5DLV
Crystal structure of Autotaxin (ENPP2) with tauroursodeoxycholic acid (TUDCA)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | polymer | 827 | 95003.6 | 2 | UniProt (Q64610) Pfam (PF01033) Pfam (PF01663) Pfam (PF01223) In PDB | Rattus norvegicus (Norway Rat) | E-NPP 2,Autotaxin,Extracellular lysophospholipase D,LysoPLD |
| 2 | C | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1559.4 | 1 | In PDB GlyTouCan (G37135JQ) | |||
| 3 | D | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G16404YH) | |||
| 4 | A, B | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 5 | A, B | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 6 | A, B | IODIDE ION | non-polymer | 126.9 | 27 | Chemie (IOD) | |||
| 7 | A, B | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 8 | A, B | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) | |||
| 9 | B, A | 2-{[(3alpha,5beta,7alpha,8alpha,14beta,17alpha)-3,7-dihydroxy-24-oxocholan-24-yl]amino}ethanesulfonic acid | non-polymer | 499.7 | 2 | Chemie (5D5) | |||
| 10 | A, B | THIOCYANATE ION | non-polymer | 58.1 | 4 | Chemie (SCN) | |||
| 11 | A, B | GLYCEROL | non-polymer | 92.1 | 11 | Chemie (GOL) | |||
| 12 | water | water | 18.0 | 587 | Chemie (HOH) |
Sequence modifications
A, B: 36 - 862 (UniProt: Q64610)
| PDB | External Database | Details |
|---|---|---|
| Ala 410 | Asn 410 | engineered mutation |
| Thr 591 | Arg 591 | cloning artifact |
| Ala 806 | Asn 806 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 190007.3 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 2794.5 | |
| Non-Polymers* | Number of molecules | 56 |
| Total formula weight | 6294.9 | |
| All* | Total formula weight | 199096.6 |
