5B16

X-ray structure of DROSHA in complex with the C-terminal tail of DGCR8.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0004525	molecular_function	ribonuclease III activity
A	0006364	biological_process	rRNA processing
A	0006396	biological_process	RNA processing
A	0031054	biological_process	pre-miRNA processing

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1401

Chain	Residue
A	CYS561
A	HIS609
A	CYS676
A	HIS680

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site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1402

Chain	Residue
A	CYS536
A	CYS538
A	HIS549
A	HIS1026

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Functional Information from PROSITE/UniProt

site_id	PS00517
Number of Residues	9
Details	RNASE_3_1 Ribonuclease III family signature. ERLEFLGDA

Chain	Residue	Details
A	GLU966-ALA974
A	GLN1144-SER1152

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:26748718

Chain	Residue	Details
A	HIS609
A	CYS676
A	HIS680
A	HIS1026
A	CYS561
A	CYS536
A	CYS538
A	HIS549

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:O67082

Chain	Residue	Details
A	GLU969
A	ASN1042
A	GLU1147
A	ASP1219

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:O67082, ECO:0000305|PubMed:15574589

Chain	Residue	Details
A	GLN1045
A	GLN1222

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Important for activity => ECO:0000250

Chain	Residue	Details
A	LYS1215

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