4EDW

Nerve Growth Factor in Complex with Fab from humanized version of mouse mAb 911 (tanezumab)

Summary for 4EDW

• Entry DOI: 10.2210/pdb4edw/pdb
• Related: 4EDX
• Descriptor: Beta-nerve growth factor, tanezumab Fab light chain, tanezumab Fab heavy chain, ... (5 entities in total)
• Functional Keywords: cystine knot, immunoglobulin, growth/survival factor, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P01138
• Total number of polymer chains: 3
• Total formula weight: 62188.41

Authors

Eigenbrot, C.,Ultsch, M. (deposition date: 2012-03-27, release date: 2014-04-02, Last modification date: 2017-10-25)

• Primary citation: La Porte, S.L.,Eigenbrot, C.,Ultsch, M.,Ho, W.H.,Foletti, D.,Forgie, A.,Lindquist, K.C.,Shelton, D.L.,Pons, J.; Generation of a high-fidelity antibody against nerve growth factor using library scanning mutagenesis and validation with structures of the initial and optimized Fab-antigen complexes.; MAbs, 6:1059-1068, ; PubMed: 24830649

Experimental method

X-RAY DIFFRACTION (2.48 Å)