5DLV

Crystal structure of Autotaxin (ENPP2) with tauroursodeoxycholic acid (TUDCA)

Summary for 5DLV

Entry DOI	10.2210/pdb5dlv/pdb
Related	5DLT
Descriptor	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, THIOCYANATE ION, GLYCEROL, ... (12 entities in total)
Functional Keywords	autotaxin, enpp2, lpa, steroids, bile salts, tudca, hydrolase
Biological source	Rattus norvegicus (Norway Rat)
Total number of polymer chains	2
Total formula weight	199096.65
Authors	Keune, W.J.,Heidebrecht, T.,von Castelmur, E.,Joosten, R.P.,Perrakis, A. (deposition date: 2015-09-07, release date: 2016-04-13, Last modification date: 2024-01-10)
Primary citation	Keune, W.J.,Hausmann, J.,Bolier, R.,Tolenaars, D.,Kremer, A.,Heidebrecht, T.,Joosten, R.P.,Sunkara, M.,Morris, A.J.,Matas-Rico, E.,Moolenaar, W.H.,Oude Elferink, R.P.,Perrakis, A. Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling. Nat Commun, 7:11248-11248, 2016 Cited by PubMed: 27075612 DOI: 10.1038/ncomms11248 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation