5LQQ

Structure of Autotaxin (ENPP2) with LM350

Summary for 5LQQ

• Entry DOI: 10.2210/pdb5lqq/pdb
• Descriptor: Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (8 entities in total)
• Functional Keywords: autotaxin, enpp2, inhibitor, lm350, ectonucleotide pyrophosphatase/phosphodiesterase, hydrolase
• Biological source: Rattus norvegicus (Norway Rat)
• Total number of polymer chains: 1
• Total formula weight: 98291.71

Authors

Keune, W.J.,Heidebrecht, T.,Castelmur, E.,Joosten, R.P.,Perrakis, A. (deposition date: 2016-08-17, release date: 2016-12-28, Last modification date: 2024-01-10)

• Primary citation: Miller, L.M.,Keune, W.J.,Castagna, D.,Young, L.C.,Duffy, E.L.,Potjewyd, F.,Salgado-Polo, F.,Engel Garcia, P.,Semaan, D.,Pritchard, J.M.,Perrakis, A.,Macdonald, S.J.,Jamieson, C.,Watson, A.J.; Structure-Activity Relationships of Small Molecule Autotaxin Inhibitors with a Discrete Binding Mode.; J. Med. Chem., 60:722-748, 2017; PubMed: 27982588; DOI: 10.1021/acs.jmedchem.6b01597

Experimental method

X-RAY DIFFRACTION (2.4 Å)