4EDW

Nerve Growth Factor in Complex with Fab from humanized version of mouse mAb 911 (tanezumab)

Functional Information from GO Data

Chain	GOid	namespace	contents
V	0005102	molecular_function	signaling receptor binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL H 301

Chain	Residue
H	PHE166
H	PRO167
H	VAL169
H	SER177
H	LEU178
H	SER179
L	GLN160
L	SER176
L	THR178

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Functional Information from PROSITE/UniProt

site_id	PS00248
Number of Residues	14
Details	NGF_1 Nerve growth factor family signature. GCRGIDskhWnSyC

Chain	Residue	Details
V	GLY67-CYS80

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
L	TYR192-HIS198
H	TYR194-HIS200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: in other chain => ECO:0000250|UniProtKB:P01139

Chain	Residue	Details
V	TYR52

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P01139

Chain	Residue	Details
V	LYS88

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