PDB: 84 resultsInfo pagesStatus searchChemie searchBIRD

---

8WQC	cryo-EM structure of neddylated CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CDK5R1 Descriptor: Cullin-2, E3 ubiquitin-protein ligase RBX1, N-terminally processed, ... Authors: Chen, X, Zhang, K, Xu, C. Deposit date: 2023-10-11 Release date: 2024-04-03 Method: ELECTRON MICROSCOPY (3.54 Å) Cite: cryo-EM structure of neddylated CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CDK5R1 To Be Published
8WQB	Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 2) Descriptor: Coiled-coil domain-containing protein 89, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... Authors: Chen, X, Zhang, K, Xu, C. Deposit date: 2023-10-11 Release date: 2024-04-03 Method: ELECTRON MICROSCOPY (3.37 Å) Cite: Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 2) To Be Published
8WQF	cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CUX1 (conformation 2) Descriptor: Cullin-2, E3 ubiquitin-protein ligase RBX1, N-terminally processed, ... Authors: Chen, X, Zhang, K, Xu, C. Deposit date: 2023-10-11 Release date: 2024-04-03 Method: ELECTRON MICROSCOPY (3.27 Å) Cite: cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CUX1 (conformation 2) To Be Published
8WQH	cryo-EM structure of neddylated CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 2) Descriptor: Coiled-coil domain-containing protein 89, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... Authors: Chen, X, Zhang, K, Xu, C. Deposit date: 2023-10-11 Release date: 2024-04-03 Method: ELECTRON MICROSCOPY (3.44 Å) Cite: cryo-EM structure of neddylated CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 2) To Be Published
8WQG	cryo-EM structure of neddylated CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 1) Descriptor: Cullin-2, E3 ubiquitin-protein ligase RBX1, N-terminally processed, ... Authors: Chen, X, Zhang, K, Xu, C. Deposit date: 2023-10-11 Release date: 2024-04-03 Method: ELECTRON MICROSCOPY (4.09 Å) Cite: cryo-EM structure of neddylated CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 1) To Be Published
8QU8	PROTAC-mediated complex of KRAS with VHL/Elongin-B/Elongin-C/Cullin-2/Rbx1 Descriptor: (2S,4R)-1-[(2S)-2-[4-[4-[(3S)-4-[4-[5-[(4S)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5H-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]pyrimidin-2-yl]-3-methyl-1,4-diazepan-1-yl]butoxy]-1,2,3-triazol-1-yl]-3-methyl-butanoyl]-N-[(1R)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-2-oxidanyl-ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... Authors: Fischer, G, Peter, D, Arce-Solano, S. Deposit date: 2023-10-14 Release date: 2023-12-06 Last modified: 2024-01-24 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Targeting cancer with small molecule pan-KRAS degraders Biorxiv, 2023
8R5H	Ubiquitin ligation to neosubstrate by a cullin-RING E3 ligase & Cdc34: NEDD8-CUL2-RBX1-ELOB/C-VHL-MZ1 with trapped UBE2R2~donor UB-BRD4 BD2 Descriptor: (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-2,3-dihydro-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, 5-azanylpentan-2-one, Bromodomain-containing protein 4, ... Authors: Liwocha, J, Prabu, J.R, Kleiger, G, Schulman, B.A. Deposit date: 2023-11-16 Release date: 2024-02-21 Last modified: 2024-04-17 Method: ELECTRON MICROSCOPY (3.44 Å) Cite: Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting. Mol.Cell, 84, 2024
8RWZ	Open non-crosslinked structure Brd4BD2-MZ1-(NEDD8)-CRL2VHL Descriptor: (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-2,3-dihydro-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Bromodomain-containing protein 4, Cullin-2, ... Authors: Ciulli, A, Crowe, C, Nakacone, M.A. Deposit date: 2024-02-05 Release date: 2024-03-06 Method: ELECTRON MICROSCOPY (4 Å) Cite: Open non-crosslinked structure Brd4BD2-MZ1-(NEDD8)-CRL2VHL To Be Published
8RX0	(NEDD8)-CRL2VHL-MZ1-Brd4BD2-Ub(G76S, K48C)-UBE2R1(C93K, S138C, C191S, C223S)-Ub Descriptor: (2~{S},4~{R})-1-[(2~{S})-2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{N}-[[4-(4-methyl-2,3-dihydro-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Cullin-2, Elongin-B, ... Authors: Crowe, C, Nakasone, M.A. Deposit date: 2024-02-05 Release date: 2024-03-06 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: (NEDD8)-CRL2VHL-MZ1-Brd4BD2-Ub(G76S, K48C)-UBE2R1(C93K, S138C, C191S, C223S)-Ub To Be Published

<1234