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2OO4

Structure of LNR-HD (Negative Regulatory Region) from human Notch 2

Summary for 2OO4
Entry DOI10.2210/pdb2oo4/pdb
DescriptorNeurogenic locus notch homolog protein 2, CALCIUM ION, ZINC ION, ... (5 entities in total)
Functional Keywordsalpha-beta-sandwich; sea domain; lnr; lin12 notch repeat; cysteine-rich; hd domain, cell cycle, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationNotch 2 extracellular truncation: Cell membrane ; Single-pass type I membrane protein . Notch 2 intracellular domain: Nucleus : Q04721
Total number of polymer chains2
Total formula weight52972.31
Authors
Gordon, W.R.,Vardar-Ulu, D.,Histen, G.,Sanchez-Irizarry, C.,Aster, J.C.,Blacklow, S.C. (deposition date: 2007-01-25, release date: 2007-04-03, Last modification date: 2023-12-27)
Primary citationGordon, W.R.,Vardar-Ulu, D.,Histen, G.,Sanchez-Irizarry, C.,Aster, J.C.,Blacklow, S.C.
Structural basis for autoinhibition of Notch
Nat.Struct.Mol.Biol., 14:295-300, 2007
Cited by
PubMed: 17401372
DOI: 10.1038/nsmb1227
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.003 Å)
Structure validation

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