6YR8

Affimer K6 - KRAS protein complex

Summary for 6YR8

Entry DOI	10.2210/pdb6yr8/pdb
Descriptor	GTPase KRas, Affimer K6, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywords	protein complex, affimer, kras, inhibitor, protein binding
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	32254.57
Authors	Trinh, C.H.,Haza, K.Z.,Rao, A.,Martin, H.L.,Tiede, C.,Edwards, T.A.,McPherson, M.J.,Tomlinson, D.C. (deposition date: 2020-04-19, release date: 2020-07-08, Last modification date: 2024-01-24)
Primary citation	Haza, K.Z.,Martin, H.L.,Rao, A.,Turner, A.L.,Saunders, S.E.,Petersen, B.,Tiede, C.,Tipping, K.,Tang, A.A.,Ajayi, M.,Taylor, T.,Harvey, M.,Fishwick, K.M.,Adams, T.L.,Gaule, T.G.,Trinh, C.H.,Johnson, M.,Breeze, A.L.,Edwards, T.A.,McPherson, M.J.,Tomlinson, D.C. RAS-inhibiting biologics identify and probe druggable pockets including an SII-alpha 3 allosteric site. Nat Commun, 12:4045-4045, 2021 Cited by PubMed: 34193876 DOI: 10.1038/s41467-021-24316-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation