Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5DLV

Crystal structure of Autotaxin (ENPP2) with tauroursodeoxycholic acid (TUDCA)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001953	biological_process	negative regulation of cell-matrix adhesion
A	0003676	molecular_function	nucleic acid binding
A	0004528	molecular_function	phosphodiesterase I activity
A	0004622	molecular_function	lysophospholipase activity
A	0005044	molecular_function	scavenger receptor activity
A	0005509	molecular_function	calcium ion binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006644	biological_process	phospholipid metabolic process
A	0006935	biological_process	chemotaxis
A	0006955	biological_process	immune response
A	0008270	molecular_function	zinc ion binding
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009395	biological_process	phospholipid catabolic process
A	0010634	biological_process	positive regulation of epithelial cell migration
A	0016042	biological_process	lipid catabolic process
A	0016192	biological_process	vesicle-mediated transport
A	0016787	molecular_function	hydrolase activity
A	0016788	molecular_function	hydrolase activity, acting on ester bonds
A	0030149	biological_process	sphingolipid catabolic process
A	0030247	molecular_function	polysaccharide binding
A	0030334	biological_process	regulation of cell migration
A	0034638	biological_process	phosphatidylcholine catabolic process
A	0044849	biological_process	estrous cycle
A	0046872	molecular_function	metal ion binding
A	0047391	molecular_function	alkylglycerophosphoethanolamine phosphodiesterase activity
A	0048714	biological_process	positive regulation of oligodendrocyte differentiation
A	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
A	0051894	biological_process	positive regulation of focal adhesion assembly
A	0060326	biological_process	cell chemotaxis
A	0071276	biological_process	cellular response to cadmium ion
A	0071392	biological_process	cellular response to estradiol stimulus
A	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
A	1903165	biological_process	response to polycyclic arene
A	2000394	biological_process	positive regulation of lamellipodium morphogenesis
B	0001953	biological_process	negative regulation of cell-matrix adhesion
B	0003676	molecular_function	nucleic acid binding
B	0004528	molecular_function	phosphodiesterase I activity
B	0004622	molecular_function	lysophospholipase activity
B	0005044	molecular_function	scavenger receptor activity
B	0005509	molecular_function	calcium ion binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006644	biological_process	phospholipid metabolic process
B	0006935	biological_process	chemotaxis
B	0006955	biological_process	immune response
B	0008270	molecular_function	zinc ion binding
B	0008284	biological_process	positive regulation of cell population proliferation
B	0009395	biological_process	phospholipid catabolic process
B	0010634	biological_process	positive regulation of epithelial cell migration
B	0016042	biological_process	lipid catabolic process
B	0016192	biological_process	vesicle-mediated transport
B	0016787	molecular_function	hydrolase activity
B	0016788	molecular_function	hydrolase activity, acting on ester bonds
B	0030149	biological_process	sphingolipid catabolic process
B	0030247	molecular_function	polysaccharide binding
B	0030334	biological_process	regulation of cell migration
B	0034638	biological_process	phosphatidylcholine catabolic process
B	0044849	biological_process	estrous cycle
B	0046872	molecular_function	metal ion binding
B	0047391	molecular_function	alkylglycerophosphoethanolamine phosphodiesterase activity
B	0048714	biological_process	positive regulation of oligodendrocyte differentiation
B	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
B	0051894	biological_process	positive regulation of focal adhesion assembly
B	0060326	biological_process	cell chemotaxis
B	0071276	biological_process	cellular response to cadmium ion
B	0071392	biological_process	cellular response to estradiol stimulus
B	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
B	1903165	biological_process	response to polycyclic arene
B	2000394	biological_process	positive regulation of lamellipodium morphogenesis

Functional Information from PROSITE/UniProt

site_id	PS00524
Number of Residues	21
Details	SMB_1 Somatomedin B domain (SMB) signature. CrCdnlCksyss.CChDFdelC

Chain	Residue	Details
A	CYS73-CYS93
A	CYS117-CYS137

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000269\|PubMed:12633853, ECO:0000269\|PubMed:27268273

Chain	Residue	Details
A	THR209
B	THR209

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:21240271, ECO:0000269\|PubMed:27075612, ECO:0000269\|PubMed:27268273, ECO:0000269\|PubMed:27660691, ECO:0007744\|PDB:2XR9, ECO:0007744\|PDB:2XRG, ECO:0007744\|PDB:5DLT, ECO:0007744\|PDB:5DLV, ECO:0007744\|PDB:5DLW, ECO:0007744\|PDB:5IJQ, ECO:0007744\|PDB:5IJS, ECO:0007744\|PDB:5L0B, ECO:0007744\|PDB:5L0E, ECO:0007744\|PDB:5L0K, ECO:0007744\|PDB:5LQQ

Chain	Residue	Details
A	ASP171
B	HIS315
B	HIS359
B	HIS474
A	THR209
A	ASP311
A	HIS315
A	HIS359
A	HIS474
B	ASP171
B	THR209
B	ASP311

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q9R1E6

Chain	Residue	Details
A	PHE210
A	LEU243
B	PHE210
B	LEU243

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305\|PubMed:27075612, ECO:0007744\|PDB:5DLW

Chain	Residue	Details
A	ASN230
B	ASN230

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305\|PubMed:27075612, ECO:0007744\|PDB:5DLV, ECO:0007744\|PDB:5DLW

Chain	Residue	Details
A	TYR306
B	TYR306

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:21240271, ECO:0000269\|PubMed:27075612, ECO:0000269\|PubMed:27268273, ECO:0000269\|PubMed:27660691, ECO:0007744\|PDB:2XRG, ECO:0007744\|PDB:5DLT, ECO:0007744\|PDB:5DLV, ECO:0007744\|PDB:5IJS, ECO:0007744\|PDB:5L0B, ECO:0007744\|PDB:5L0E, ECO:0007744\|PDB:5L0K, ECO:0007744\|PDB:5LQQ

Chain	Residue	Details
A	ASP358
B	ASP358

site_id	SWS_FT_FI7
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:21240271, ECO:0000269\|PubMed:27075612, ECO:0000269\|PubMed:27268273, ECO:0007744\|PDB:2XR9, ECO:0007744\|PDB:2XRG, ECO:0007744\|PDB:5DLT, ECO:0007744\|PDB:5DLV, ECO:0007744\|PDB:5DLW, ECO:0007744\|PDB:5IJQ, ECO:0007744\|PDB:5L0K, ECO:0007744\|PDB:5LQQ

Chain	Residue	Details
A	PRO764
B	PRO764

site_id	SWS_FT_FI8
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:21240271, ECO:0000269\|PubMed:27075612, ECO:0000269\|PubMed:27268273, ECO:0007744\|PDB:2XR9, ECO:0007744\|PDB:2XRG, ECO:0007744\|PDB:5DLT, ECO:0007744\|PDB:5DLV, ECO:0007744\|PDB:5DLW, ECO:0007744\|PDB:5IJQ, ECO:0007744\|PDB:5IJS, ECO:0007744\|PDB:5L0K, ECO:0007744\|PDB:5LQQ

Chain	Residue	Details
A	HIS766
A	TYR768
A	THR772
B	HIS766
B	TYR768
B	THR772

site_id	SWS_FT_FI9
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:21240271, ECO:0000269\|PubMed:27075612, ECO:0000269\|PubMed:27268273, ECO:0007744\|PDB:2XR9, ECO:0007744\|PDB:2XRG, ECO:0007744\|PDB:5DLT, ECO:0007744\|PDB:5DLV, ECO:0007744\|PDB:5DLW, ECO:0007744\|PDB:5IJQ, ECO:0007744\|PDB:5IJS, ECO:0007744\|PDB:5L0K

Chain	Residue	Details
A	ILE770
B	ILE770

site_id	SWS_FT_FI10
Number of Residues	10
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN53
B	HIS831
A	ASN398
A	ALA410
A	ASP610
A	HIS831
B	ASN53
B	ASN398
B	ALA410
B	ASP610

site_id	SWS_FT_FI11
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:21240271

Chain	Residue	Details
A	ASN524
B	ASN524

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)