismutase from Onchocerca volvulus at 1.5 Angstrom; Insight into novel binding site and new inhibitors
分子名称: AZIDE ION, CHLORIDE ION, COPPER (II) ION, ...
著者Moustafa, A, Betzel, C, Perbandt, M.
登録日2016-03-07
公開日2017-03-29
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Crystal structure of extracellular Cu/Zn Superoxide Dismutase from Onchocerca volvulus at 1.5 Angstrom; Insight into novel binding site and new inhibitors
To Be Published
4FF9
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BU of 4ff9 by Molmil
Crystal Structure of cysteinylated WT SOD1.
分子名称: COPPER (II) ION, CYSTEINE, Superoxide dismutase [Cu-Zn], ...
著者Auclair, J.R, Brodkin, H.R, D'Aquino, J.A, Ringe, D, Petsko, G.A, Agar, J.N.
登録日2012-05-31
公開日2013-09-04
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.5003 Å)
主引用文献Structural consequences of cysteinylation of cu/zn-superoxide dismutase.
Biochemistry, 52, 2013
4L05
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BU of 4l05 by Molmil
Cu/Zn superoxide dismutase from Brucella abortus
分子名称: COPPER (I) ION, COPPER (II) ION, GLYCEROL, ...
著者Shin, D.S, Didonato, M, Pratt, A.J, Bruns, C.K, Cabelli, D.E, Kroll, J.S, Belzer, C.A, Tabatabai, L.B, Tainer, J.A, Getzoff, E.D.
登録日2013-05-30
公開日2013-10-23
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.098 Å)
主引用文献Structural, Functional, and Immunogenic Insights on Cu,Zn Superoxide Dismutase Pathogenic Virulence Factors from Neisseria meningitidis and Brucella abortus.
J.Bacteriol., 197, 2015
2WZ0
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BU of 2wz0 by Molmil
L38V SOD1 mutant complexed with aniline.
分子名称: 2-METHOXY-5-METHYLANILINE, COPPER (II) ION, D-SERINE, ...
著者Antonyuk, S, Strange, R.W, Hasnain, S.S.
登録日2009-11-20
公開日2010-12-08
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Structural Discovery of Small Molecule Binding Sites in Cu-Zn Human Superoxide Dismutase Familial Amyotrophic Lateral Sclerosis Mutants Provides Insights for Lead Optimization.
J.Med.Chem., 53, 2010
2XJL
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BU of 2xjl by Molmil
Monomeric Human Cu,Zn Superoxide dismutase without Cu ligands
分子名称: ACETATE ION, DI(HYDROXYETHYL)ETHER, SODIUM ION, ...
著者Saraboji, K, Leinartaite, L, Nordlund, A, Oliveberg, M, Logan, D.T.
登録日2010-07-07
公開日2010-09-01
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Folding Catalysis by Transient Coordination of Zn2+ to the Cu Ligands of the Als-Associated Enzyme Cu/Zn Superoxide Dismutase 1.
J.Am.Chem.Soc., 132, 2010
7YPP
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BU of 7ypp by Molmil
Structural basis of a superoxide dismutase from a tardigrade, Ramazzottius varieornatus strain YOKOZUNA-1.
分子名称: CALCIUM ION, COPPER (II) ION, Superoxide dismutase [Cu-Zn], ...
著者Sim, K.-S, Fukuda, Y, Inoue, T.
登録日2022-08-04
公開日2023-07-26
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of a superoxide dismutase from a tardigrade: Ramazzottius varieornatus strain YOKOZUNA-1.
Acta Crystallogr.,Sect.F, 79, 2023
7B4O
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BU of 7b4o by Molmil
A Bacteroidetes bacterium CuZn-superoxide dismutase with ZnZn metalation
分子名称: Superoxide dismutase [Cu-Zn], ZINC ION
著者Wright, G.S.A.
登録日2020-12-02
公開日2021-06-02
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.41 Å)
主引用文献Bacterial Evolutionary Precursors of Eukaryotic Copper-Zinc Superoxide Dismutases.
Mol.Biol.Evol., 38, 2021
7YPR
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BU of 7ypr by Molmil
Structural basis of a superoxide dismutase from a tardigrade, Ramazzottius varieornatus strain YOKOZUNA-1.
分子名称: COPPER (II) ION, POTASSIUM ION, Superoxide dismutase [Cu-Zn], ...
著者Sim, K.-S, Fukuda, Y, Inoue, T.
登録日2022-08-04
公開日2023-12-06
実験手法X-RAY DIFFRACTION (2.101 Å)
主引用文献Structure of a superoxide dismutase from a tardigrade: Ramazzottius varieornatus strain YOKOZUNA-1.
Acta Crystallogr.,Sect.F, 79, 2023
7B4P
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BU of 7b4p by Molmil
A Bacteroidetes bacterium CuZn-superoxide dismutase with CuZn metalation
分子名称: COPPER (II) ION, Superoxide dismutase [Cu-Zn], ZINC ION
著者Wright, G.S.A.
登録日2020-12-02
公開日2021-06-02
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Bacterial Evolutionary Precursors of Eukaryotic Copper-Zinc Superoxide Dismutases.
Mol.Biol.Evol., 38, 2021
7FB6
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BU of 7fb6 by Molmil
C57D/C146D mutant of Human Cu, Zn Superoxide Dismutase (SOD1)
分子名称: CHLORIDE ION, COPPER (II) ION, Superoxide dismutase [Cu-Zn], ...
著者Baek, Y, Ha, N.-C.
登録日2021-07-08
公開日2022-10-12
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural analysis of the overoxidized Cu/Zn-superoxide dismutase in ROS-induced ALS filament formation.
Commun Biol, 5, 2022
7FB9
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BU of 7fb9 by Molmil
Crystal Structure of Human Cu, Zn Superoxide Dismutase (SOD1)
分子名称: COPPER (II) ION, Superoxide dismutase [Cu-Zn], ZINC ION
著者Baek, Y, Ha, N.-C.
登録日2021-07-08
公開日2022-10-12
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural analysis of the overoxidized Cu/Zn-superoxide dismutase in ROS-induced ALS filament formation.
Commun Biol, 5, 2022
6DTK
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BU of 6dtk by Molmil
Heterodimers of FALS mutant SOD enzyme
分子名称: COPPER (II) ION, MALONATE ION, Superoxide dismutase C111S/D83S-C111S HETERODIMER, ...
著者Streltsov, V.A, Nuttall, S.D, Ganio, K.E, Roberts, B.
登録日2018-06-17
公開日2019-06-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural characterization of heterodimers of FALS mutant SOD enzyme
To Be Published
5O40
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SOD1 bound to Ebselen
分子名称: N-phenyl-2-selanylbenzamide, SULFATE ION, Superoxide dismutase [Cu-Zn], ...
著者Capper, M.J, Wright, G.S.A, Antonyuk, S.V, Hasnain, S.S.
登録日2017-05-25
公開日2018-06-13
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation.
Nat Commun, 9, 2018
7CJV
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BU of 7cjv by Molmil
Solution structure of monomeric superoxide dismutase 1 with an additional mutation H46W in a dilute environment
分子名称: Monomeric Human Cu,Zn Superoxide dismutase
著者Iwakawa, N, Morimoto, D, Walinda, E, Danielsson, J, Shirakawa, M, Sugase, K.
登録日2020-07-14
公開日2021-05-26
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Transient Diffusive Interactions with a Protein Crowder Affect Aggregation Processes of Superoxide Dismutase 1 beta-Barrel.
J.Phys.Chem.B, 125, 2021
5O3Y
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BU of 5o3y by Molmil
SOD1 bound to Ebsulfur
分子名称: SULFATE ION, Superoxide dismutase [Cu-Zn], ZINC ION, ...
著者Capper, M.J, Wright, G.S.A, Antonyuk, S.V, Hasnain, S.S.
登録日2017-05-25
公開日2018-06-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation.
Nat Commun, 9, 2018
4RVP
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BU of 4rvp by Molmil
Crystal structure of superoxide dismutase from sedum alfredii
分子名称: ZINC ION, superoxide dismutase
著者Qiu, R, Li, C, Zhai, J, Tang, L, Zhang, H, Yuan, M, Hu, X.
登録日2014-11-27
公開日2015-12-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The positive effects of Cd and Cd-Zn relationship in the Zn-related physiological processes involved in growth in the Zn/Cd hyperaccumulator Sedum alfredii
To be Published
8YD3
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BU of 8yd3 by Molmil
Crystal structure of human Cu-Zn Superoxide Dismutase 1 in complex with 1,2,10-Decanetriol
分子名称: (2S)-decane-1,2,10-triol, GLYCEROL, Superoxide dismutase [Cu-Zn], ...
著者Aouti, S, Padmanabhan, B.
登録日2024-02-19
公開日2024-08-21
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Crystal structure of human Cu-Zn Superoxide Dismutase 1 in complex with 1,2,10-Decanetriol
To Be Published
7CJW
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BU of 7cjw by Molmil
Solution structure of monomeric superoxide dismutase 1 with an additional mutation H46W in a crowded environment
分子名称: Monomeric Human Cu,Zn Superoxide dismutase
著者Iwakawa, N, Morimoto, D, Walinda, E, Danielsson, J, Shirakawa, M, Sugase, K.
登録日2020-07-14
公開日2021-05-26
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Transient Diffusive Interactions with a Protein Crowder Affect Aggregation Processes of Superoxide Dismutase 1 beta-Barrel.
J.Phys.Chem.B, 125, 2021

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