2OO4
| Structure of LNR-HD (Negative Regulatory Region) from human Notch 2 | Descriptor: | CALCIUM ION, GLYCEROL, Neurogenic locus notch homolog protein 2, ... | Authors: | Gordon, W.R, Vardar-Ulu, D, Histen, G, Sanchez-Irizarry, C, Aster, J.C, Blacklow, S.C. | Deposit date: | 2007-01-25 | Release date: | 2007-04-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.003 Å) | Cite: | Structural basis for autoinhibition of Notch Nat.Struct.Mol.Biol., 14, 2007
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1PB5
| NMR Structure of a Prototype LNR Module from Human Notch1 | Descriptor: | CALCIUM ION, Neurogenic locus notch homolog protein 1 | Authors: | Vardar, D, North, C.L, Sanchez-Irizarry, C, Aster, J.C, Blacklow, S.C. | Deposit date: | 2003-05-14 | Release date: | 2003-06-17 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Nuclear Magnetic Resonance Structure of a Prototype Lin12-Notch Repeat Module from Human Notch1 Biochemistry, 42, 2003
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4ZLP
| Crystal Structure of Notch3 Negative Regulatory Region | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CALCIUM ION, ... | Authors: | Xu, X, Blacklow, S.C. | Deposit date: | 2015-05-01 | Release date: | 2015-08-19 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.479 Å) | Cite: | Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region. Structure, 23, 2015
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6PY8
| Crystal structure of the RBPJ-NOTCH1-NRARP ternary complex bound to DNA | Descriptor: | DNA, Neurogenic locus notch homolog protein 1, Notch-regulated ankyrin repeat-containing protein, ... | Authors: | Jarrett, S.M, Seegar, T.C.M, Blacklow, S.C. | Deposit date: | 2019-07-29 | Release date: | 2019-08-14 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.75 Å) | Cite: | Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling. Sci.Signal., 12, 2019
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2F8Y
| Crystal structure of human Notch1 ankyrin repeats to 1.55A resolution. | Descriptor: | Notch homolog 1, translocation-associated (Drosophila), SULFATE ION | Authors: | Nam, Y, Sliz, P, Blacklow, S.C. | Deposit date: | 2005-12-04 | Release date: | 2006-04-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell(Cambridge,Mass.), 124, 2006
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3I08
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2F8X
| Crystal structure of activated Notch, CSL and MAML on HES-1 promoter DNA sequence | Descriptor: | 5'-D(*GP*TP*TP*AP*CP*TP*GP*TP*GP*GP*GP*AP*AP*AP*GP*AP*AP*A)-3', 5'-D(*TP*TP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*AP*GP*TP*AP*AP*C)-3', Mastermind-like protein 1, ... | Authors: | Nam, Y, Sliz, P, Blacklow, S.C. | Deposit date: | 2005-12-04 | Release date: | 2006-04-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell(Cambridge,Mass.), 124, 2006
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3NBN
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5CZV
| Crystal structure of Notch3 NRR in complex with 20350 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Fab 20350 heavy chain, ... | Authors: | Hu, T, Fryer, C, Chopra, R, Clark, K. | Deposit date: | 2015-08-01 | Release date: | 2016-06-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.19 Å) | Cite: | Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene, 35, 2016
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5CZX
| Crystal structure of Notch3 NRR in complex with 20358 Fab | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 20358 Fab heavy chain, ... | Authors: | Hu, T, Fryer, C, Chopra, R, Clark, K. | Deposit date: | 2015-08-01 | Release date: | 2016-06-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene, 35, 2016
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3ETO
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