PDB: 37 件ウェブページステータス検索Chemie searchBIRD

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5HT6	Crystal structure of the SET domain of the human MLL5 methyltransferase 分子名称: Histone-lysine N-methyltransferase 2E 著者 le Maire, A, Mas-y-Mas, S, Dumas, C, Lebedev, A. 登録日 2016-01-26 公開日 2016-11-16 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.093 Å) 主引用文献 The Human Mixed Lineage Leukemia 5 (MLL5), a Sequentially and Structurally Divergent SET Domain-Containing Protein with No Intrinsic Catalytic Activity. Plos One, 11, 2016
5JJ0	Structure of G9a SET-domain with Histone H3K9M peptide and excess SAH 分子名称: Histone H3K9M mutant peptide, Histone-lysine N-methyltransferase EHMT2, S-ADENOSYLMETHIONINE, ... 著者 Jayaram, H, Bellon, S.F, Poy, F. 登録日 2016-04-22 公開日 2016-07-06 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3. Proc.Natl.Acad.Sci.USA, 113, 2016
5JHN	Structure of G9a SET-domain with Histone H3K9Ala mutant peptide and bound S-adenosylmethionine 分子名称: Histone H3.1 peptide with K9A mutation, Histone-lysine N-methyltransferase EHMT2, S-ADENOSYLMETHIONINE, ... 著者 Jayaram, H, Bellon, S.F, Poy, F. 登録日 2016-04-21 公開日 2016-07-06 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3. Proc.Natl.Acad.Sci.USA, 113, 2016
5JIY	Structure of G9a SET-domain with Histone H3K9norLeucine mutant peptide and bound S-adenosylmethionine 分子名称: Histone H3.1 mutant peptide with H3K9nor-leucine, Histone-lysine N-methyltransferase EHMT2, S-ADENOSYLMETHIONINE, ... 著者 Jayaram, H, Bellon, S.F, Poy, F. 登録日 2016-04-22 公開日 2016-09-14 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3. Proc.Natl.Acad.Sci.USA, 113, 2016
5JIN	Structure of G9a SET-domain with Histone H3K9M mutant peptide and bound S-adenosylmethionine 分子名称: Histone H3.1 peptide with K9M mutation, Histone-lysine N-methyltransferase EHMT2, S-ADENOSYLMETHIONINE, ... 著者 Jayaram, H, Bellon, S.F, Poy, F. 登録日 2016-04-22 公開日 2016-07-06 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3. Proc.Natl.Acad.Sci.USA, 113, 2016
6KIX	Cryo-EM structure of human MLL1-NCP complex, binding mode1 分子名称: DNA (145-MER), GLUTAMINE, Histone H2A, ... 著者 Huang, J, Xue, H, Yao, T. 登録日 2019-07-20 公開日 2019-09-11 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
6KIV	Cryo-EM structure of human MLL1-ubNCP complex (4.0 angstrom) 分子名称: DNA (145-MER), Histone H2A, Histone H2B 1.1, ... 著者 Huang, J, Xue, H, Yao, T. 登録日 2019-07-20 公開日 2019-09-11 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
6KIZ	Cryo-EM structure of human MLL1-NCP complex, binding mode2 分子名称: DNA (145-MER), Histone H2A, Histone H2B 1.1, ... 著者 Huang, J, Xue, H, Yao, T. 登録日 2019-07-20 公開日 2019-09-11 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
6KIU	Cryo-EM structure of human MLL1-ubNCP complex (3.2 angstrom) 分子名称: DNA (145-MER), GLUTAMINE, Histone H2A, ... 著者 Huang, J, Xue, H, Yao, T. 登録日 2019-07-20 公開日 2019-09-11 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
6KIW	Cryo-EM structure of human MLL3-ubNCP complex (4.0 angstrom) 分子名称: DNA (144-MER), DNA (145-MER), Histone H2A, ... 著者 Huang, J, Xue, H, Yao, T. 登録日 2019-07-20 公開日 2019-09-11 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
3SMR	Crystal structure of human WD repeat domain 5 with compound 分子名称: 1,2-ETHANEDIOL, 2-chloro-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide, UNKNOWN ATOM OR ION, ... 著者 Dong, A, Dombrovski, L, Wasney, G.A, Tempel, W, Senisterra, G, Bolshan, Y, Smil, D, Nguyen, K.T, Hajian, T, Poda, G, Al-Awar, R, Bountra, C, Weigelt, J, Edwards, A.M, Brown, P.J, Schapira, M, Arrowsmith, C.H, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC) 登録日 2011-06-28 公開日 2011-08-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem. J., 449, 2013
6BX3	Structure of histone H3k4 methyltransferase 分子名称: COMPASS component BRE2, COMPASS component SDC1, COMPASS component SPP1, ... 著者 Skiniotis, G, Qu, Q.H. 登録日 2017-12-16 公開日 2018-09-05 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex. Cell, 174, 2018

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