7NY8

Affimer K69 - KRAS protein complex

Summary for 7NY8

Entry DOI	10.2210/pdb7ny8/pdb
Related	6YR8 6YXW
Descriptor	GTPase KRas, Affimer K69, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywords	protein complex, affimer, kras, inhibitor, protein binding
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	64785.17
Authors	Turner, A.L.,Trinh, C.H.,Haza, K.Z.,Rao, A.,Martin, H.L.,Tiede, C.,Edwards, T.A.,McPherson, M.J.,Tomlinson, D.C. (deposition date: 2021-03-21, release date: 2021-07-07, Last modification date: 2024-01-31)
Primary citation	Haza, K.Z.,Martin, H.L.,Rao, A.,Turner, A.L.,Saunders, S.E.,Petersen, B.,Tiede, C.,Tipping, K.,Tang, A.A.,Ajayi, M.,Taylor, T.,Harvey, M.,Fishwick, K.M.,Adams, T.L.,Gaule, T.G.,Trinh, C.H.,Johnson, M.,Breeze, A.L.,Edwards, T.A.,McPherson, M.J.,Tomlinson, D.C. RAS-inhibiting biologics identify and probe druggable pockets including an SII-alpha 3 allosteric site. Nat Commun, 12:4045-4045, 2021 Cited by PubMed: 34193876 DOI: 10.1038/s41467-021-24316-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation