PDB: 30548 resultsInfo pagesStatus searchChemie searchBIRD

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8QIC	Structure-based identification of salicylic acid derivatives as malarial threonyl tRNA-synthetase inhibitors Descriptor: 2-oxidanyl-5-[[4-(phenylmethyl)phenyl]sulfamoyl]benzoic acid, GLYCEROL, Threonine--tRNA ligase, ... Authors: Rodriguez, J.A, Parisini, E. Deposit date: 2023-09-13 Release date: 2024-04-10 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure-based identification of salicylic acid derivatives as malarial threonyl tRNA-synthetase inhibitors. Plos One, 19, 2024
8U5T	Structure of Mango II variant aptamer bound to T01-6A-B Descriptor: 3-{2,16-dioxo-20-[(3aS,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-6,9,12-trioxa-3,15-diazaicosan-1-yl}-2-{(E)-[6-(4-methoxyphenyl)-1-methylquinolin-4(1H)-ylidene]methyl}-1,3-benzothiazol-3-ium, Mango II variant, POTASSIUM ION, ... Authors: Passalacqua, L.F.M, Ferre-D'Amare, A.R. Deposit date: 2023-09-12 Release date: 2024-03-27 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure of Mango II variant aptamer bound to T01-6A-B To Be Published
8U5P	Structure of Mango II aptamer bound to T01-6A-B Descriptor: 3-[2,16-dioxo-20-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-6,9,12-trioxa-3,15-diazaicosan-1-yl]-2-{(E)-[6-(4-methoxyphenyl)-1-methylquinolin-4(1H)-ylidene]methyl}-1,3-benzothiazol-3-ium, Mango II, POTASSIUM ION Authors: Passalacqua, L.F.M, Ferre-D'Amare, A.R. Deposit date: 2023-09-12 Release date: 2024-03-27 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structure of Mango II aptamer bound to T01-6A-B To Be Published
8U5R	Structure of Mango II variant aptamer bound to T01-6A Descriptor: Mango II variant, POTASSIUM ION, SODIUM ION Authors: Passalacqua, L.F.M, Ferre-D'Amare, A.R. Deposit date: 2023-09-12 Release date: 2024-03-27 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure of Mango II variant aptamer bound to T01-6A To Be Published
8U5K	Structure of Mango II aptamer bound to T01-6A Descriptor: 2-[(~{E})-[6-(4-methoxyphenyl)-1-methyl-quinolin-4-ylidene]methyl]-3-methyl-1,3-benzothiazole, Mango II, POTASSIUM ION Authors: Passalacqua, L.F.M, Ferre-D'Amare, A.R. Deposit date: 2023-09-12 Release date: 2024-03-27 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure of Mango II aptamer bound to T01-6A To Be Published
8U5J	Structure of Mango III variant aptamer bound to T01-07M-B Descriptor: 2-[(E)-(1,7-dimethylquinolin-4(1H)-ylidene)methyl]-3-{2,16-dioxo-20-[(3aR,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-6,9,12-trioxa-3,15-diazaicosan-1-yl}-1,3-benzothiazol-3-ium, DIMETHYL SULFOXIDE, Mango III variant, ... Authors: Passalacqua, L.F.M, Ferre-D'Amare, A.R. Deposit date: 2023-09-12 Release date: 2024-03-27 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structure of Mango III variant aptamer bound to T01-07M-B To Be Published
8QJ7	Cryo-EM structure of human DNA polymerase alpha-primase in pre-initiation stage 1 Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, ... Authors: Yin, Z, Pellegrini, L. Deposit date: 2023-09-12 Release date: 2024-02-21 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.07 Å) Cite: CryoEM insights into RNA primer synthesis by the human primosome. Febs J., 291, 2024
8WCE	Cryo-EM structure of a protein-RNA complex Descriptor: MAGNESIUM ION, RNA (31-MER), RNA (66-MER), ... Authors: Li, Z. Deposit date: 2023-09-11 Release date: 2024-05-22 Method: ELECTRON MICROSCOPY (3.09 Å) Cite: Molecular mechanism for target RNA recognition and cleavage of Cas13h. Nucleic Acids Res., 2024
8U3Y	SpG Cas9 with NGG PAM DNA target Descriptor: CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(P*CP*GP*TP*TP*TP*GP*TP*AP*CP*TP*CP*CP*AP*GP*CP*G)-3'), DNA (5'-D(P*TP*CP*TP*CP*AP*TP*CP*TP*TP*TP*AP*TP*GP*CP*GP*TP*C)-3'), ... Authors: Bravo, J.P.K, Hibshman, G.N, Taylor, D.W. Deposit date: 2023-09-08 Release date: 2024-05-01 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9. Nat Commun, 15, 2024
8WAZ	De novo transcribing complex 16 (TC16), the early elongation complex with Pol II positioned 16nt downstream of TSS Descriptor: Alpha-amanitin, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... Authors: Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. Deposit date: 2023-09-08 Release date: 2023-12-06 Last modified: 2024-01-03 Method: ELECTRON MICROSCOPY (2.76 Å) Cite: Structural visualization of transcription initiation in action. Science, 382, 2023
8WB0	De novo transcribing complex 17 (TC17), the early elongation complex with Pol II positioned 17nt downstream of TSS Descriptor: Alpha-amanitin, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... Authors: Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. Deposit date: 2023-09-08 Release date: 2023-12-06 Last modified: 2024-01-03 Method: ELECTRON MICROSCOPY (2.94 Å) Cite: Structural visualization of transcription initiation in action. Science, 382, 2023
8WAY	De novo transcribing complex 15 (TC15), the early elongation complex with Pol II positioned 15nt downstream of TSS Descriptor: Alpha-amanitin, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... Authors: Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. Deposit date: 2023-09-08 Release date: 2023-12-06 Last modified: 2024-01-03 Method: ELECTRON MICROSCOPY (2.85 Å) Cite: Structural visualization of transcription initiation in action. Science, 382, 2023
8WAT	De novo transcribing complex 10 (TC10), the early elongation complex with Pol II positioned 10nt downstream of TSS Descriptor: Alpha-amanitin, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... Authors: Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. Deposit date: 2023-09-08 Release date: 2023-12-06 Last modified: 2024-01-03 Method: ELECTRON MICROSCOPY (2.82 Å) Cite: Structural visualization of transcription initiation in action. Science, 382, 2023
8WAV	De novo transcribing complex 12 (TC12), the early elongation complex with Pol II positioned 12nt downstream of TSS Descriptor: Alpha-amanitin, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... Authors: Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. Deposit date: 2023-09-08 Release date: 2023-12-06 Last modified: 2024-01-03 Method: ELECTRON MICROSCOPY (2.72 Å) Cite: Structural visualization of transcription initiation in action. Science, 382, 2023
8WAS	Structure of transcribing complex 9 (TC9), the initially transcribing complex with Pol II positioned 9nt downstream of TSS. Descriptor: Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... Authors: Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. Deposit date: 2023-09-08 Release date: 2023-12-06 Last modified: 2024-01-03 Method: ELECTRON MICROSCOPY (6.13 Å) Cite: Structural visualization of transcription initiation in action. Science, 382, 2023
8WAU	De novo transcribing complex 11 (TC11), the early elongation complex with Pol II positioned 11nt downstream of TSS Descriptor: Alpha-amanitin, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... Authors: Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. Deposit date: 2023-09-08 Release date: 2023-12-06 Last modified: 2024-01-03 Method: ELECTRON MICROSCOPY (2.78 Å) Cite: Structural visualization of transcription initiation in action. Science, 382, 2023
8WAQ	Structure of transcribing complex 7 (TC7), the initially transcribing complex with Pol II positioned 7nt downstream of TSS. Descriptor: Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... Authors: Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. Deposit date: 2023-09-08 Release date: 2023-12-06 Last modified: 2024-01-03 Method: ELECTRON MICROSCOPY (6.29 Å) Cite: Structural visualization of transcription initiation in action. Science, 382, 2023
8WAP	Structure of transcribing complex 6 (TC6), the initially transcribing complex with Pol II positioned 6nt downstream of TSS. Descriptor: Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... Authors: Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. Deposit date: 2023-09-08 Release date: 2023-12-06 Last modified: 2024-01-03 Method: ELECTRON MICROSCOPY (5.85 Å) Cite: Structural visualization of transcription initiation in action. Science, 382, 2023
8WAR	Structure of transcribing complex 8 (TC8), the initially transcribing complex with Pol II positioned 8nt downstream of TSS. Descriptor: Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... Authors: Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. Deposit date: 2023-09-08 Release date: 2023-12-06 Last modified: 2024-01-03 Method: ELECTRON MICROSCOPY (7.2 Å) Cite: Structural visualization of transcription initiation in action. Science, 382, 2023
8WAX	De novo transcribing complex 14 (TC14), the early elongation complex with Pol II positioned 14nt downstream of TSS Descriptor: Alpha-amanitin, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... Authors: Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. Deposit date: 2023-09-08 Release date: 2023-12-06 Last modified: 2024-01-03 Method: ELECTRON MICROSCOPY (2.75 Å) Cite: Structural visualization of transcription initiation in action. Science, 382, 2023
8WAW	De novo transcribing complex 13 (TC13), the early elongation complex with Pol II positioned 13nt downstream of TSS Descriptor: Alpha-amanitin, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... Authors: Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. Deposit date: 2023-09-08 Release date: 2023-12-06 Last modified: 2024-01-03 Method: ELECTRON MICROSCOPY (3.02 Å) Cite: Structural visualization of transcription initiation in action. Science, 382, 2023
8QHP	Cysteine tRNA ligase homodimer Descriptor: Cysteine--tRNA ligase, ZINC ION Authors: Pacesa, M, Correia, B.E, Levy, E.D. Deposit date: 2023-09-08 Release date: 2023-11-29 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: An atlas of protein homo-oligomerization across domains of life. Cell, 187, 2024
8U3M	The FARFAR-MD-NMR ensemble of an HIV-1 TAR excited state Descriptor: The excited state of HIV-1 transactivation response element (31-MER) Authors: Geng, A, Ganser, L, Roy, R, Shi, H, Pratihar, S, Case, D.A, Al-Hashimi, H.M. Deposit date: 2023-09-07 Release date: 2023-10-04 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: An RNA excited conformational state at atomic resolution. Nat Commun, 14, 2023
8WAL	Structure of transcribing complex 3 (TC3), the initially transcribing complex with Pol II positioned 3nt downstream of TSS. Descriptor: Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... Authors: Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. Deposit date: 2023-09-07 Release date: 2023-12-06 Last modified: 2024-01-03 Method: ELECTRON MICROSCOPY (8.52 Å) Cite: Structural visualization of transcription initiation in action. Science, 382, 2023
8WAK	Structure of transcribing complex 2 (TC2), the initially transcribing complex with Pol II positioned 2nt downstream of TSS. Descriptor: Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... Authors: Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. Deposit date: 2023-09-07 Release date: 2023-12-06 Last modified: 2024-01-03 Method: ELECTRON MICROSCOPY (5.47 Å) Cite: Structural visualization of transcription initiation in action. Science, 382, 2023

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