4N5G
Crystal Structure of RXRa LBD complexed with a synthetic modulator K8012
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003707 | molecular_function | nuclear steroid receptor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008270 | molecular_function | zinc ion binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003707 | molecular_function | nuclear steroid receptor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0008270 | molecular_function | zinc ion binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003707 | molecular_function | nuclear steroid receptor activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0008270 | molecular_function | zinc ion binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003707 | molecular_function | nuclear steroid receptor activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0008270 | molecular_function | zinc ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE K09 A 501 |
| Chain | Residue |
| A | TRP305 |
| A | LEU433 |
| A | LEU436 |
| A | PHE437 |
| A | PHE438 |
| A | PHE439 |
| A | ILE442 |
| A | GLY443 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE K09 D 501 |
| Chain | Residue |
| D | LEU433 |
| D | LEU436 |
| D | PHE437 |
| D | PHE438 |
| D | PHE439 |
| D | ILE442 |
| D | GLY443 |
| D | HOH637 |
| D | TRP305 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6 |
| Chain | Residue | Details |
| A | ARG316 | |
| A | ALA327 | |
| B | ARG316 | |
| B | ALA327 | |
| C | ARG316 | |
| C | ALA327 | |
| D | ARG316 | |
| D | ALA327 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER259 | |
| B | SER259 | |
| C | SER259 | |
| D | SER259 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by MAPK8 and MAPK9 => ECO:0000250|UniProtKB:P28700 |
| Chain | Residue | Details |
| A | SER260 | |
| B | SER260 | |
| C | SER260 | |
| D | SER260 |
