PDB: 1360 件ウェブページステータス検索Chemie searchBIRD

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2X1V	Crystal Structure of the activating H-Ras I163F mutant in Costello Syndrome, bound to MG-GDP 分子名称: GTPASE HRAS, GUANOSINE-5'-DIPHOSPHATE 著者 Anand, K. 登録日 2010-01-04 公開日 2010-01-12 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal Structure of the Activating H-Ras I163F Mutant in Costello Syndrome, Bound to Mg-Gdp To be Published
7NY8	Affimer K69 - KRAS protein complex 分子名称: Affimer K69, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Turner, A.L, Trinh, C.H, Haza, K.Z, Rao, A, Martin, H.L, Tiede, C, Edwards, T.A, McPherson, M.J, Tomlinson, D.C. 登録日 2021-03-21 公開日 2021-07-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 RAS-inhibiting biologics identify and probe druggable pockets including an SII-alpha 3 allosteric site. Nat Commun, 12, 2021
1QG4	CANINE GDP-RAN F72Y MUTANT 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PROTEIN (RAN) 著者 Kent, H.M, Moore, M.S, Quimby, B.B, Baker, A.M.E, McCoy, A.J, Murphy, G.A, Corbett, A.H, Stewart, M. 登録日 1999-04-20 公開日 1999-06-11 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Engineered mutants in the switch II loop of Ran define the contribution made by key residues to the interaction with nuclear transport factor 2 (NTF2) and the role of this interaction in nuclear protein import. J.Mol.Biol., 289, 1999
2KB0	Cdc42(T35A) 分子名称: Cell division control protein 42 homolog 著者 Adams, P.D, Oswald, R.E, McFeeters, R. 登録日 2008-11-18 公開日 2009-12-01 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Cdc42(T35A) To be Published
221P	THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES 分子名称: H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER 著者 Krengel, U, Scherer, A, Kabsch, W, Wittinghofer, A, Pai, E.F. 登録日 1991-06-06 公開日 1994-01-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules. Cell(Cambridge,Mass.), 62, 1990
1QRA	STRUCTURE OF P21RAS IN COMPLEX WITH GTP AT 100 K 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, TRANSFORMING PROTEIN P21/H-RAS-1 著者 Scheidig, A, Burmester, C, Goody, R.S. 登録日 1999-06-12 公開日 1999-11-05 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins. Structure Fold.Des., 7, 1999
2A5J	Crystal Structure of Human RAB2B 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-2B 著者 Dong, A, Wang, J, Shen, Y, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Bochkarev, A, Park, H.W, Structural Genomics Consortium (SGC) 登録日 2005-06-30 公開日 2005-07-19 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.501 Å) 主引用文献 Crystal structure of human RAB2B To be Published
5MLB	Crystal structure of human RAS in complex with darpin K27 分子名称: DARPin K27, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Debreczeni, J.E, Guillard, S, Kolasinska-Zwierz, P, Breed, J, Zhang, J, Bery, N, Marwood, R, Tart, J, Overman, R, Stocki, P, Mistry, B, Phillips, C, Rabbitts, T, Jackson, R, Minter, R. 登録日 2016-12-06 公開日 2017-12-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.22 Å) 主引用文献 INhibition of RAS nucleotide exchange by a DARPin: structural characterisation and effects on downstream signalling by active RAS To Be Published
2LCF	Solution structure of GppNHp-bound H-RasT35S mutant protein 分子名称: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER 著者 Araki, M, Shima, F, Yoshikawa, Y, Muraoka, S, Ijiri, Y, Nagahara, Y, Shirono, T, Kataoka, T, Tamura, A. 登録日 2011-04-28 公開日 2011-09-28 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers. J.Biol.Chem., 286, 2011
3KKQ	Crystal structure of M-Ras P40D in complex with GDP 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein M-Ras 著者 Muraoka, S, Shima, F, Liao, J, Ijiri, Y, Matsumoto, K, Ye, M, Inoue, T, Kataoka, T. 登録日 2009-11-06 公開日 2010-06-16 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Structural basis for conformational dynamics of GTP-bound Ras protein J.Biol.Chem., 285, 2010
3KKM	Crystal structure of H-Ras T35S in complex with GppNHp 分子名称: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Muraoka, S, Shima, F, Liao, J, Ijiri, Y, Matsumoto, K, Ye, M, Inoue, T, Kataoka, T. 登録日 2009-11-06 公開日 2010-06-16 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural basis for conformational dynamics of GTP-bound Ras protein J.Biol.Chem., 285, 2010
3KKP	Crystal structure of M-Ras P40D in complex with GppNHp 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein M-Ras 著者 Muraoka, S, Shima, F, Liao, J, Ijiri, Y, Matsumoto, K, Ye, M, Inoue, T, Kataoka, T. 登録日 2009-11-06 公開日 2010-06-16 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Structural basis for conformational dynamics of GTP-bound Ras protein J.Biol.Chem., 285, 2010
1GWN	The crystal structure of the core domain of RhoE/Rnd3 - a constitutively activated small G protein 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Rho-related GTP-binding protein RhoE 著者 Garavini, H, Riento, K, Phelan, J.P, McAlister, M.S.B, Ridley, A.J, Keep, N.H. 登録日 2002-03-19 公開日 2002-04-05 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structure of the Core Domain of Rhoe/Rnd3: A Constitutively Activated Small G Protein Biochemistry, 41, 2002
4XVQ	H-Ras Y137E 分子名称: GLYCEROL, GTPase HRas, MAGNESIUM ION, ... 著者 Johnson, C.W, Mattos, C. 登録日 2015-01-27 公開日 2015-06-17 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.887 Å) 主引用文献 Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding. Faseb J., 29, 2015
1GNR	X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP 分子名称: C-H-RAS P21 PROTEIN, GUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER], MAGNESIUM ION 著者 Scheidig, A, Franken, S.M, Corrie, J.E.T, Reid, G.P, Wittinghofer, A, Pai, E.F, Goody, R.S. 登録日 1995-05-11 公開日 1995-07-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp. J.Mol.Biol., 253, 1995
1HUQ	1.8A CRYSTAL STRUCTURE OF THE MONOMERIC GTPASE RAB5C (MOUSE) 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, RAB5C 著者 Merithew, E, Hatherly, S, Dumas, J.J, Lawe, D.C, Heller-Harrison, R, Lambright, D.G. 登録日 2001-01-04 公開日 2001-02-07 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural plasticity of an invariant hydrophobic triad in the switch regions of Rab GTPases is a determinant of effector recognition. J.Biol.Chem., 276, 2001
4XVR	H-Ras Y137F 分子名称: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... 著者 Johnson, C.W, Mattos, C. 登録日 2015-01-27 公開日 2015-06-17 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.031 Å) 主引用文献 Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding. Faseb J., 29, 2015
6E6C	HRAS G13D bound to GppNHp (H13GNP) 分子名称: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... 著者 Johnson, C.W, Mattos, C. 登録日 2018-07-24 公開日 2019-07-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D. Cell Rep, 28, 2019
6E6H	NRAS G13D bound to GppNHp (N13GNP) 分子名称: GTPase NRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER 著者 Johnson, C.W, Mattos, C. 登録日 2018-07-24 公開日 2019-07-31 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D. Cell Rep, 28, 2019
6FA3	Antibody derived (Abd-6) small molecule binding to KRAS. 分子名称: DIMETHYL SULFOXIDE, GTPase KRas, MAGNESIUM ION, ... 著者 Quevedo, C.E, Cruz-Migoni, A, Ehebauer, M.T, Carr, S.B, Phillips, S.E.V, Rabbitts, T.H. 登録日 2017-12-15 公開日 2018-08-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment. Nat Commun, 9, 2018
6FA2	Antibody derived (Abd-5) small molecule binding to KRAS. 分子名称: 4-[2-(dimethylamino)ethoxy]-~{N}-[[(3~{R})-5-(6-methoxypyridin-2-yl)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]benzamide, GTPase KRas, MAGNESIUM ION, ... 著者 Quevedo, C.E, Cruz-Migoni, A, Ehebauer, M.T, Carr, S.B, Phillips, S.V.E, Rabbitts, T.H. 登録日 2017-12-15 公開日 2018-09-05 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment. Nat Commun, 9, 2018
6FA4	Antibody derived (Abd-7) small molecule binding to KRAS. 分子名称: 6-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[4-[(dimethylamino)methyl]phenyl]-2-methoxy-pyridin-3-amine, GTPase KRas, MAGNESIUM ION, ... 著者 Quevedo, C.E, Cruz-Migoni, A, Ehebauer, M.T, Carr, S.B, Phillips, S.V.E, Rabbitts, T.H. 登録日 2017-12-15 公開日 2018-08-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment. Nat Commun, 9, 2018
6F76	Antibody derived (Abd-8) small molecule binding to KRAS. 分子名称: 4-(2,3-dihydro-1,4-benzodioxin-5-yl)-~{N}-[3-[(dimethylamino)methyl]phenyl]-2-methoxy-aniline, GTPase KRas, MAGNESIUM ION, ... 著者 Bery, N, Cruz-Migoni, A, Quevedo, C.E, Phillips, S.V.E, Carr, S, Rabbitts, T.H. 登録日 2017-12-07 公開日 2018-08-08 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions. Elife, 7, 2018
5WHE	KRas G12V/D38P, bound to GppNHp and miniprotein 225-11 分子名称: CALCIUM ION, GTPase KRas, MAGNESIUM ION, ... 著者 Shim, S.Y, McGee, J.H, Lee, S.-J, Verdine, G.L. 登録日 2017-07-16 公開日 2018-01-03 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Exceptionally high-affinity Ras binders that remodel its effector domain. J. Biol. Chem., 293, 2018
5WPL	KRas G12V, bound to GppNHp and miniprotein 225-11 分子名称: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... 著者 Lee, S.-J, Shim, S.Y, McGee, J.H, Verdine, G.L. 登録日 2017-08-05 公開日 2018-01-03 最終更新日 2018-03-14 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Exceptionally high-affinity Ras binders that remodel its effector domain. J. Biol. Chem., 293, 2018

 

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