5CZV

Crystal structure of Notch3 NRR in complex with 20350 Fab

Summary for 5CZV

• Entry DOI: 10.2210/pdb5czv/pdb
• Related: 5CZX
• Descriptor: Neurogenic locus notch homolog protein 3, Fab 20350 heavy chain, Fab 20350 light chain, ... (6 entities in total)
• Functional Keywords: antibody, notch3, oncology, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 77789.93

Authors

Hu, T.,Fryer, C.,Chopra, R.,Clark, K. (deposition date: 2015-08-01, release date: 2016-06-01, Last modification date: 2023-09-27)

• Primary citation: Bernasconi-Elias, P.,Hu, T.,Jenkins, D.,Firestone, B.,Gans, S.,Kurth, E.,Capodieci, P.,Deplazes-Lauber, J.,Petropoulos, K.,Thiel, P.,Ponsel, D.,Hee Choi, S.,LeMotte, P.,London, A.,Goetcshkes, M.,Nolin, E.,Jones, M.D.,Slocum, K.,Kluk, M.J.,Weinstock, D.M.,Christodoulou, A.,Weinberg, O.,Jaehrling, J.,Ettenberg, S.A.,Buckler, A.,Blacklow, S.C.,Aster, J.C.,Fryer, C.J.; Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies.; Oncogene, 35:6077-6086, 2016; PubMed: 27157619; DOI: 10.1038/onc.2016.133

Experimental method

X-RAY DIFFRACTION (3.19 Å)