2AHY
 
 | | Na+ complex of the NaK Channel | | Descriptor: | CALCIUM ION, Potassium channel protein, SODIUM ION | | Authors: | Shi, N, Ye, S, Alam, A, Chen, L, Jiang, Y. | | Deposit date: | 2005-07-28 | | Release date: | 2006-02-07 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Atomic structure of a Na+- and K+-conducting channel.
Nature, 440, 2006
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2AHZ
 | | K+ complex of the NaK Channel | | Descriptor: | CALCIUM ION, POTASSIUM ION, Potassium channel protein | | Authors: | Shi, N, Ye, S, Alam, A, Chen, L, Jiang, Y. | | Deposit date: | 2005-07-28 | | Release date: | 2006-02-07 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Atomic structure of a Na+- and K+-conducting channel.
Nature, 440, 2006
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2ATK
 | | Structure of a mutant KcsA K+ channel | | Descriptor: | ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, NONAN-1-OL, ... | | Authors: | Cordero-Morales, J.F, Cuello, L.G, Zhao, Y, Jogini, V, Chakrapani, S, Roux, B, Perozo, E. | | Deposit date: | 2005-08-25 | | Release date: | 2006-03-07 | | Last modified: | 2021-11-10 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Molecular determinants of gating at the potassium-channel selectivity filter.
Nat.Struct.Mol.Biol., 13, 2006
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2DWD
 | | crystal structure of KcsA-FAB-TBA complex in Tl+ | | Descriptor: | (2S)-3-HYDROXY-2-(NONANOYLOXY)PROPYL LAURATE, ANTIBODY FAB HEAVY CHAIN, ANTIBODY FAB LIGHT CHAIN, ... | | Authors: | Yohannan, S, Zhou, Y. | | Deposit date: | 2006-08-10 | | Release date: | 2007-02-20 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystallographic Study of the Tetrabutylammonium Block to the KcsA K(+) Channel
J.Mol.Biol., 366, 2007
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2DWE
 | | Crystal structure of KcsA-FAB-TBA complex in Rb+ | | Descriptor: | (2S)-3-HYDROXY-2-(NONANOYLOXY)PROPYL LAURATE, ANTIBODY FAB HEAVY CHAIN, ANTIBODY FAB LIGHT CHAIN, ... | | Authors: | Yohannan, S, Zhou, Y. | | Deposit date: | 2006-08-10 | | Release date: | 2007-02-20 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystallographic Study of the Tetrabutylammonium Block to the KcsA K(+) Channel
J.Mol.Biol., 366, 2007
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4UUJ
 | | POTASSIUM CHANNEL KCSA-FAB WITH TETRAHEXYLAMMONIUM | | Descriptor: | ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, COBALT (II) ION, ... | | Authors: | Lenaeus, M.J, Burdette, D, Wagner, T, Focia, P.J, Gross, A. | | Deposit date: | 2014-07-29 | | Release date: | 2014-08-27 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structures of Kcsa in Complex with Symmetrical Quaternary Ammonium Compounds Reveal a Hydrophobic Binding Site.
Biochemistry, 53, 2014
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4WFH
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4WFE
 | | Human TRAAK K+ channel in a K+ bound conductive conformation | | Descriptor: | ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ... | | Authors: | Brohawn, S.G, MacKinnon, R. | | Deposit date: | 2014-09-15 | | Release date: | 2014-12-03 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014
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4WFG
 | | Human TRAAK K+ channel in a Tl+ bound conductive conformation | | Descriptor: | ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ... | | Authors: | Brohawn, S.G, MacKinnon, R. | | Deposit date: | 2014-09-15 | | Release date: | 2014-12-03 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Nature, 516, 2014
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4WFF
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7MHX
 | | KcsA E71V closed gate with Ba2+ | | Descriptor: | BARIUM ION, DIACYL GLYCEROL, Fab heavy chain, ... | | Authors: | Rohaim, A, Li, J, Weingarth, M, Roux, B. | | Deposit date: | 2021-04-15 | | Release date: | 2022-03-23 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | A distinct mechanism of C-type inactivation in the Kv-like KcsA mutant E71V.
Nat Commun, 13, 2022
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7MUB
 | | KcsA Open gate E71V mutant in Potassium | | Descriptor: | Fab heavy chain, Fab light chain, POTASSIUM ION, ... | | Authors: | Rohaim, A, Li, J, Weingarth, M, Roux, B. | | Deposit date: | 2021-05-14 | | Release date: | 2022-03-23 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | A distinct mechanism of C-type inactivation in the Kv-like KcsA mutant E71V.
Nat Commun, 13, 2022
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7MHR
 | | KcsA E71V closed gate with K+ | | Descriptor: | Fab heavy chain, Fab light chain, POTASSIUM ION, ... | | Authors: | Rohaim, A, Li, J, Weingarth, M, Roux, B. | | Deposit date: | 2021-04-15 | | Release date: | 2022-03-23 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.77 Å) | | Cite: | A distinct mechanism of C-type inactivation in the Kv-like KcsA mutant E71V.
Nat Commun, 13, 2022
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7MK6
 | | KcsA open gate E71V mutant with sodium | | Descriptor: | Fab heavy chain, Fab light chain, pH-gated potassium channel KcsA | | Authors: | Rohaim, A, Li, J, Weingarth, M, Roux, B. | | Deposit date: | 2021-04-21 | | Release date: | 2022-03-23 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | A distinct mechanism of C-type inactivation in the Kv-like KcsA mutant E71V.
Nat Commun, 13, 2022
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7MJT
 | | KcsA open gate E71V mutant with Barium | | Descriptor: | BARIUM ION, Fab heavy chain, Fab light chain, ... | | Authors: | Rohaim, A, Li, J, Weingarth, M, Roux, B. | | Deposit date: | 2021-04-20 | | Release date: | 2022-03-23 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | A distinct mechanism of C-type inactivation in the Kv-like KcsA mutant E71V.
Nat Commun, 13, 2022
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4XDK
 | | Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with norfluoxetine | | Descriptor: | (3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, (3S)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | | Authors: | Pike, A.C.W, Dong, Y.Y, Mackenzie, A, Mukhopadhyay, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Carpenter, E.P, Structural Genomics Consortium (SGC) | | Deposit date: | 2014-12-19 | | Release date: | 2015-03-18 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Science, 347, 2015
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4XDL
 | | Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with a brominated fluoxetine derivative. | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[2-bromanyl-4-(trifluoromethyl)phenoxy]-N-methyl-3-phenyl-propan-1-amine, CADMIUM ION, ... | | Authors: | Mackenzie, A, Pike, A.C.W, Dong, Y.Y, Mukhopadhyay, S, Ruda, G.F, Brennan, P.E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Carpenter, E.P, Structural Genomics Consortium (SGC) | | Deposit date: | 2014-12-19 | | Release date: | 2015-03-18 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Science, 347, 2015
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4XDJ
 | | Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in an alternate conformation (FORM 2) | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, POTASSIUM CHANNEL SUBFAMILY K MEMBER 10, POTASSIUM ION, ... | | Authors: | Pike, A.C.W, Dong, Y.Y, Mackenzie, A, Mukhopadhyay, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Carpenter, E.P, Structural Genomics Consortium (SGC) | | Deposit date: | 2014-12-19 | | Release date: | 2015-03-18 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Science, 347, 2015
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7MDJ
 | | The structure of KcsA in complex with a synthetic Fab | | Descriptor: | Fab heavy chain, Fab light chain, POTASSIUM ION, ... | | Authors: | Rohaim, A, Slezak, T, Blackowicz, L, Kossiakoff, A, Roux, B. | | Deposit date: | 2021-04-05 | | Release date: | 2022-02-16 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Engineering of a synthetic antibody fragment for structural and functional studies of K+ channels.
J.Gen.Physiol., 154, 2022
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4ZBM
 | | Crystal structure of Drosophila cyclic nucleotide gated channel pore mimicking NaK mutant | | Descriptor: | BARIUM ION, POTASSIUM ION, Potassium channel protein | | Authors: | Lam, Y, Zeng, W, Derebe, M.G, Jiang, Y. | | Deposit date: | 2015-04-14 | | Release date: | 2015-07-29 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural implications of weak Ca2+ block in Drosophila cyclic nucleotide-gated channels.
J.Gen.Physiol., 146, 2015
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3IFX
 | | Crystal structure of the Spin-labeled KcsA mutant V48R1 | | Descriptor: | POTASSIUM ION, S-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate, TETRABUTYLAMMONIUM ION, ... | | Authors: | Cieslak, J.A, Focia, P.J, Gross, A. | | Deposit date: | 2009-07-26 | | Release date: | 2010-02-09 | | Last modified: | 2023-09-06 | | Method: | EPR (3.56 Å), X-RAY DIFFRACTION | | Cite: | Electron Spin-Echo Envelope Modulation (ESEEM) Reveals Water and Phosphate Interactions with the KcsA Potassium Channel
Biochemistry, 49, 2010
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5CBH
 | | Structural and Functional Characterization of a Calcium-activated Cation channel from Tsukamurella Paurometabola | | Descriptor: | CALCIUM ION, Ion transport 2 domain protein | | Authors: | Dhakshnamoorthy, B, Rohaim, A, Rui, H, Blachowicz, L, Roux, B. | | Deposit date: | 2015-06-30 | | Release date: | 2016-07-20 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.37 Å) | | Cite: | Structural and functional characterization of a calcium-activated cation channel from Tsukamurella paurometabola.
Nat Commun, 7, 2016
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3K03
 | | Crystal Structure of CNG mimicking NaK mutant, NaK-DTPP, K+ complex | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, POTASSIUM ION, Potassium channel protein NaK | | Authors: | Jiang, Y, Derebe, M.G. | | Deposit date: | 2009-09-24 | | Release date: | 2011-01-12 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Tuning the ion selectivity of tetrameric cation channels by changing the number of ion binding sites.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3K04
 | | Crystal Structure of CNG mimicking NaK mutant, NaK-DTPP, Na+ complex | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Potassium channel protein NaK, SODIUM ION | | Authors: | Jiang, Y, Derebe, M.G. | | Deposit date: | 2009-09-24 | | Release date: | 2011-01-12 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.58 Å) | | Cite: | Structural studies of ion permeation and Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore.
Proc.Natl.Acad.Sci.USA, 108, 2011
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4H37
 | | Crystal structure of a voltage-gated K+ channel pore domain in a closed state in lipid membranes | | Descriptor: | Lmo2059 protein, POTASSIUM ION | | Authors: | Santos, J.S, Asmar-Rovira, G.A, Han, G.W, Liu, W, Syeda, R, Cherezov, V, Baker, K.A, Stevens, R.C, Montal, M. | | Deposit date: | 2012-09-13 | | Release date: | 2012-11-07 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.35 Å) | | Cite: | Crystal Structure of a Voltage-gated K+ Channel Pore Module in a Closed State in Lipid Membranes.
J.Biol.Chem., 287, 2012
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