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2X1V
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BU of 2x1v by Molmil
Crystal Structure of the activating H-Ras I163F mutant in Costello Syndrome, bound to MG-GDP
分子名称: GTPASE HRAS, GUANOSINE-5'-DIPHOSPHATE
著者Anand, K.
登録日2010-01-04
公開日2010-01-12
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal Structure of the Activating H-Ras I163F Mutant in Costello Syndrome, Bound to Mg-Gdp
To be Published
7NY8
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Affimer K69 - KRAS protein complex
分子名称: Affimer K69, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
著者Turner, A.L, Trinh, C.H, Haza, K.Z, Rao, A, Martin, H.L, Tiede, C, Edwards, T.A, McPherson, M.J, Tomlinson, D.C.
登録日2021-03-21
公開日2021-07-07
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献RAS-inhibiting biologics identify and probe druggable pockets including an SII-alpha 3 allosteric site.
Nat Commun, 12, 2021
1QG4
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BU of 1qg4 by Molmil
CANINE GDP-RAN F72Y MUTANT
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PROTEIN (RAN)
著者Kent, H.M, Moore, M.S, Quimby, B.B, Baker, A.M.E, McCoy, A.J, Murphy, G.A, Corbett, A.H, Stewart, M.
登録日1999-04-20
公開日1999-06-11
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Engineered mutants in the switch II loop of Ran define the contribution made by key residues to the interaction with nuclear transport factor 2 (NTF2) and the role of this interaction in nuclear protein import.
J.Mol.Biol., 289, 1999
2KB0
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BU of 2kb0 by Molmil
Cdc42(T35A)
分子名称: Cell division control protein 42 homolog
著者Adams, P.D, Oswald, R.E, McFeeters, R.
登録日2008-11-18
公開日2009-12-01
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Cdc42(T35A)
To be Published
221P
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BU of 221p by Molmil
THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES
分子名称: H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Krengel, U, Scherer, A, Kabsch, W, Wittinghofer, A, Pai, E.F.
登録日1991-06-06
公開日1994-01-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules.
Cell(Cambridge,Mass.), 62, 1990
1QRA
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BU of 1qra by Molmil
STRUCTURE OF P21RAS IN COMPLEX WITH GTP AT 100 K
分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, TRANSFORMING PROTEIN P21/H-RAS-1
著者Scheidig, A, Burmester, C, Goody, R.S.
登録日1999-06-12
公開日1999-11-05
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins.
Structure Fold.Des., 7, 1999
2A5J
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BU of 2a5j by Molmil
Crystal Structure of Human RAB2B
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-2B
著者Dong, A, Wang, J, Shen, Y, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Bochkarev, A, Park, H.W, Structural Genomics Consortium (SGC)
登録日2005-06-30
公開日2005-07-19
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.501 Å)
主引用文献Crystal structure of human RAB2B
To be Published
5MLB
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BU of 5mlb by Molmil
Crystal structure of human RAS in complex with darpin K27
分子名称: DARPin K27, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
著者Debreczeni, J.E, Guillard, S, Kolasinska-Zwierz, P, Breed, J, Zhang, J, Bery, N, Marwood, R, Tart, J, Overman, R, Stocki, P, Mistry, B, Phillips, C, Rabbitts, T, Jackson, R, Minter, R.
登録日2016-12-06
公開日2017-12-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.22 Å)
主引用文献INhibition of RAS nucleotide exchange by a DARPin: structural characterisation and effects on downstream signalling by active RAS
To Be Published
2LCF
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BU of 2lcf by Molmil
Solution structure of GppNHp-bound H-RasT35S mutant protein
分子名称: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Araki, M, Shima, F, Yoshikawa, Y, Muraoka, S, Ijiri, Y, Nagahara, Y, Shirono, T, Kataoka, T, Tamura, A.
登録日2011-04-28
公開日2011-09-28
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers.
J.Biol.Chem., 286, 2011
3KKQ
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BU of 3kkq by Molmil
Crystal structure of M-Ras P40D in complex with GDP
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein M-Ras
著者Muraoka, S, Shima, F, Liao, J, Ijiri, Y, Matsumoto, K, Ye, M, Inoue, T, Kataoka, T.
登録日2009-11-06
公開日2010-06-16
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Structural basis for conformational dynamics of GTP-bound Ras protein
J.Biol.Chem., 285, 2010
3KKM
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BU of 3kkm by Molmil
Crystal structure of H-Ras T35S in complex with GppNHp
分子名称: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Muraoka, S, Shima, F, Liao, J, Ijiri, Y, Matsumoto, K, Ye, M, Inoue, T, Kataoka, T.
登録日2009-11-06
公開日2010-06-16
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural basis for conformational dynamics of GTP-bound Ras protein
J.Biol.Chem., 285, 2010
3KKP
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BU of 3kkp by Molmil
Crystal structure of M-Ras P40D in complex with GppNHp
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein M-Ras
著者Muraoka, S, Shima, F, Liao, J, Ijiri, Y, Matsumoto, K, Ye, M, Inoue, T, Kataoka, T.
登録日2009-11-06
公開日2010-06-16
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Structural basis for conformational dynamics of GTP-bound Ras protein
J.Biol.Chem., 285, 2010
1GWN
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BU of 1gwn by Molmil
The crystal structure of the core domain of RhoE/Rnd3 - a constitutively activated small G protein
分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Rho-related GTP-binding protein RhoE
著者Garavini, H, Riento, K, Phelan, J.P, McAlister, M.S.B, Ridley, A.J, Keep, N.H.
登録日2002-03-19
公開日2002-04-05
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structure of the Core Domain of Rhoe/Rnd3: A Constitutively Activated Small G Protein
Biochemistry, 41, 2002
4XVQ
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H-Ras Y137E
分子名称: GLYCEROL, GTPase HRas, MAGNESIUM ION, ...
著者Johnson, C.W, Mattos, C.
登録日2015-01-27
公開日2015-06-17
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.887 Å)
主引用文献Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding.
Faseb J., 29, 2015
1GNR
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BU of 1gnr by Molmil
X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP
分子名称: C-H-RAS P21 PROTEIN, GUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER], MAGNESIUM ION
著者Scheidig, A, Franken, S.M, Corrie, J.E.T, Reid, G.P, Wittinghofer, A, Pai, E.F, Goody, R.S.
登録日1995-05-11
公開日1995-07-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp.
J.Mol.Biol., 253, 1995
1HUQ
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BU of 1huq by Molmil
1.8A CRYSTAL STRUCTURE OF THE MONOMERIC GTPASE RAB5C (MOUSE)
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, RAB5C
著者Merithew, E, Hatherly, S, Dumas, J.J, Lawe, D.C, Heller-Harrison, R, Lambright, D.G.
登録日2001-01-04
公開日2001-02-07
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural plasticity of an invariant hydrophobic triad in the switch regions of Rab GTPases is a determinant of effector recognition.
J.Biol.Chem., 276, 2001
4XVR
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BU of 4xvr by Molmil
H-Ras Y137F
分子名称: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ...
著者Johnson, C.W, Mattos, C.
登録日2015-01-27
公開日2015-06-17
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.031 Å)
主引用文献Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding.
Faseb J., 29, 2015
6E6C
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BU of 6e6c by Molmil
HRAS G13D bound to GppNHp (H13GNP)
分子名称: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ...
著者Johnson, C.W, Mattos, C.
登録日2018-07-24
公開日2019-07-31
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D.
Cell Rep, 28, 2019
6E6H
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BU of 6e6h by Molmil
NRAS G13D bound to GppNHp (N13GNP)
分子名称: GTPase NRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Johnson, C.W, Mattos, C.
登録日2018-07-24
公開日2019-07-31
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D.
Cell Rep, 28, 2019
6FA3
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BU of 6fa3 by Molmil
Antibody derived (Abd-6) small molecule binding to KRAS.
分子名称: DIMETHYL SULFOXIDE, GTPase KRas, MAGNESIUM ION, ...
著者Quevedo, C.E, Cruz-Migoni, A, Ehebauer, M.T, Carr, S.B, Phillips, S.E.V, Rabbitts, T.H.
登録日2017-12-15
公開日2018-08-22
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.
Nat Commun, 9, 2018
6FA2
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Antibody derived (Abd-5) small molecule binding to KRAS.
分子名称: 4-[2-(dimethylamino)ethoxy]-~{N}-[[(3~{R})-5-(6-methoxypyridin-2-yl)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]benzamide, GTPase KRas, MAGNESIUM ION, ...
著者Quevedo, C.E, Cruz-Migoni, A, Ehebauer, M.T, Carr, S.B, Phillips, S.V.E, Rabbitts, T.H.
登録日2017-12-15
公開日2018-09-05
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.
Nat Commun, 9, 2018
6FA4
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BU of 6fa4 by Molmil
Antibody derived (Abd-7) small molecule binding to KRAS.
分子名称: 6-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[4-[(dimethylamino)methyl]phenyl]-2-methoxy-pyridin-3-amine, GTPase KRas, MAGNESIUM ION, ...
著者Quevedo, C.E, Cruz-Migoni, A, Ehebauer, M.T, Carr, S.B, Phillips, S.V.E, Rabbitts, T.H.
登録日2017-12-15
公開日2018-08-22
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.
Nat Commun, 9, 2018
6F76
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Antibody derived (Abd-8) small molecule binding to KRAS.
分子名称: 4-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[3-[(dimethylamino)methyl]phenyl]-2-methoxy-aniline, GTPase KRas, MAGNESIUM ION, ...
著者Bery, N, Cruz-Migoni, A, Quevedo, C.E, Phillips, S.V.E, Carr, S, Rabbitts, T.H.
登録日2017-12-07
公開日2018-08-08
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions.
Elife, 7, 2018
5WHE
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BU of 5whe by Molmil
KRas G12V/D38P, bound to GppNHp and miniprotein 225-11
分子名称: CALCIUM ION, GTPase KRas, MAGNESIUM ION, ...
著者Shim, S.Y, McGee, J.H, Lee, S.-J, Verdine, G.L.
登録日2017-07-16
公開日2018-01-03
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Exceptionally high-affinity Ras binders that remodel its effector domain.
J. Biol. Chem., 293, 2018
5WPL
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KRas G12V, bound to GppNHp and miniprotein 225-11
分子名称: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ...
著者Lee, S.-J, Shim, S.Y, McGee, J.H, Verdine, G.L.
登録日2017-08-05
公開日2018-01-03
最終更新日2018-03-14
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Exceptionally high-affinity Ras binders that remodel its effector domain.
J. Biol. Chem., 293, 2018

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