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4N5G

Crystal Structure of RXRa LBD complexed with a synthetic modulator K8012

Summary for 4N5G
Entry DOI10.2210/pdb4n5g/pdb
DescriptorRetinoic acid receptor RXR-alpha, 5-(2-{(1Z)-5-fluoro-2-methyl-1-[4-(propan-2-yl)benzylidene]-1H-inden-3-yl}ethyl)-1H-tetrazole (3 entities in total)
Functional Keywordsretinoid x receptor-alpha nuclear receptor, nucleus, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationNucleus: P19793
Total number of polymer chains4
Total formula weight109826.96
Authors
Aleshin, A.E.,Su, Y.,Zhang, X.,Liddington, R.C. (deposition date: 2013-10-09, release date: 2014-05-14, Last modification date: 2023-09-20)
Primary citationChen, L.,Wang, Z.G.,Aleshin, A.E.,Chen, F.,Chen, J.,Jiang, F.,Alitongbieke, G.,Zeng, Z.,Ma, Y.,Huang, M.,Zhou, H.,Cadwell, G.,Zheng, J.F.,Huang, P.Q.,Liddington, R.C.,Zhang, X.K.,Su, Y.
Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site.
Chem.Biol., 21:596-607, 2014
Cited by
PubMed: 24704507
DOI: 10.1016/j.chembiol.2014.02.017
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.11 Å)
Structure validation

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